Posted by admin on May 31, 2022 in |
Parkinson’s disease (PD), identified as the second most common neurodegenerative disorder, is a progressive disease that impairs the ability to control voluntary movements mainly. According to the findings of the pathogenesis of PD, lesions in dopaminergic innervation of the basal ganglia cause degeneration of neurons in the substantia nigra and thus leads to loss of striatal dopamine level. Hence, enhancement of dopaminergic transmission restores partial motor functions. In the current review, the possible in-vivo animal models have been described in detail, which mostly resembles the Parkinsonian state in humans and has helped research involving pathogenesis, treatment, and evaluating drugs having Anti-Parkinson activity. This study aims to set down all the possible models to screen agents that have a therapeutic or symptomatic role in treating Parkinson’s disease. Every model has its advantage and disadvantage, which must be carefully considered when choosing the model to be...
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Posted by admin on May 31, 2022 in |
In any nation’s public health care system, plants play an essential role in therapeutic treatment. The plant Thevetia peruviana is an evergreen ornamental dicotyledonous shrub belonging to the family Apocynaceae. Thevetia peruviana is widely distributed in Central and South America and Asian countries, especially in India and Srilanka. Alkaloids, flavonoids, steroids, terpenoids, tannins, saponins, cardiac glycosides, and other secondary metabolites are found in Thevetia peruviana. All parts of these plants are toxic and contain a variety of cardiac glycosides, including neriifolin, thevetin A, thevetin B, and oleandrin. The leaves of the plant are used as a cardiotonic and diuretic and are also reported to possess medicinal value in traditional systems of medicine. Several studies reported pharmacological activity in various plant parts, including seeds, flowers, bark, fruits and leaves. The purpose of this review is to provide the complete data, including morphology, cultivation and propagation, distribution, phytochemistry, traditional uses & pharmacological...
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Posted by admin on May 31, 2022 in |
Microsphere drug delivery is a novel drug delivery approach for sustaining and controlling the rate and release of active pharmaceutical ingredients. Microspheres are the choice of drug delivery for delivering the drug at a specific site to release the encapsulated drug to treat various diseases. Microspheres drug delivery is an attractive dosage form in terms of its flexibility and sustaining the release as compared to other sustained and controlled formulations. Most of the antihyperlipidemic drugs come under BCS class-II, which leads to poor solubility but higher permeability, the oral bioavailability of statins categories drug possess less bioavailability due to the poor solubility; hence microspheres are the best candidate for delivering antihyperlipidemic drugs to the systemic circulation and improving the systemic bioavailability of drug for a longer period with lesser adverse effects. Therefore microspheres can be used in various medical departments like oncology, gynecology, radiology, pulmonary, cardiology, diabetes, vaccine therapy, etc. this review article focuses on recent different methods of preparation. The microspheres formulated can be later evaluated and characterized...
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Posted by admin on May 31, 2022 in |
The plant Salvia hispanica belongs to the family Lamiaceae, a highly valued medicinally important seed, commonly known as chia seeds. About 75% of the fats in chia seeds consist of omega-3 alpha-linolenic acid (ALA), while about 20% consist of omega-6 fatty acid. Omega-3s play an important role in sharpening memory and improving mood. Chia seeds also contain polyunsaturated fatty acids, dietary fiber, proteins, vitamins (A, C, E, niacin, thiamine), and minerals. Besides this, the seeds are an excellent source of polyphenols and antioxidants, such as caffeic acid, rosmarinic acid, myricetin, quercetin, and others. These antioxidants exhibit the capacity to scavenge free radicals. Chia’s health benefits as a dietary supplement and efforts are underway to promote it as ‘functional food’ owing to the presence of α-linolenic acid, an essential precursor fatty acid of physiologically significant polyunsaturated fatty acids. Chia seeds also possess various pharmacological activities like anti-inflammatory, antihypertensive, anti-diabetic, anti-cancer and it also reduces the risk factors of heart disease. It is commonly used for weight loss. And it also...
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Posted by admin on May 31, 2022 in |
Anorectal disorders are often perceived in surgery practice and often reside with pain with shifting vigour. Endeavour has been made to lessen pain and avoid ligature. Minuscule hospital stay with early return to work is the main aim of developing newer techniques in the management of anorectal diseases. Diverse modalities with the main tensity on surgical interceding for managing more common anorectal disorders are...
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