Posted by admin on Dec 31, 2021 in |
Characteristics like dementia, behavioural and cognitive dysfunction, and memory decline may characterize Alzheimer’s disease (AD). A deterioration of short-term memory, inability to acknowledge new information, mood swings, difficulty recognizing words, forgetting names, and losing things are demonstrated by early disease. Popular emotional characteristics displayed by patients with AD are anger, aggression, and irritability. Today’s world attempts to treat various ailments have increased with medical advancements. There is still considerable research into medications capable of preventing or at least effectively altering the trajectory of AD, referred to as ‘disease-modifying medicines. Laboratory animals are helping to test new ways of treating illness. For the goal of developing therapeutics or disease-modifying agents, a vast array of experimental models were developed to simulate the human context of the illness. In animal studies, AD caused by chemical compounds may be helpful in deeper understanding the mechanism of disease and AD treatment. The anticholinergic drug Scopolamine induces amnesia in rodents. This analysis examines the various animal models frequently used to research the effect of novel...
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Posted by admin on Dec 31, 2021 in |
Tissues can be preserved for centuries under the conditions of extremely cold temperatures along with the neurological functions of the human brain. It is possible with the process of vitrification; here the cells of the brain are cooled to the cryogenic temperature without the formation of ice. Damage caused due to this process is theoretically reversible as like before, but practically, rejuvenation is possible only by the foreseeable technology which is specific. Injury caused to brain because of low or stopping of blood flow which is as a result of complex series of process which takes more than 6min of time to complete the limit of resuscitation technology. Damage of blood vessels occurs first then the brain tissues if the process of rejuvenation occurs for more than 6 min. For permanent death of neurons, many hours are required. The process of cryopreservation provides a chance for resuscitation by having an opportunity between legal death and permanent loss of life in both humans and animals. At appropriate conditions, the time...
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Posted by admin on Dec 31, 2021 in |
SARS-CoV-2 viral cause infection called COVID-19 was initially reported in China has resulted in a pandemic because it has spread in over 210 countries. This review summarized pathophysiology, clinical features, diagnosis, and COVID 19. The spread of SARS-CoV-2 viral infections is a matter of concern because of a mutant variant of virus. The COVID-19 infection is having 14 days incubation period. Fever, sore throat, cough, severe headache, breathlessness, myalgia and weakness are common symptoms observed in patients with COVID-19. Steps of replication of SARS-CoV-2 virus are attachment, penetration, uncoating, replication, assembly and release. Patients’ screening tests are complete blood count, C-reactive protein (CRP) and erythrocyte, sedimentation rate (ESR), D-dimer, serum ferritin, and others. The reverse transcription-polymerase chain reaction (RT-PCR) is the important diagnostic test of molecular genetic assays for detecting viral RNA. In-Patient of COVID 19 CT scan shows ground-glass opacities with or without consolidations in lung regions. In CT scan, standardized assessment scheme is CORAD classification and assessment of lung involvement can be done CT severity score index....
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Posted by admin on Dec 31, 2021 in |
Medical Case taking process in any field of medicine science is considered to be a significant stage for the treatment management of various diseases. Cardio Vascular diseases (CVD) are one of the life-threatening diseases across the globe, and its prognosis entirely depends on the right intuition of the clinicians; cases may account for 31% of deaths worldwide, based on a recent study. Big Data Management and Machine Learning Algorithms have reached paramount Computational Technological advancement over the last decade and capable of drive applications in diverse domains which can assist in the process of selecting proper medicines. The case-taking approach and selection of drugs were significantly correlated, and the skill of the physicians plays a very important role in the entire procedure blended with proper use of Smart Technology, Artificial Intelligence, and Cloud storage of huge volume of patient’s physiological, clinical and pathological data. In this paper, we have made an attempt to build a digital system driven by smart technology to cater to this equation and explore the...
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Posted by admin on Dec 31, 2021 in |
Discovery of the drug molecule which has therapeutic values is the backbone of drug development. Pharmaceuticals have an important role in the prevention and treatment of diseases in humans and animals. However, gradual change in the process of drug synthesis from drug development to bulk production is a common complication in the drug development process. This change may result in the formation of impurities. Moreover, impurities can also be formed during transport and storage. The presence of more than the prescribed limit of impurities in the drugs may influence the purpose of the pharmaceuticals. Therefore, the evaluation of pharmaceutical drugs for the identification and quantification of impurities at various stages is essential. Several chemical and instrumental methods are used to assess the impurities. For this purpose, analytical instrumentations and methods play a crucial role. The current review highlights the development of impurities at various stages of drug development and pharmaceutical manufacturing. Moreover, this review put light on the recent advancement in the analysis of...
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