Posted by admin on Sep 30, 2020 in |
Varieties of natural products have been proved as a rich source of phytoconstituents which are reported for a wide range of therapeutic potential. Plumbago zeylanica L. Is one of the herbs which are traditionally used for its therapeutic value. It is reported for several bioactive chemical constituents like naphthoquinones, flavonoids, alkaloids, glycosides, steroids, tri-terpenoids, tannins, fixed oils, fats, proteins, etc. in its chemical composition. Plumbagin is one of the most bioactive compounds of Plumbago zeylanica L., which is reported for a wide range of pharmacological activities such as anti-cancer, anti-diabetic, anti-malarial, anti-microbial, etc. It is a naphthoquinone derived yellow crystalline phytochemical constituent which is well proven for cytotoxicity against various cancer cell lines both in-vitro and in-vivo. This study is aimed to review and highlight the anticancer potential of plumbagin, formulation development approaches, and issues in the dosage form design of Plumbago zeylanica L. and its isolated constituent...
Read More
Posted by admin on Sep 30, 2020 in |
The majority of the drugs that are available in the market which are intended for activity in the central nervous system, are not capable of being transported across the Blood-brain barrier. The nasal route of drug administration is one of the most promising routes of drug administration that can permeate the drug through BBB. The permeability of drugs across the BBB is depending on the physicochemical properties of the drugs. Drugs with molecular weight lesser than 600Daltons and partition coefficient (Log P) within the range of 1.5-2.7 might pass through the BBB. Nanocarriers are capable of getting drugs with higher molecular weight transported across the BBB. Incorporating the drug into these carriers can facilitate the transfer of drugs across BBB. SLNs and NLCs are the most prominent carrier of drugs that can be employed for the transfer of drugs to the CNS. The drugs, when administered through nasal route, are carried across the BBB mainly through two major pathways, they are olfactory pathway and trigeminal pathway. The main disadvantage...
Read More
Posted by admin on Sep 30, 2020 in |
Acridine is a heterocyclic nucleus consisting of three fused rings heterocyclic moiety and a presence of Nitrogen in the ring structure. It is used in a large number of therapeutically agents for curing ailments like antimalarial, antiseptics, abortifacient, anticancer, and so on because of its adjuvant molecule attached to it. It possesses high pharmacological properties mainly with respect to cancer cells due to the proliferation of cells at the molecular level and acts as complexes with the peptides which bind at the molecular level for protection against the proliferation of cells. Acridine nucleus thus plays a potent role in combatting the silent and deadly disease for a better healthy nation. Acridine derivatives constitute a class of compounds that are being intensively studied as potential anticancer drugs. The most well-known acridine derivatives, their pharmacological properties, action mechanisms, and outlooks for practical application are described in this article. The unique qualities of acridines are primarily attractive due to the possibility of using them for the purpose-oriented designing of drugs. Thus, acridines...
Read More
Posted by admin on Sep 30, 2020 in |
The most well-known widely used route of administration among all the routes that have been explored for the systemic delivery of drugs is oral drug delivery. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. The osmotic-controlled release oral delivery system, OROS, is an advanced drug delivery technology that uses osmotic pressure as the driving force to provide pharmacotherapy, usually once daily, in several therapeutic areas. This system is independent of the physiological factors of the gastrointestinal tract and can be utilized for systemic as well as targeted delivery of drugs. Osmotic pumps consist of a core coated with a semi-permeable membrane. As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports. It mostly consists of three things a semi-permeable membrane, a core, and a delivery orifice. This paper highlights the principle of osmosis, materials used for the fabrication of pumps, types of pumps, advantages, disadvantages,...
Read More
Posted by admin on Sep 30, 2020 in |
Freeze-drying is a method of removing water by sublimation of ice crystals from frozen material. Suitable parameters of process application allow us to obtain the best quality products compared to products dried with traditional methods. In the pharmaceutical field, lyophilization has become an important subject to ongoing development and its expansion. In this 21st century, Lyophilization emerges to be a novel trend for the drying of pharmaceuticals and biological those is thermolabile or are unstable in aqueous form but stable for longer periods in their dried form. This article provides an overview on the process of lyophilization, how the freeze-drying cycle is designed, discussing several important parameters which are important for an understanding of this process as well as their role in the designing of an optimized freeze-drying cycle, so that a robust and economical process of lyophilization can be developed which does not impact the product quality. This review focused on the recent advances and its targets in the near...
Read More
