Posted by admin on Aug 31, 2019 in |
Proteins interact in the cellular arena to carry out a majority of the vital functions of the cells. After exploring the transcriptome, the researchers are now targeting to investigate the interactome of a cell. This can help to design more efficient drug and vaccine formulations and therapeutic targets benefiting humankind in every possible way. Advancement in protein and protein networking databases gives the first insight to study such macromolecular interactions paving the way for their in-vitro and in-vivo analysis. However, none of the technique can promise 100% efficiency alone due to some limitations like time, cost, and false positive results. Combination of one or more techniques can enhance data quality and reliability. Recent advancements in the studies of the protein-protein interaction using computational methods have led the identification of different signaling pathways and protein complex involved in various specific diseases. However, the major challenge faced is to verify the results obtained from the virtual prediction software’s. In this review, we have focused on how different techniques have been accustomed...
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Posted by admin on Aug 31, 2019 in |
Surface disinfectant is the multi-billion-dollar global industry with continuous growth opportunities linked to advancements in technology and innovations. However, innovations and new advancements do not always reach consumers due to the lack of clarity related to the approval process of such innovations and stringent regulations by national health authorities. These regulations can pose challenges for innovators, manufacturers, importers & exporters to obtain market authorizations. This article provides an overview of the disinfectant regulations globally and understands the need for...
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Posted by admin on Jul 31, 2019 in |
There are different types of conventional approaches are used for the synthesis of nanoparticles like physical and chemical techniques. But above approaches used for nanoparticles synthesis is not eco-friendly due to the production of toxic compounds during nanoparticles formation. Therefore, interest in the green synthesis of nanoparticles has been increased. The green synthesis of nanoparticles is an eco-friendly and convenient approach in which there are no adverse effects on the environment. The production of nanoparticles by green synthesis minimizes time and can obtain desired size and shape to increase the constancy of nanoparticles. The living organisms like plant, bacteria, algae, and fungi are known to be capable for production of metals nanoparticles through the intracellular or extracellular mode of biosynthesis. The main reason of involvement of plants, algae especially microorganisms in the production of metal nanoparticles are to develop, immaculate, harmless and environmentally protected production processes for nano synthesis to diminish environmental impact, minimize waste and boost energy efficiency. Therefore, the present review focus on methods concerned on the...
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Posted by admin on Jul 31, 2019 in |
Mushrooms can be considered as a prolific resource for drugs as per previous literature surveys. Their constituent bioactive components are broadly classified such as phenols, flavonoids, triterpenoids, saponins. Whole mushrooms or mainly fruiting bodies extracts and compounds isolated from their mycelium are of immense pharmacological importance. Extraction employing suitable solvents leads to the isolation of various principle compounds. Pure compounds can also be isolated from natural material or can be synthesized chemically. 80-85% of all medicinal mushroom products are isolated from fruiting bodies. 15% of all products are obtained from mycelia. Cultivation of mushrooms requires minimal resources; therefore the development of cultivation farm helps for creating employment for various people in many parts of the country. Many kinds of literature have already reported the detailed chemical bioactive constituents of the extracts prepared from mushrooms via various extraction methods. These compounds are of immense therapeutic importance, and some of them have already become a part of clinical trials as an adjuvant therapy along with the conservative therapy applied for patients...
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Posted by admin on Jul 31, 2019 in |
Angiogenesis is the formation of new blood vessels from preexisting vasculature. It is a key process in some physiological conditions such as wound healing, growth and reproduction. Any disturbance in mechanisms of angiogenesis plays a key role in the pathogenesis of some diseases through the over-proliferation of blood vessels such as cancers, psoriasis, arthritis, retinopathies, obesity, asthma, and atherosclerosis and cardiovascular diseases, which have the highest rates of morbidity and mortality worldwide. Anti-angiogenic therapy has been proved to be a potential cure in the past decades for a number of cancers. Still, antiangiogenic therapy has to be realized to its fullest potential to turn cancer into a dormant disease. Many angiogenic inhibitors have been developed till date, and the main problem is the multiple angiogenic molecules produced by tumors and tumors at different stages of development. Therefore, blocking a single angiogenic molecule has less effect or no effect. Selection of a suitable model for angiogenesis research remains a challenge. Thus, in recent years, several models for evaluation of angiogenesis...
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