Posted by admin on Mar 31, 2021 in |
Herbal Medicinal Products are gaining acceptance among people across the world due to rising awareness of lifestyle diseases and improper food habits. During the latter part of the twentieth century, increasing interest in self-care resulted in enormous growth in the popularity of traditional healing modalities, including the use of Herbal remedies. Side effects caused by the use of modern medicines are driving consumers towards herbal medicines and their supplements and this is driving the growth of Herbal Medicines across the world. Herbal Medicines, when sold commercially, should comply with country-based regulations concerning safety, quality, and efficacy. At present regulations for herbal medicines differ country-wise. Due to this, herbal medicine companies cannot manufacture a standard product for the global market. Hence a concerted effort should be undertaken by global regulatory authorities and agencies like WHO to establish a uniform and harmonized regulation for herbal medicines. In this paper, we highlighted various challenges and constraints in manufacturing as well as the marketing of herbal medicinal products across the...
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Posted by admin on Feb 28, 2021 in |
Curcumin, chemically 1,7-bis (4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione derived from Curcuma longa L. is an active chemical constituent used medicinally worldwide from ancient times. Though Curcumin enjoying the reputation of many pharmacological actions, it has certain setbacks with poor bioavailability. The poor water solubility is said to be the reason for poor bioavailability, rather it is more about drug permeability and diffusion through different membranes. Curcumin as a drug candidate can be studied by considering various principal factors like rate, time, and location of the release of the drug with respect to its efficacy. It was found that the drug distribution is more at the kidney and liver than other organs due to substantial metabolism and elimination of drug at these sites. Due to its uneven, oversensitive, and non-bioavailable nature, additional clinical trials on curcumin are unwarranted. In fact, poor absorption, rapid metabolism, chemical instability, and quick systemic elimination anything could be a reason for poor bioavailability. The best possible solution for this problem is so narrow and lies somewhere around liposomal...
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Posted by admin on Feb 28, 2021 in |
Today, Nanotechnology is widely used for leading new dosage forms. Vesicular drug delivery system is expanding as one of advanced nanotechnology. Delivery of drugs using colloidal particulate carriers and liquid crystalline compact niosomal hybrid such as niosome and proniosomes has peculiar advantages over conventional dosage forms. Proniosomes is a dry formulation using suitable carrier coated with non-ionic surfactant and can be converted into niosome immediately before use by hydration. These vesicles are amphiphilic molecules having capability of entrapping both hydrophilic and hydrophobic drugs. Vesicular systems are lamellar structures composed of amphiphilic molecules surrounded by an aqueous environment. The non-ionic surfactants are preferred in the proniosomes preparation than cationic, anionic, and ampholytic surfactants because they have the ability to increase solubility which helps in increasing solubility and bioavailability of poorly water soluble drugs. The versatile vesicular drug delivery through the transdermal route is advantageous due to the vesicles tendency to attach and adhere to the cell surface and causes increased permeation rate. However, the major pathways for drug permeation in...
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Posted by admin on Feb 28, 2021 in |
Cancer is one of the main reasons of death around the world and the quantity of new incidents keeps on rising. Despite ongoing advances in conclusion and remedial systems, many malignancy-related passes happen, demonstrating the requirement for better treatments and symptomatic methodologies. Mitochondrial morphology is dependent on continuous fusion and fission strategies that are essential for monitoring a normal mitochondrial function. Past years major discoveries have indicated that the characterization of fission and fusion is a little machinery, which is known as the physiological role of mitochondrial dynamics. Mitochondria (MND) and metabolic adjustments have been perceived as critical for growth movement. The numerous components of those organelles square measure in person connected to their morphology. Late confirmation proposes a significant association between mitochondrial (MNDL) construction and ill health, together with neurodegenerative, incendiary ailments and malignancy. Here, we scrutinize present-day movements within the perception of mitochondrial gestures with a special target with its liaison to cancer and therapeutic ways via synthetic and natural bioactive actives. Some notable compounds in the...
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Posted by admin on Feb 28, 2021 in |
The important barrier in transdermal drug delivery (TDD) is the Stratum corneum (SC), the outermost layer of the skin, which acts as an excellent protective physiological barrier. To boost the penetration or permeation of drugs through SC, several tactics have been used including passive and active methods of permeation or both in combination. This unwraps the opportunity to broaden the range of drugs that can be administered through the transdermal route, performed as alternatives to existing products, and overcomes the weaknesses of conventional routes. The Nanostructured Lipid Carriers (NLCs) seem to be excellent candidates over conventional drug delivery systems. NLCs are fastly growing and in increased demand from pharmaceutical research groups globally since the last decade. After development of liposomes and Solid Lipid Nanoparticles (SLN), NLCs were introduced. NLC overcomes the limitations of SLN, like the limited drug loading capacity and drug expulsion during storage. NLCs receive a preferred choice of formulation in the cosmeceutical market and Pharmaceutical market as well. This review is an overview of the different permeation...
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