Posted by admin on Jan 31, 2020 in |
Coenzyme Q10 (ubiquinone) is a lipophilic benzoquinone substance. It is a pivotal component to the oxidative phosphorylation in the inner mitochondrial membrane of all aerobic cells as well as diminishes reactive oxygen species (ROS). Exogenous sources for CoQ10 are grapes seed oil, walnuts, pistachios, spinach, and sesame seed. At present, it is being utilized as an antioxidant agent. Recent studies have revealed its neuroprotective action. In the present review, the comprehensive pharmacological benefits of coenzyme Q10 on the central nervous system (CNS) has been revealed. Many studies were taken into considerations and compiled in accordance with their activities. Amongst those, the study using in-vitro models referring to neuronal toxicity and animal models of neurodegenerative diseases have been covered. Multiple outcomes have now evolved assisting the role of reactive oxygen species and neuroinflammation in the pathogenesis of the neurodegenerative disorder. The drug coenzyme Q10 has been administered in a human subject with reference to their age and body weight. In case of increased oxidative stress and few selective cases of...
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Posted by admin on Jan 31, 2020 in |
Plants are a valuable source of secondary metabolites. Many phytochemicals are obtained from the plant sources that are used as valuable medicinal agents. Chalcones are one of the important secondary metabolites obtained from many edible plants like foods, vegetables, tea, spices and natural foodstuffs. Chalcones considered as obligate intermediated in flavonoid biosynthesis but they do not accumulate to an appreciable degree in most plants. Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family that possess a wide variety of cytoprotective and modulatory functions, which may have therapeutic potential for multiple diseases. The largest number of natural chalcones has been isolated from species of the Leguminosae, Asteraceae and Moraceae families. Chalcone accumulating plants have often been used in traditional medicine and These chalcones and their derivatives have shown important antimicrobial, antifungal, anti-mycobacterial, antimalarial, antiviral, anti-inflammatory, antioxidant, anti-tumor, antileishmanial, anticancer properties. The purpose of this review is to summarize the various naturally occurring chalcone compounds which have been isolated from different plants and to describe the recent...
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Posted by admin on Jan 31, 2020 in |
Capillary Electrophoresis–Mass Spectroscopy (CE-MS) is a hyphenated technique as it combines the advantages of both CE and MS. It provides high-resolution separations with high detection selectivity and sensitivity, which allows detailed characterization of many biomolecules in a single analysis. CE-MS improves the ability to deal with the analysis of complex biological samples containing trace amounts of analytes. CE coupled MS has become a widely used analytical technique in fields such as proteomics, metabolomics, and genomics. It is also increasingly used in various other fields like environmental science, food analysis, biotechnology and forensic science etc. However, the development of online CE-MS is not without challenges. Understanding of CE, the interface setup, ionization technique and mass detection system is important to tackle problems while coupling capillary electrophoresis to mass spectrometry. In this article, instrumentation details of CE-MS, the technical aspects of CE‐MS interface, applications and the advancements made in recent years are...
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Posted by admin on Jan 31, 2020 in |
The purpose of this review article is to discuss in detail about technology transfer in the pharmaceutical industry. The article highlights the objective, reasons for undergoing technology transfer, factors which affect technology transfer, steps involved in technology transfer process. Clearly explains the technology transfer documentation part this is an attempt to understand the aspects related to technology transfer. The transfer may be said to be successful if the receiving unit and the transferee can effectively utilize the technology for business gain. The success of any particular technology transfer depends upon process understanding or the ability to predict accurately the future performance of a process. Three primary considerations to be addressed during an effective technology transfer are the plan, the persons involved and the process. The technology transfer does not mean one-time actions taken by the transferring party toward the transferred party but means continuous information exchange between both the parties to maintain the product...
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Posted by admin on Jan 31, 2020 in |
Now a day’s control delivery of the drug is easily achieved by Microsponge delivery system. These microsponges are very similar to polymeric porous microspheres. In general microsponges are 5-300 micron in diameter, spherical in shape, large porous surface, tiny in structures. Microsponges generally used in the topical drug delivery system but recently they are used for oral administration of drugs. Microsponges deliver its drug on regular time intervals and also respond to the other stimulations. A microsponge has advantages that they modify the release of the drug enhances the stability and effectively reduces the side effects of the drugs. The main aim of formulation is to achieve desired concentration of the drug in the blood. When these microsponges used topically they prevent the accumulation of the drug in both dermis and epidermis. Microsponges can easily entrap and formulated into pharmaceutical product such as gels, creams, powders, liquids, and suspensions. One of the best features of microsponges is it has self-sterilization property; numerous study has confirmed that microsponges are non-...
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