Posted by admin on Feb 29, 2020 in |
Drug delivery to targeted sites is restricted by various barriers. The conventional drug delivery systems like tablets, capsules, suspensions, emulsions, elixirs, lotions etc. are being encountered with a number of issues such as poor bioavailability, drug shelf life, drug-excipients incompatibilities and patient in compliance. Thus with the advent of novel drug delivery systems such as liposomes; nanoparticles are proving to be a better option nowadays. As evolution in the drug delivery system, a new system with lesser side effects was introduced in 2011 known as Spanlastics. They are elastic, deformable surfactant-based nanovesicles in which an aqueous solute solution is entirely enclosed. They are shown to be chemically more stable. They provide targeting and controlled release of natural pharmaceutical compounds and have improved several drawbacks of the conventional dosage form. The current review emphasizes the utility of spanlastics, mechanism of penetration, different preparation approaches, their evaluation parameters and...
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Posted by admin on Feb 29, 2020 in |
Chromens are oxygen-containing heterocycles, abundantly found in nature in the form of flavone, is flavones, flavanones, catechins, anthocyanins and collectively known as flavonoids and isoflavonoids. Being a polar and ionizable aromatic compound, it improves the pharmacokinetic characteristics of lead molecules. Imidazole derivatives have occupied a unique place in the field of medicinal chemistry. Therefore, the incorporation of the chromen nucleus is an important synthetic strategy in drug discovery. The high therapeutic properties of the chromen related drugs have encouraged the researchers to synthesize new chemotherapeutic agents. A variety of cellular targets are interacting with the derivatives of chromen and that can be responsible for their wide-ranging epileptic activities. The substitution of chromen nucleus is a crucial step in the drug discovery process. In the present review, chromen derivatives having antiepileptic activity is described using a structural substitution pattern. The interest in chromen is ever-growing since they offer a fairly diverse chemical space for exploration of medicinal...
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Posted by admin on Feb 29, 2020 in |
Hollow microballoons (microspheres) are spherical empty particles without core. Microballoons (Hollow microsphere) are a drug delivery system that promises to be a potential approach for gastric retention. Microballoons drug-delivery systems are based on a non-effervescent system containing empty particles of spherical shape without core ideally having a size less than 200 micrometers. Microballoons drug delivery systems have shown to be of better significance in controlling the release rate for drugs having site-specific absorption. The floating microballoons showed gastro retentive controlled release delivery with efficient means of enhancing the bioavailability and promises to be a potential approach for gastric retention. Optimized hollow microspheres will find the central place in novel drug delivery, particularly in safe, targeted and effective in-vivo delivery promises to be a potential approach for gastric retention. They are gastro retentive drug-delivery systems, which provide controlled release properties. The advantages, limitations, methods of preparation of hollow microsphere, applications, polymers used in hollow microspheres, characterizations of microballoons and formulation aspects with various evaluation techniques and marketed products are covered in...
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Posted by admin on Feb 29, 2020 in |
Green analytical chemistry is an attempt to reduce the environmental hazards caused by chemicals and chemical processes. To avoid the use or formation of dangerous materials, the best way is to prevent pollution rather than cleaning up the process. Therefore, it is important to choose a method with the least harmful effects on the environment. The main focus or aim of green chromatography is to make a method greener at each and every step of analysis from sample collection to its determination. The present review includes the goals to achieve green chromatography using environmentally benign solvents and reagents, most recent contribution in the development of greener sample preparation since it has effect on whole analytical methodology, chromatographic separation techniques, advantages of green chromatography, green microextraction techniques (solid-phase microextraction, still bar sorptive, liquid-phase microextraction) are included. The aim is to make chromatographic separations greener, depending on the type of chromatography which includes the solventless extraction...
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Posted by admin on Feb 29, 2020 in |
The article focuses on the prevalence of obesity in India, increasing levels of childhood obesity, and the potential health hazards that result from obesity, thereby suggesting the necessary preventive measures and the prevailing natural and synthetic therapy that can help to cure the disease, thus spreading awareness about its severity and necessity for treatment. Obesity in India has reached epidemic proportions in the 21st century, with morbid obesity affecting 5% of the country’s population. About 3.4 million people die each year due to overweight and obesity. The numbers are only worsening with each passing year. Anti-obesity medication or weight loss drugs are pharmacological agents that reduce or control weight. These drugs alter one of the fundamental processes of the human body, weight regulation, by altering either appetite or absorption of calories. Thus proper preventive measures and medication can help in reducing the extent of the disease...
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