Posted by admin on Dec 31, 2019 in |
Bacteria predominantly remain in a self-produced polymeric matrix, adherent to an inert or living surface. This microenvironment community of bacteria is known as biofilm. Commonly visualized as a slimy layer, a number of unique features distinguish biofilms from their planktonic counterparts. Formation of biofilms depends on the extracellular signals, mechanical, biochemical, environmental conditions and genetic factors in bacteria. The attachment of biofilms is an intriguing process which is regulated by several characteristics such as substratum, cell surface, and growth medium. These biofilms cause various infections and are of at most importance when concerned about public health. One of the challenges faced during antibacterial drug development is to create compounds to counter-attack the biofilm infections. In this study, antibiofilm activities of five essential oils (EUGENOL; CINNAMALDEHYDE; PIPERIDINE; LIMONENE) were discussed. This review consisting of explicit evidence proved that plants are indeed a wonderful source to provide naturally occurring compounds for development of therapeutic and preventive agents against infections caused by...
Read More
Posted by admin on Dec 31, 2019 in |
Depression is a common heterogeneous, debilitating and life-threatening mood disorder affecting different segments of the community. Several chemical and synthetic medicines as standard are being employed to treat depression and may lead to complete recovery in only 50% of clinically depressed patients but causes many adverse effects. Thus, scientists are increasing their interest in research towards the utility of medicinal plants for antidepressant activity. Several medicinal plants and its derived medicinal products have been reported to exert antidepressant action in different animal models by the combined effect of their phytoconstituents. In the brain, the alteration in level of various endogenous molecules likes noradrenaline (NA), acetylcholine (Ach), serotonin (5-HT), dopamine, glucocorticoid, γ-aminobutyric acid (GABA), corticotrophin-releasing hormone (CRH) and hippocampal volume are responsible for depression. Therefore, most medicinal plants through synaptic regulation of serotonin, noradrenaline, and dopamine, overcome the altered level of monoamines in the brain and also reinforcing antioxidant defense mechanism, regulate hypothalamic-pituitary-adrenal axis activity and reducing inflammatory mediators. So, herbal medicines are widely used in contrast to allopathic or...
Read More
Posted by admin on Dec 31, 2019 in |
PTEN (phosphatase and tension homolog deleted on chromosome 10) is an important key factor in regulating intracellular for cell growth and proliferation by blocking the phosphatidylinositol -3kinase/ AKT protein kinase B (PI3K/Akt) pathway alteration in PTEN is concomitant with many diseases. PTEN is recurrently mutated in several pathological diseases which indicate its significance in general physiological activity. Various cellular proteins are initiated by phosphorylation; in contrast, PTEN is deactivated based on phosphorylation by specific kinases. Therefore, the development of therapeutic agents includes selectively targeting quickness and kinase-domain containing proteins affecting PTEN associated diseases. The present review focuses on the role of PTEN in pathological conditions and a comprehensive list of currently identified modulators of PTEN and explains potential new molecular targets which could be help in the development of drugs for the management of PTEN associated diseases like cardiovascular diseases, diabetes, obesity, cancer, autism, and Alzheimer’s...
Read More
Posted by admin on Nov 30, 2019 in |
Cancer is a genetic disorder that can happen to anybody; anytime. The treatment, where one or more chemotherapeutic agents (anti-cancer drugs) are used either to treat the cancer patients (curative intent with one or combination of anti-cancer drugs) or to prolong the life and to reduce the symptoms in cancer patients is known as Chemotherapy. But nowadays it is observed that when these chemotherapeutic agents are administered in the cancer patients for prolonged period then the drugs stop showing the required response and thus results in the failure of the treatment. This is called Multiple Drug Resistance (MDR). Various treatments are coming up recently, and combination therapy of chemotherapeutic agent and chemosensitizer molecule is one of the effective approaches to combat the Multidrug Resistance of anti-neoplastic drugs in cancer cells. This paper reviews MDR associated with cancer, therapies to overcome the resistance and studies to confirm the...
Read More
Posted by admin on Nov 30, 2019 in |
Introduction: Juvenile idiopathic arthritis (JIA) is chronic inflammatory arthritis in children and adolescents. The symptoms present in JIA are more comparable with features of Aamavata Vyadhi mentioned in Ayurvedic classics. JIA can be treated by Shodhana and Shaman therapy of Ayurveda which is free from any side effects. The main aim of this article is to elaborate on JIA and its treatment by different modalities of Ayurveda. Methodology: This review work was carried out by using a widespread and planned data mining approach. To achieve significant literature author uses the keywords “Juvenile idiopathic arthritis” “Shodhana therapy in JIA” “JIA treatment by Ayurveda” and “herbal medicine for JIA” searched in Google Scholar, web of science, Science direct, Scopus, Medline, and PubMed Central journal literature. Observation: Nine publications were included in the final selection after systematic analysis. Conclusion: In Ayurveda, Shodhna therapy such as Sarvaanga Abhangya (Full body massage with medicated oil), Nadi swedana (Steam bath), Valuka Swedana (fomentation by sand pack) and Vaitarana Basti (type of medicated enema) is very...
Read More
