Posted by admin on May 31, 2020 in |
From bench to bedside, clinical research had always played as a convenient tool in the field of cancer biology to inquire about the effectiveness of different anticancer drugs on different human-derived cancer cell lines. According to the American Cancer Society, nearly 4000 new cases and 1600 deaths predicted in 2019 in the United States. Besides, to these alarming statistics, rising cost and health-related complications associated with treatments had made the research of cell lines on the anticancer drug more relevant. This article providing a comprehensive review of cancer, advanced development of the anticancer drugs, and a brief inference on progression-free survival rate (PFS) of the following anticancer and engineered monoclonal antibody drugs are...
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Posted by admin on May 31, 2020 in |
Doxorubicin (DOX), an anthracycline antibiotic that is highly used for cancer treatment (chemotherapy), but its chemotherapeutic application is limited due to its cardiotoxicity. The major mechanism of doxorubicin action as the free radical formation and as an inhibiter of topoisomerase II and other signaling pathways is also invoked significant consequence for the cardiomyocyte. But the years of clinical use of doxorubicin generates a need for monitoring the procedure of cardiotoxicity as well as understanding its potential. Peak plasma concentration plays a key role in causing cardiotoxicity and antineoplastic activity. There are two mechanisms, the first one is anti-tumor action, and second one is cardiotoxicity. Cardiotoxicity mechanism has several pathways 1) formation of reactive oxygen and nitrogen species 2) interaction of calcium overload 3) disturb the serum biomarker levels 4) DNA damage. These are the main pathways to cause cardiotoxicity. Some signs and symptoms are given to identify doxorubicin cardiotoxicity like echocardiographical changes, angiographic changes, and disturbance in the serum biomarkers level like GSH, LDH and CK-MB. Some drugs are...
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Posted by admin on May 31, 2020 in |
Dandruff is a well-known and global consumer problem, characterized by flaking and scaling of the scalp, with itching and irritation. Although it is not a life-threatening disease, but it is directly related to individual self-esteem, confidence, and beauty. Approximately half of the population is suffering from dandruff and expending around billions of dollars, including hospital services and counter products. Despite its frequency, much controversy remains regarding the pathogenesis of dandruff. Many studies postulated that dandruff is caused by various microbial and non–microbial factors and interaction between them, such as Malassezia fungi, sebum secretion, and individual susceptibility. But some recent researches also claimed that dandruff is not only produced by fungi but there are some bacteria that also play a significant role in accelerating dandruff. The present treatment includes antifungal agents, no doubt, they have significant results but with lots of side effects and limitations. So, there’s a need to formulate a cost-effective product that possesses anti-dandruff activity, and Zulamla (Hamdard Laboratory Patent Product) is used and is in the...
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Posted by admin on May 31, 2020 in |
Herbal medicine has been widely accepted as a promising approach for the treatment of various diseases with lower cost and minimized toxicity. Bioactive constituents isolated from the herbal source are equipped with synthetic drugs. The potency of any herbal medication is contingent on the delivery of the effectual level of the therapeutically active constituent. The integration of a novel drug delivery system in a traditional system of medicine enriches the potentiality of herbal drugs. Several plant extracts and phytoconstituents, despite having excellent bio-activity in-vitro demonstrate less or no in-vivo actions due to their poor lipid solubility or improper molecular size or both, resulting in poor absorption and poor bioavailability. Nan technological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus, obtain a greater bioavailability. Phytosome technology is one such novel approach that enabled in making phytoconstituents more bioavailable. In this review, a comprehensive discussion with respect to the methods and characterization of nanophytosomes of herbal preparations is...
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Posted by admin on May 31, 2020 in |
Cancer is the major cause of mortality in most of the developing countries. Recent times have seen an exceptional advancement in cancer biology Research. Researchers undertook the development of enormous chemotherapeutic agents. Pim family of serine/threonine kinases regulated by calcium/calmodulin have been identified as unique molecular targets in oncogenesis. It constitutes three members: Pim-1, Pim-2, and Pim-3 discovered by cloning the proviral integration site in Moloney murine leukemia virus (M-MuLV). Pim-1 was found to bear two isoforms Pim-1S and Pim-1L. It plays a dominant role in various processes of cell regulation like replicative senescence, drug resistance, apoptosis, epidynamics regulator, diagnostic tool, prostate cancer biomarker, and an immunotherapy agent. An insight into the structure of Pim kinases by crystal studies laid down a molecular basis for the development of selective and synergistic anti-cancer therapies. These proto-oncogenes are overexpressed in B lymphoid, myeloid cell lines, hematopoietic malignancies, and prostate cancer. This review emphasizes the importance and role of Pim-1 kinase in various molecular signaling pathways involved in tumorigenesis and the potential...
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