Posted by admin on Aug 31, 2020 in |
Diabetes mellitus is a metabolic disorder that causes high levels of blood glucose level in that 90% of the diabetic population accounts for type 2 diabetes mellitus it also has secondary complications like Cardiovascular disorder, Renal impairment, and susceptibility to infections. Empagliflozin is a potentially highly selective Sodium-glucose co-transportace-2 (SGLT-2) inhibitor used for the treatment of type 2 diabetes mellitus alone or in combination with the metformin or dipeptidyl peptidase-4 (DPP-4) inhibitors. The literature entitles the various analytical techniques like UV spectroscopy, High Performance Liquid Chromatography, High Performance Thin Layer Chromatography, Liquid Chromatography-Mass spectrometry. In this literature, we reviewed the various analytical, stability studies, impurity profiling and bio-analytical methods used for the estimation of Empagliflozin. This review gives the concise and collective information about the analytical validating parameters like Limit of detection (LOD), Limit of Quantification (LOQ), Standard Curve, Accuracy & Precision for the analysis of Empagliflozin alone or in combination with the Linagliptin or Metformin. This review helps to carryout further analytical studies on the mentioned...
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Posted by admin on Aug 31, 2020 in |
The medicinal properties of Garlic are well known for a long time. Garlic is recommended as a nutritive element in the treatment of various health problems and the prolongation of human life. The present review article on garlic is to explore ancient phytomedicinal uses with modern scientific knowledge. Garlic cloves contain a colorless, odorless, soluble compound called alliin, water, and vascular enzyme alliinase. As soon as garlic clove is cut, alliin is converted to allicin by the action of enzyme alliinase. Pungent garlic smell is due to allicin. Modern scientific studies have revealed the beneficial effects of garlic on the cardiovascular system, Alzheimer’s disease, diabetes, wound healing, neuro/ nephroprotection, osteoporosis, stress, aging, and anti-fungal/bacterial/viral/ Protozoans. Though, it is commonly used in food items, yet it is also recommended as pesticide/insecticide/molluscicide. The present review deals with the diversified beneficial activity of the garlic in the welfare of human beings. Although recent researches on its medicinal properties had explored its therapeutic value in the treatment of various ailments, yet a lot...
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Posted by admin on Aug 31, 2020 in |
Mangrove plants are used in medicines, and extracts from mangrove species have proven inhibitory activity against human, animal, and plant pathogens. Endophytic fungi are an important component, are universal, and occur within all know plants, including a broad range of hosts in various ecosystems, and therefore play an important role in the natural environment. Numerous species of mangrove produce bioactive compounds that can control microbial growth. Mangrove extracts can also be the likely sources of mosquito larvicides, antifungal, antiviral, anti-cancer, and anti-diabetic complexes. Mangrove endophytic fungi with promising antioxidant activities that may be useful to humans as novel physiological agents. The present review deals with the endophytic fungi from mangrove...
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Posted by admin on Aug 31, 2020 in |
As humanity is progressing, many new borne infections are borne, and the stability and efficiency of the human body are being tested. Today the World is fighting with a deadly Novel infection named Corona Virus Disease. The aim of this systematic review is to find out the efficacy of Nutritional Interventions against the infections caused in the body due to pathogens. Further, the recommendations can be made for further researches based on the evidence collected. To collect the data, electronic databases such as Scopus, Pub Med, NCBI, and web of science have been used. The peer-reviewed journals and newspaper reports are being cited with the English language. The papers were published from 1989 to 2020. Finally, a total of twelve studies were identified, and the pathways of all nutrient metabolisms are included in the study. The studies were mostly carried out in Asian and European countries on human as well as animals. All the studies except one supported the role of Nutrients in preventing and curing the infection caused...
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Posted by admin on Aug 31, 2020 in |
Benzimidazole, a fused heterocyclic moiety containing benzene and imidazole, has gained considerable attention in the field of medicinal chemistry due to its wide array of pharmacological activities. Be it as a antifungal, anticancer agent, proton pump inhibitors, anthelmintic, anti-microbial, analgesic, it has become an intrinsic part of the pharmaceutical world. The presence of Nitrogen in its heterocyclic ring has made it a more biologically active pharmaceutical agent. The fact that benzimidazole residue is a constituent of vitamin B12 supports its potential use in therapeutics. Benzimidazole derivatives are the structural isosters of naturally occurring nucleotides such as purine, allow them to interact effectively with the biopolymers of the living system such as proteins, enzymes, and receptors. Benzimidazoles exhibit significant activity as a potential anti-tumour agent, smooth muscle cell proliferation inhibitors, a treatment for intestinal cystitis, and in a diverse area of medicinal chemistry. The synthesis of novel benzimidazole derivatives remains as the main focus of medicinal research. This current review covers the chemistry and significance of benzimidazole and its derivatives,...
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