Posted by admin on Mar 31, 2019 in |
Background: Plants and herbs consumed by humans are the rich sources of phytonutrients compounds synthesized in plants itself. Such bioactive substances are responsible for the plant’s antioxidant and medicinal values. Flavonoids are an essential group of naturally occurring polyphenolic compounds, and its flavan nucleus characterizes it. It is one of the most common classes of compounds available in vegetables, fruits, and plant-derived beverages. Flavonoids are considered as health promoting and disease preventing dietary supplements. It is now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal, cosmetic and other applications. Objectives: The main aim of this present review is to discuss the current trends of research and development on flavonoids, general working mechanisms of flavonoids, functions, and applications of flavonoids, prediction of flavonoids as potential drugs in preventing many chronic diseases and future research directions. Discussion: Their basic structures consist of C6-C3-C6 rings with different substitution patterns to produce a series of subclass compounds such as flavones, flavonols, flavanones, isoflavones, flavanols or catechins and anthocyanins. Many...
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Posted by admin on Mar 31, 2019 in |
Herbal treatment used in healthcare system from ancient time. Plants had been used by all cultures, ethnic group and society throughout history in the whole world. Plants are the potential source of secondary metabolites which have high medicinal value and huge utility in healthcare development. Herbal medicines are now in huge prospects in the developing and developed nation for basic health treatment. It is inexpensive and has minimal side effects. Cleome rutidosperma DC (Family-Cleomaceae) is an annual herbaceous plant, and it is commonly known as Fringed Spider Flower. Cleome rutidosperma is not only a weed, but it is an important medicinal plant, too. This review deals with phytochemical, morphological, taxonomical and other important biological aspects of Cleome rutidosperma. Literature survey indicated that this medicinal plant is available in tropical parts of India has various reported biological activities like analgesic, anti-pyretic, anti-inflammatory, locomotory effect, wound healing property, anti-microbial, anti-oxidant, anti-convulsant, anti-diabetic, diuretic and laxative activity etc. The review was done to find out morphological, physicochemical and phytochemical screening of Cleome...
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Posted by admin on Mar 31, 2019 in |
Heterocyclic chemistry plays a very most important role in medicinal chemistry as well as in organic chemistry. Most of the drug molecule formed and possesses therapeutic activity due to the heterocyclic scaffold. A slight change in heterocyclic moiety leads to the major therapeutic change in the drug molecule. Benzothiazole can serve as a unique and versatile moiety for experimental drug design. Benzothiazole and its derivatives are the essential chemical compounds with tremendous application in research area especially in synthetic as well as in pharmaceutical chemistry because of its potent and significant pharmacological activities. As we know that benzothiazole is a combination of two rings six-membered and five-membered and it is also known that both rings are responsible for the therapeutic activity. The main objective of our study is to find what changes lead to a better corrective benzothiazole shift moiety. A well-known approach to design new drug-like molecules, which allows achieving new pharmacological profile, action, toxicity lowering, is the development of a combination of 2- aminobenzothiazoles with another heterocyclic...
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Posted by admin on Mar 31, 2019 in |
About 5-10% of individuals with the condition of prediabetes or intermediate hyperglycemia develop diabetes annually. Prediabetes can revert to normal glycaemic state as well. Reversion to normal glucose, even when transient, is associated with a significant 56% reduced risk of future diabetes independent of previous treatment. Prediabetes is associated with many microvascular as well as macro-vascular complications. Micro-vascular complications include retinopathy, neuropathy, and micro-albuminuria while another complication like heart disease, stroke, and peripheral vascular diseases comes under the macrovascular category. These complications are directly proportional to the succession of hyperglycemia in prediabetes. Detection of the condition prediabetes / intermediate hyperglycemia is a fundamental strategy to keep people from transitioning to diabetes. Lifestyle modification is the mainstay for the management of intermediate hyperglycemia as per various research conducted on the same. The benefit of lifestyle modification with or without pharmacotherapy to prevent or delay the progression of diabetes in patients with prediabetes. When lifestyle modification is ineffective, pharmacologic treatment should be considered although there are no approved pharmacologic treatments for...
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Posted by admin on Mar 31, 2019 in |
Stability of pharmaceuticals is defined as the ability to retain the quality, purity, Identity, and safety throughout the shelf life of products. It is of main concern because drug substance and products lose its Potency and quality after the time passes, due to change in environmental conditions such as temperature, light, and humidity. It is essential that quality of drugs should maintain throw out the life cycle of drug products for their safe and effective use. The need for constant monitoring of the drug substance and product for their quality and purity has the origin of the development of various stability testing methods. Stability testing now becomes a regulatory requirement for filing NDA and ANDA to USFDA and various regulatory agencies. Stability indicating methods had originated from advancement in various analytical instrument technologies. Stability indicating methods of drug substance and products have the ability for separation, identification, qualification, and quantification of all impurities associated with drug substance and drug product at any storage Conditions to give the exact concentration...
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