Posted by admin on Sep 30, 2020 in |
Zoonoses are human diseases caused by animal pathogens or animal diseases that are transmissible to humans. They are caused by all types of pathogenic agents, including bacteria, parasites, fungi, viruses, and prions. Zoonotic diseases can be transmitted to humans by infected saliva, aerosols, contaminated urine or feces, and direct contact with the animal or pathogenic microbes. Furthermore, transmission can also occur through animal vectors (e.g., tick bite, and insects like mosquitoes or flea). The zoonotic microbes continue to evolve and adapt with tremendous acceleration and expansion of global trade, human movement, and population. Control of zoonotic diseases and protection of public health are challenging tasks as the world population is increasing proportionately. Newly emerging viruses such as the Ebola virus, severe acute respiratory syndrome (SARS)-, Middle East respiratory syndrome (MERS)-coronavirus, and the avian influenza virus, H1N1 virus, Nipah virus, Zika Virus, and now Covid-19 are serious threats to public health and have become a global concern. The prevention of these infections depends on improved diagnosis and highly effective therapeutics/...
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Posted by admin on Sep 30, 2020 in |
In the era of recent technology, robotic surgery will be the ruler of the medical world with its attributes, its journey from a mere idea to today’s world’s surgical epitome. Using the methods of telerobotic visualization and controlling systems, this technology works towards improvement in all the fields of medicine and patient care. Robotic surgery dwells on the functionality of the most widely known models of Da Vinci and Zeus. It has benefited the patients by combining with minimally invasive, transoral, and laparoscopic techniques working better in synergism. It has been to date employed in the surgeries in the fields of the eyes, cranium, bone, thyroid, heart, liver, obesity, gastrointestinal, obstetrics as well as carcinomas. Its future potential is bright based on the types of technologies that are being linked with normal robotic surgery. One such endeavour is the microbot, which makes reaching the smallest nooks and corners of the internal physiology of the human body possible as well as more...
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Posted by admin on Sep 30, 2020 in |
Varieties of natural products have been proved as a rich source of phytoconstituents which are reported for a wide range of therapeutic potential. Plumbago zeylanica L. Is one of the herbs which are traditionally used for its therapeutic value. It is reported for several bioactive chemical constituents like naphthoquinones, flavonoids, alkaloids, glycosides, steroids, tri-terpenoids, tannins, fixed oils, fats, proteins, etc. in its chemical composition. Plumbagin is one of the most bioactive compounds of Plumbago zeylanica L., which is reported for a wide range of pharmacological activities such as anti-cancer, anti-diabetic, anti-malarial, anti-microbial, etc. It is a naphthoquinone derived yellow crystalline phytochemical constituent which is well proven for cytotoxicity against various cancer cell lines both in-vitro and in-vivo. This study is aimed to review and highlight the anticancer potential of plumbagin, formulation development approaches, and issues in the dosage form design of Plumbago zeylanica L. and its isolated constituent...
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Posted by admin on Sep 30, 2020 in |
The majority of the drugs that are available in the market which are intended for activity in the central nervous system, are not capable of being transported across the Blood-brain barrier. The nasal route of drug administration is one of the most promising routes of drug administration that can permeate the drug through BBB. The permeability of drugs across the BBB is depending on the physicochemical properties of the drugs. Drugs with molecular weight lesser than 600Daltons and partition coefficient (Log P) within the range of 1.5-2.7 might pass through the BBB. Nanocarriers are capable of getting drugs with higher molecular weight transported across the BBB. Incorporating the drug into these carriers can facilitate the transfer of drugs across BBB. SLNs and NLCs are the most prominent carrier of drugs that can be employed for the transfer of drugs to the CNS. The drugs, when administered through nasal route, are carried across the BBB mainly through two major pathways, they are olfactory pathway and trigeminal pathway. The main disadvantage...
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Posted by admin on Sep 30, 2020 in |
Acridine is a heterocyclic nucleus consisting of three fused rings heterocyclic moiety and a presence of Nitrogen in the ring structure. It is used in a large number of therapeutically agents for curing ailments like antimalarial, antiseptics, abortifacient, anticancer, and so on because of its adjuvant molecule attached to it. It possesses high pharmacological properties mainly with respect to cancer cells due to the proliferation of cells at the molecular level and acts as complexes with the peptides which bind at the molecular level for protection against the proliferation of cells. Acridine nucleus thus plays a potent role in combatting the silent and deadly disease for a better healthy nation. Acridine derivatives constitute a class of compounds that are being intensively studied as potential anticancer drugs. The most well-known acridine derivatives, their pharmacological properties, action mechanisms, and outlooks for practical application are described in this article. The unique qualities of acridines are primarily attractive due to the possibility of using them for the purpose-oriented designing of drugs. Thus, acridines...
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