Posted by admin on Sep 30, 2020 in |
The most well-known widely used route of administration among all the routes that have been explored for the systemic delivery of drugs is oral drug delivery. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. The osmotic-controlled release oral delivery system, OROS, is an advanced drug delivery technology that uses osmotic pressure as the driving force to provide pharmacotherapy, usually once daily, in several therapeutic areas. This system is independent of the physiological factors of the gastrointestinal tract and can be utilized for systemic as well as targeted delivery of drugs. Osmotic pumps consist of a core coated with a semi-permeable membrane. As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports. It mostly consists of three things a semi-permeable membrane, a core, and a delivery orifice. This paper highlights the principle of osmosis, materials used for the fabrication of pumps, types of pumps, advantages, disadvantages,...
Read More
Posted by admin on Sep 30, 2020 in |
Freeze-drying is a method of removing water by sublimation of ice crystals from frozen material. Suitable parameters of process application allow us to obtain the best quality products compared to products dried with traditional methods. In the pharmaceutical field, lyophilization has become an important subject to ongoing development and its expansion. In this 21st century, Lyophilization emerges to be a novel trend for the drying of pharmaceuticals and biological those is thermolabile or are unstable in aqueous form but stable for longer periods in their dried form. This article provides an overview on the process of lyophilization, how the freeze-drying cycle is designed, discussing several important parameters which are important for an understanding of this process as well as their role in the designing of an optimized freeze-drying cycle, so that a robust and economical process of lyophilization can be developed which does not impact the product quality. This review focused on the recent advances and its targets in the near...
Read More
Posted by admin on Sep 30, 2020 in |
Diabetes mellitus is the heterogeneous metabolic disorder caused by the high blood sugar level. Untreated high blood sugar can damage kidneys, eyes, nerves and other organs. Type 1 diabetes mellitus disorder is caused by the lack of insulin hormone while type 2 diabetes mellitus is a disorder of insulin resistance by β cells of the pancreas. For the management of type 2 diabetes mellitus different drugs are available as single or combination forms like Pioglitazone, Repaglinide, Metformin, Voglibose, Glipizide. Several research activities were carried out for its development, formulation and evaluation by the development of controlled-release and fast-dissolving formulations. The extensive literature review revealed information related to the formulation of sustain/fast release dosage form for the antidiabetic drugs. Newer techniques were used by the researcher for the formulation of dosage forms as solvent diffusion-evaporation technique, Reverse phase evaporation technique, emulsion solvent evaporation technique and Hot melt extrusion granulation technique. The review represents the types of formulation, methods used, excipients used and evaluation parameters of developed dosage forms and their...
Read More
Posted by admin on Sep 30, 2020 in |
Medicinal plants are significantly used in the cure of various ailments from ancient times. Literature suggests that traditional medicinal plants from Fabaceae, Lamiaceae, Myrtaceae, and Anacardiaceae, Combretaceae family are widely studied, and they potentially inhibit quorum sensing, a bacterial communication mechanism that leads to the pathogenesis. Plants such as Anogeissus leiocarpus, Brassia oleraceae, Camellia nitidissima, Cassia alata, Laserpitium ochridanum, Neppenthes alata, Parkia javanica, Pistacia atlantica, Plantago asiatica, Psidium guajava, Quercus infectoria, Terminallia bellerica, Terminallia catappa, are reported to be effective in quorum sensing inhibition. Plant extracts containing phytochemicals such as quercetin, kaempferol, myricetin, baicalin, cassipourol, 6-gingerol and eugenol were reported to be potential inhibitors of Pseudomonas aeruginosa quorum sensing. Bioactive principles from medicinal plants with anti-quorum sensing properties are remarkable substitutes for synthetic antibacterial drugs, especially in the era of multi-drug resistant (MDR) pathogens. The anti-quorum sensing activity of medicinal plants against the Pseudomonas aeruginosa, a gram-negative MDR bacterium, is reviewed for the period from 1997 to...
Read More
Posted by admin on Sep 30, 2020 in |
Angina Pectoris is the medical term for chest pain or discomfort due to coronary heart disease. The drawback of the marketed formulation is required repeated administration of the drug due to low bioavailability. Therefore, it utilized a nanotechnology technique for prevention of drawback of marketed formulation. Polymeric nanoparticles have been in preferential list when it comes to nano-drug delivery via oral route. Recent advances in lipid-reducing treatment, statins clinical research suggests that antimicrobial therapy is important to continue reducing cardiovascular events, beyond lipid-reducing therapy. A potential therapeutic choice for the residual risk is to intervene directly in the inflammatory process through a drug delivery system based on the nanotechnologies. Different nano-sized materials, including micelles, liposomes, polymer nano-particles, dendrimers, carbon nanotubes, and metal nanoparticles, are currently developed as by nanotechnology. It is a viable strategy since the inflammatory environment enhances the integration of nano-sized materials into a mononuclear phagocytic process. We have recently developed a polymeric nano pharmaceutical statin in order to optimize its anti-inflammatory properties. In the present review,...
Read More
