Posted by admin on Sep 30, 2020 in |
Diabetes mellitus is the heterogeneous metabolic disorder caused by the high blood sugar level. Untreated high blood sugar can damage kidneys, eyes, nerves and other organs. Type 1 diabetes mellitus disorder is caused by the lack of insulin hormone while type 2 diabetes mellitus is a disorder of insulin resistance by β cells of the pancreas. For the management of type 2 diabetes mellitus different drugs are available as single or combination forms like Pioglitazone, Repaglinide, Metformin, Voglibose, Glipizide. Several research activities were carried out for its development, formulation and evaluation by the development of controlled-release and fast-dissolving formulations. The extensive literature review revealed information related to the formulation of sustain/fast release dosage form for the antidiabetic drugs. Newer techniques were used by the researcher for the formulation of dosage forms as solvent diffusion-evaporation technique, Reverse phase evaporation technique, emulsion solvent evaporation technique and Hot melt extrusion granulation technique. The review represents the types of formulation, methods used, excipients used and evaluation parameters of developed dosage forms and their...
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Posted by admin on Sep 30, 2020 in |
Medicinal plants are significantly used in the cure of various ailments from ancient times. Literature suggests that traditional medicinal plants from Fabaceae, Lamiaceae, Myrtaceae, and Anacardiaceae, Combretaceae family are widely studied, and they potentially inhibit quorum sensing, a bacterial communication mechanism that leads to the pathogenesis. Plants such as Anogeissus leiocarpus, Brassia oleraceae, Camellia nitidissima, Cassia alata, Laserpitium ochridanum, Neppenthes alata, Parkia javanica, Pistacia atlantica, Plantago asiatica, Psidium guajava, Quercus infectoria, Terminallia bellerica, Terminallia catappa, are reported to be effective in quorum sensing inhibition. Plant extracts containing phytochemicals such as quercetin, kaempferol, myricetin, baicalin, cassipourol, 6-gingerol and eugenol were reported to be potential inhibitors of Pseudomonas aeruginosa quorum sensing. Bioactive principles from medicinal plants with anti-quorum sensing properties are remarkable substitutes for synthetic antibacterial drugs, especially in the era of multi-drug resistant (MDR) pathogens. The anti-quorum sensing activity of medicinal plants against the Pseudomonas aeruginosa, a gram-negative MDR bacterium, is reviewed for the period from 1997 to...
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Posted by admin on Sep 30, 2020 in |
Angina Pectoris is the medical term for chest pain or discomfort due to coronary heart disease. The drawback of the marketed formulation is required repeated administration of the drug due to low bioavailability. Therefore, it utilized a nanotechnology technique for prevention of drawback of marketed formulation. Polymeric nanoparticles have been in preferential list when it comes to nano-drug delivery via oral route. Recent advances in lipid-reducing treatment, statins clinical research suggests that antimicrobial therapy is important to continue reducing cardiovascular events, beyond lipid-reducing therapy. A potential therapeutic choice for the residual risk is to intervene directly in the inflammatory process through a drug delivery system based on the nanotechnologies. Different nano-sized materials, including micelles, liposomes, polymer nano-particles, dendrimers, carbon nanotubes, and metal nanoparticles, are currently developed as by nanotechnology. It is a viable strategy since the inflammatory environment enhances the integration of nano-sized materials into a mononuclear phagocytic process. We have recently developed a polymeric nano pharmaceutical statin in order to optimize its anti-inflammatory properties. In the present review,...
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Posted by admin on Aug 31, 2020 in |
Diabetes mellitus is a metabolic disorder that causes high levels of blood glucose level in that 90% of the diabetic population accounts for type 2 diabetes mellitus it also has secondary complications like Cardiovascular disorder, Renal impairment, and susceptibility to infections. Empagliflozin is a potentially highly selective Sodium-glucose co-transportace-2 (SGLT-2) inhibitor used for the treatment of type 2 diabetes mellitus alone or in combination with the metformin or dipeptidyl peptidase-4 (DPP-4) inhibitors. The literature entitles the various analytical techniques like UV spectroscopy, High Performance Liquid Chromatography, High Performance Thin Layer Chromatography, Liquid Chromatography-Mass spectrometry. In this literature, we reviewed the various analytical, stability studies, impurity profiling and bio-analytical methods used for the estimation of Empagliflozin. This review gives the concise and collective information about the analytical validating parameters like Limit of detection (LOD), Limit of Quantification (LOQ), Standard Curve, Accuracy & Precision for the analysis of Empagliflozin alone or in combination with the Linagliptin or Metformin. This review helps to carryout further analytical studies on the mentioned...
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Posted by admin on Aug 31, 2020 in |
The medicinal properties of Garlic are well known for a long time. Garlic is recommended as a nutritive element in the treatment of various health problems and the prolongation of human life. The present review article on garlic is to explore ancient phytomedicinal uses with modern scientific knowledge. Garlic cloves contain a colorless, odorless, soluble compound called alliin, water, and vascular enzyme alliinase. As soon as garlic clove is cut, alliin is converted to allicin by the action of enzyme alliinase. Pungent garlic smell is due to allicin. Modern scientific studies have revealed the beneficial effects of garlic on the cardiovascular system, Alzheimer’s disease, diabetes, wound healing, neuro/ nephroprotection, osteoporosis, stress, aging, and anti-fungal/bacterial/viral/ Protozoans. Though, it is commonly used in food items, yet it is also recommended as pesticide/insecticide/molluscicide. The present review deals with the diversified beneficial activity of the garlic in the welfare of human beings. Although recent researches on its medicinal properties had explored its therapeutic value in the treatment of various ailments, yet a lot...
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