Posted by admin on Jul 31, 2016 in |
The growing impact of infections caused by dermatophytes i.e. Trichophyton, Microsporum and Epidermophyton is not upto the mark in their treatments via conventional methods due to resistance, side effects, and high toxicity. Over prescription and overuse of traditional antifungal agents, high side effects, less eco-friendly nature, high manufacturing costs, high management costs etc., have stimulated the research for alternative natural drugs, such as herbal extract, essential oils and some commercially available compounds. This paper reviews the antidermatophytic activity of various commercially available and conventionally available herbals from different plants and their major role in prevention of prevalent strains dermatophytes. The mode of action of dermatophytes for causing dermatophytosis as well as mode and mechanism of action of various antifungal agents (herbals extracts, oils, suspensions and commercially available compounds) have also proposed. In vitro susceptibility tests and in vivo models used in antidermatophytic assays as well as the mechanism of action of dermatophytes are involved under the perspective of the potential use of herbals as antifungal agents in the clinical...
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Posted by admin on Jun 30, 2016 in |
Microsponge is recent novel technique for control release as well as target specific drug delivery system. Therefore many researchers are attracted towards the microsponge drug delivery system. Microsponge technology has been introduced in topical drug products to increase the controlled release of active drug into the skin in order to reduce entry of drug in blood and maintain drug on skin surface. Microsponge technology offers entrapment of ingredients, improved stability, reduced side effects, increased elegance, and enhanced formulation flexibility. Various studies have shown result that microsponge systems are non-irritating, non-allergenic, nonmutagenic, and non-toxic. This technology is used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens and prescription products. This technology has the best feature that it is self-sterilizing. In this article we focused on method of preparation, characterization (Particle size and its distribution, surface morphology, porosity, density are covered), advantages, disadvantages and application of...
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Posted by admin on Jun 30, 2016 in |
Biomaterials can be thought as the key ingredients in several implants such as those used for joints, sutures, bone plates, and medical devices such as blood tubes, artificial heart, pacemakers, etc. They function by replacing, restoring the injured or destroyed tissues or organs, and thereby help in providing better essence of life of the patients. A biomaterial which is used in making implants should contain some important desirable properties for long term usage in the body without being itself rejected. They are grouped in four different classes as Metals, Polymers, Ceramics, and Composites which can be used singly or in combination with each other to form most of the commercially available medical devices and implants. In this review we have summarized the importance of biocompatibility and the application of biocompatible materials in various fields of sciences and healthcare...
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Posted by admin on Jun 30, 2016 in |
Herbs & its formulations have a long history of use in the treatment of human diseases. Herbal extracts have long been regarded as a source of new and useful pharmaceuticals. According to Cragg’s investigation, approximately 62 % of commercially available drugs have natural product origins. Manjistha, or Rubia Cordifolia to give it its scientific name, is a branched climber with small, greenish white flowers that are arranged in a cluster of round, fleshy, purple fruits. Its roots have a brownish red bark from which a red dye is obtained. This plant grows well in hilly districts, and the root has medicinal values. Manjistha is considered to be one of the most valuable herbs in Ayurveda, the world’s oldest health care system that originated in India. The ancient physician and sage, Charaka has categorized the herb as varnya or that which improves the complexion, jvarahara, or that which reduces fever, and visaghna or that which detoxifies. It is also a well known rasayana – a rejuvenative. Another great sage, Sushruta has...
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Posted by admin on Jun 30, 2016 in |
In this review our main focus is on flavonoid groups which are one of the main active constituents found with other active constituents like saponins and polysaccharides, while poisonous groups are nitro-compounds, indolizidine alkaloids and the seleniferous derivatives in Astragalus genus. It is well established fact that flavonoid possess many biological activity such as antiallergic, anti-inflammatory, antitumor, antiviral, antioxidant anticancer including anticarcinogenic and prodifferentiative activities. Many flavonoids, including those which are phytoalexins, provide plants with a defense against viral infections. The estrogenic action of many isoflavones is well known and mixtures of flavonoids are commonly used commercially to reduce capillary fragility. Astragalus root is a very old and well known drug in traditional Chinese medicine and have been used to improve resistance to infections and to aid in immunological disorders and viral infections, and also used as hepatoprotective, heart tonic, nephritis and diabetes. This review reports all flavonoids isolated till date which is nearly about 131 from 60 species of Astragalus genus; these flavonoid are further characterized and classified...
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