Posted by admin on Jun 30, 2021 in |
World Health Organization (WHO) designated the COVID-19 or more commonly called Coronavirus disease, a “public health emergency of international concern” on January 30, 2020, and declared it a pandemic on March 11, 2020, which threatens human wellbeing around the world. With no proven pharmacological treatment, therapy (such as plasma, bacteriophage, virophage) drug approved by Food and Drug Administration (FDA) against COVID-19 and the frequent transmission of infection resulting in progression of infected person; made the situation more critical. The critical pandemic situation created by COVID-19 realized that nutrition becomes a priority to boost immune function as what we eat can have severe health impacts and medical consequences. The present assessment focused on enhancing awareness among people to maintain a healthy lifestyle through balanced food, nutrition, and eating habits, and AYUSH recommendations to overcome inevitably caused distress due to pandemic...
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Posted by admin on Jun 30, 2021 in |
Nanocochleate is a novel lipid-based drug delivery system in which the liposomal vesicles are converted into nanocochleate by the addition of Calcium divalent cation. This technology involves encochleation of the drug for overcoming problems such as poor solubility, poor permeability, and poor oral bioavailability. This novel lipid-based formulation approach is applicable for the category of drugs like BCS class III drugs, BCS class IV drugs. Applications of this technology can also be extended to macromolecules as well as small molecule drugs that are lipophilic with poor oral bioavailability. It is appropriate for oral as well as systemic administration of biologically active molecules, including drugs, genes, proteins, peptides, and vaccine antigens. This article covers multiple aspects of Nanocochleate drug delivery system, such as its definition, composition, method of preparation, and mechanism of permeation. The article also elaborates on various advantages, disadvantages, and applications of Nanocochleate drug delivery system. The article highlights the potential of this novel system for oral as well as systemic delivery of chemical and biological drug...
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Posted by admin on Jun 30, 2021 in |
Considering the increasing trend of the cancer rate of numerous organs, efficient treatments are highly required to restrain human melanomas. Cancer is among the most prevalent illnesses ascertained in developed countries, estimating more than 1.50 million fresh instances in the US alone in 2017. Though, approximately most of the chemotherapeutic drugs presently on the market cause major adverse effects like immunodeficiency, fatigue, alopecia, anaemia, peripheral neuropathy, neurological problems, and fertility issues, to name a few of them. Polysaccharides have developed as potential chemical entities revealing effective immunomodulatory activity within a variety of cell lines and can be developed as alternatives to existing cancer chemotherapeutic agents, possessing minimal toxic side-effects. Polysaccharides isolated from plants, microorganisms, fungi, and marine sources have been reported. They function via TLR modulation, activation and maturation of Dendritic cells, Cytokines signalling pathway, macrophage activation, and miscellaneous pathways like PI3K, MAPK activation, the complement supplement system. This review concentrates on the polysaccharides explored over the past five to seven years as an adjuvant therapeutic agent, their suggested...
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Posted by admin on Jun 30, 2021 in |
COVID-19 has been proved to create a pandemic over the world within a few years. All scientists and health workers are trying to develop an effective treatment with collaboration. Various strategies such as antiviral, antibacterial, and antimalarial drugs have been employed to treat COVID- 19, but they were found to relieve the symptoms only. The formation of various variants of the virus in various global parts made the treatment of COVID-19 more difficult. Developing an effective vaccine is the main goal of clinicians and scientists, which is under clinical trials, and some vaccines which have been approved for the treatment such as COVAXIN, COVISHIELD, ASTRA Zenaca, and SPUTNIK V vaccines are being used to develop antibodies against COVID-19, but due to spread of variants of virus these vaccines are not supposed to be 100 percent protective against the virus. With the help of nanotechnology, the treatment of SARS- CoV-2 can be made efficient due to its direct target on viral cells and modifying its genetic material functionings. In this...
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Posted by admin on Jun 30, 2021 in |
The medicinal plant Ricinus communis is one of the effective plants which offer a solution to several kinds of diseases. Owing to this, the present research aims to review the medicinal properties of one of such common herbal plants, Ricinus communis, its possible role as herbal medicine, and assessment for pharma-covigilance. Related research articles were collected from Google Scholar, Pub Med, Science direct, Scientific information Database, and Scopus. For the present study purpose, using the term Ricinus communis, the castor bean, and castor oil plant in the title of all articles published to 2021 were observed. Phytochemical constituents of R. communis like saponins, flavonoids, alkaloids, steroids, and glucosides. Leaves of the plant have shown the presence of major phenolic compounds. Whereas roots test has presented the Indole-3-acetic. The findings reflect that the plant contains high medicinal benefits, which offer a solution for several kinds of diseases like cancer, diabetes, ulcer and anthelmintic, etc. Also, the plant is anti-inflammatory property of the plant facilitates therapeutic use. Therefore, all parts of...
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