Posted by admin on Jan 31, 2022 in |
Drugs have been controlled by the nasal route for remedial & therapeutic use since ancient times. Enthusiasm & importance for the basic impacts of drugs directed via the nasal route has developed to last decades. Intra-nasal drug organization provides an attractive substitute for achieving the important beneficial impacts of drugs virtually similar to the parenteral route, that may be improperly engineered on occasion or through the oral organization, that may contribute to inadequately low bioavailability of drugs. Along these lines, it is crucial to identify the potential & impediments of various nasal drug conveyance frameworks. In this way, the object of this paper is to study the different forms of pharmaceutical dosage that may be utilized in the vicinity or in a basic drug organization. It is obviously anticipated that this study would help to understand & advance expand appropriate intra-nasal strategies to meet specific restorative...
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Posted by admin on Jan 31, 2022 in |
Perilla frutescens (Linn.) is an annual herbal medicinal, aromatic, vitamins-rich food and ornamental plant that belongs to the mint family, Lamiaceae. It is distributed throughout India, extending to China, Japan, Korea, Taiwan, Vietnam, and other Asian countries. Perilla frutescens seeds, leaves and stems contain fixed oil which is useful edible oil. It is an alternative source of polyunsaturated fatty acids (linolenic acid (54%-64%), i.e., omega-3-fatty acids), phenolic compounds (rosmarinic acids, luteolin, chrysoleriol, quercetin, catechin, protocatechuic acid, and apigenin), natural antioxidants, vitamins and minerals. Recent advances prove that compounds purified from Perilla frutescens have been proven to be biologically active against several major diseases to treat depression-related diseases, anxiety, asthma, chest stuffiness, vomiting, coughs, colds, flu, phlegm, tumors, allergies, intoxication, fever, headache, stuffy nose, constipation, abdominal pain, and indigestion. It also acts as an analgesic, anti-abortive agent, sedative such as an antioxidant, antimicrobial, anti-allergic, antidepressant, anti-inflammatory, anticancer and neuroprotective activities. This present review deals with the update of biological activities of isolated bioactive chemical constituents of Perilla frutescens and explores...
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Posted by admin on Jan 31, 2022 in |
Pollution and overgrowing populations cause many problems such as environmental degradation, climate change, disease, etc. Among all the problems, the disease is an important factor that may affect the normal day-to-day activities of human beings, and it may be fatal sometime. Hence many researchers, government and private sectors are involved in the process of formulating new drugs to the existing diseases. Western medicine is the widely accepted way of medical practice which is adopted by many countries. But unfortunately, sometimes Western medicine is not applicable for certain people due to their allergic nature, cost and unavailability, etc. Hence peoples search for alternate medicine to cure their ailments. Siddha System of Medicine (SSM) is one of the widely accepted ways of alternate medicine practiced in India’s southern region. This Siddha medicine is widely used to treat various dangerous diseases like cancer, liver disease, viral diseases, etc. Liver disease is common in developing countries like India. The Thiratchai kudineer is a polyherbal formulation used to treat various liver diseases. Thus, this...
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Posted by admin on Jan 31, 2022 in |
Zolmitriptan is a selective serotonin receptor agonist of 1B and 1D receptors belonging to the triptan class. Zolmitriptan binds to the serotonin (5-HT) 1B receptors, receptor binding leads to inhibition of nociceptive transmission, constriction of cranial vessels, and reduction of vessel pulsation, thereby providing relief of migraine headaches, as Zolmitriptan holds great importance in migraine headaches, it is necessary to compile the various analytical methods that have been reported in the literature for its analysis in pharmaceuticals or bulk products and in bioanalysis. Analytical techniques are used for pharmaceutical analysis and therapeutic drug monitoring to study bioavailability and bioequivalence. Most of the analytical methods reported for its determination are the ones that utilize HPLC and other hyphenated techniques like LC-MS, UPLC-MS, LC-MS/MS. Therefore, the present review provides a summary of the HPLC-based methods used in the determination and quantification of Zolmitriptan in different matrices since the time of its...
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Posted by admin on Jan 31, 2022 in |
HIV is a pandemic disease that is rapidly spreading across the world. The current review’s objective is to present how comprehensive various advanced anti-HIV drug delivery systems are. The use of a new drug delivery system helps in overcoming the challenges of dosage form growth, such as drug instability, insolubility, and restricted entrapment. Several delivery routes for ARV therapy have been identified, including trans dermal, mucosal (vaginal, rectal, buccal, etc.) and lymphatic delivery, utilizing novel systems such as nanoparticles, vesicular systems (liposomes, niosomes, ethosomes, emulsomes), micellar assemblies and so on. This review examines the potential of novel drug delivery systems for the prevention, treatment of retroviral infections, approaches and applications of novel drug delivery systems for Anti-HIV...
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