Posted by admin on May 31, 2020 in |
Dandruff is a well-known and global consumer problem, characterized by flaking and scaling of the scalp, with itching and irritation. Although it is not a life-threatening disease, but it is directly related to individual self-esteem, confidence, and beauty. Approximately half of the population is suffering from dandruff and expending around billions of dollars, including hospital services and counter products. Despite its frequency, much controversy remains regarding the pathogenesis of dandruff. Many studies postulated that dandruff is caused by various microbial and non–microbial factors and interaction between them, such as Malassezia fungi, sebum secretion, and individual susceptibility. But some recent researches also claimed that dandruff is not only produced by fungi but there are some bacteria that also play a significant role in accelerating dandruff. The present treatment includes antifungal agents, no doubt, they have significant results but with lots of side effects and limitations. So, there’s a need to formulate a cost-effective product that possesses anti-dandruff activity, and Zulamla (Hamdard Laboratory Patent Product) is used and is in the...
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Posted by admin on May 31, 2020 in |
Herbal medicine has been widely accepted as a promising approach for the treatment of various diseases with lower cost and minimized toxicity. Bioactive constituents isolated from the herbal source are equipped with synthetic drugs. The potency of any herbal medication is contingent on the delivery of the effectual level of the therapeutically active constituent. The integration of a novel drug delivery system in a traditional system of medicine enriches the potentiality of herbal drugs. Several plant extracts and phytoconstituents, despite having excellent bio-activity in-vitro demonstrate less or no in-vivo actions due to their poor lipid solubility or improper molecular size or both, resulting in poor absorption and poor bioavailability. Nan technological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus, obtain a greater bioavailability. Phytosome technology is one such novel approach that enabled in making phytoconstituents more bioavailable. In this review, a comprehensive discussion with respect to the methods and characterization of nanophytosomes of herbal preparations is...
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Posted by admin on May 31, 2020 in |
Cancer is the major cause of mortality in most of the developing countries. Recent times have seen an exceptional advancement in cancer biology Research. Researchers undertook the development of enormous chemotherapeutic agents. Pim family of serine/threonine kinases regulated by calcium/calmodulin have been identified as unique molecular targets in oncogenesis. It constitutes three members: Pim-1, Pim-2, and Pim-3 discovered by cloning the proviral integration site in Moloney murine leukemia virus (M-MuLV). Pim-1 was found to bear two isoforms Pim-1S and Pim-1L. It plays a dominant role in various processes of cell regulation like replicative senescence, drug resistance, apoptosis, epidynamics regulator, diagnostic tool, prostate cancer biomarker, and an immunotherapy agent. An insight into the structure of Pim kinases by crystal studies laid down a molecular basis for the development of selective and synergistic anti-cancer therapies. These proto-oncogenes are overexpressed in B lymphoid, myeloid cell lines, hematopoietic malignancies, and prostate cancer. This review emphasizes the importance and role of Pim-1 kinase in various molecular signaling pathways involved in tumorigenesis and the potential...
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Posted by admin on May 31, 2020 in |
Ageratina adenophora, often known as Crofton Weed, is one of the common invasive weeds which first originated from Mexico and Central America and gradually invaded numerous parts of the world. Because of its ability to alter the soil microbial communities and its allelopathic competition with other plant species, this plant colonizes forest margins, stream banks and disturbed areas in large dense clumps and is found to possess potent toxicological effects on livestock; the lethal chronic pulmonary disease has been reported in horses while liver complications have been reported in mice. Despite this, the plant has been studied more extensively for its therapeutic uses as phytochemicals viz. steroids, tannins, triterpenes, coumarins and saponins (7-hydroxy-dehydrotremetone, 7, 10,1 1-trihydroxy-dehydrotremetone, 10-oxo-7-hydroxynordehydro-tremetone,Eupatorone, 2-deoxo-2-(acetyloxy)-9-oxoagera-phorone(DAOA), 9-oxoagerophorone(OA), etc.) which have been reported are found to possess antimicrobial activity, antipyretic activity, wound healing, antioxidant activity, analgesic activity, anti-tumor activity, insecticidal activity, antiviral activity, anti-inflammatory activity, larvicidal activity. This present review is an effort to give a detailed survey of the literature on invasive nature, pharmacological study, phytochemical review,...
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Posted by admin on May 31, 2020 in |
Substances that loose stools and boost bowel movements are laxatives, purgatives, or aperitives. They are used to treat constipation and to stop it. Constipation relates to infrequent or difficult to transfer bowel movements. Often the stool is hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if the bowel movement has not been fully passed. Hemorrhoid’s anal fissure or fecal impaction may be complications from constipation. It is a common gastrointestinal functional disorder. IBS is considered to be a complex condition with physiological and psychosocial elements in which stimuli from the central nervous system modulates altered bowel motility or sensation. Medical treatments for constipation include the provision of bulk laxatives, osmotic agents, stimulants, lubricants, and neuromuscular agents. Animal models are important tools in experimental medical science to understand the pathological process of human diseases. Animal models include drug-induced constipation in rat model, canine slow transit constipation model, low-fiber diet-induced constipation in rats, gastrointestinal motility test, castor oil-induced enter pooling. Gastrointestinal motility depicts the muscle contraction...
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