Posted by admin on Jan 31, 2016 in |
Fluoroquinolones are the most commonly prescribed synthetic antibacterial agents having improved pharmacokinetic properties and broad spectrum of activity. Due to their broad clinical activity they are the most promising drug for antibacterial chemotherapy. The current study focused on the application of similar chromatographic system for the analysis of a number of fluoroquinolones from bulk, pharmaceutical formulations and biological matrices. We have also summarized how a single chromatographic system can be used for the quantification of a number of fluoroquinoloes from their respective marketed formulation. A detailed systemic survey of the sample preparation techniques, the chromatographic conditions and detection of the respective fluoroquinolones has been presented in this study. In the course of this discussion the advantages and applicability of the high performance liquid chromatographic techniques are also...
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Posted by admin on Jan 31, 2016 in |
The abnormal growth of White Blood Cell in the bloods and bone marrow is called as Leukaemia. Leukaemia is the 11th most common cancer worldwide. Leukaemia is not a new disease for Ayurveda, which is mentioned under the heading of Raktarbud respectively. The mutations of any carcinogens are the first causative factor of abnormal growth of cancerous cell including Leukaemia. Accordingly to Ayurveda mithya aahar-vihar is a cause of Rakta Arbud. There are so many carcinogenic agent like Benzene and Pesticide are found in diet, which cause Leukaemia. Anaemia and bleeding tendency along with its complication, Splenomegaly, Hepatomegaly these are some clinical features of Rakta Arbud mentioned in Ayurveda, which is similar to Leukaemia. Trividhparikshan mentioned in Ayurveda a unique method which will help to diagnose the patients of any disease including Leukaemia. Though there is, no basic line of treatment of Leukaemia has found in Ayurveda. Some Raktarbudnashak herbs like Lochnera rosea, Semecarpusana cardium, Urginea indica, podophyllum hexeandrum and Commiphora mukul has mentioned. Certain poly herbal and herbomineral...
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Posted by admin on Jan 31, 2016 in |
Cancer vaccines, a unique approach to cancer therapy are the propitious tools in the hands of the clinical oncologist. Immunization with these specific cancer vaccines put forth an antitumor effect by captivating the host immune response, and has immense prospective for avoiding the inherent drug resistance that confines typical cancer management. Strategies to attain affirmative clinical consequences are entrusted better with the combination of these cancer vaccines with the most effectual immunotherapy agents. Advantages recline as they have exquisite specificity, low toxicity, and the prospective for a robust treatment outcome due to immunologic memory. A handful of propitious prophylactic vaccines are found to be more flourishing in cancer deterrence, still the progress of effective cancer vaccines demand for continued efforts, thoughtful clinical trials, and scientific progress for effective and long-term specific cancer...
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Posted by admin on Jan 31, 2016 in |
The plant Alstonia scholaris has been used in different system of traditional medicine for the treatment of diseases. The extract of the plant showed pharmacological activities ranging from anti-malarial to anticancer properties. Alstonia scholaris is such plant who have medicinal activity against many of the ailments. In recent times, there is an upsurge of interest and focus on the importance of medicinal plants and traditional health systems in solving the health care problems of the world. In India, the bark of Alstonia scholaris is used solely for medicinal purposes, ranging from malaria and epilepsy to skin conditions and asthma. In Ayurveda, it is used as a bitter and as an astringent herb for treating skin disorders, malarial fever, urticaria, chronic dysentery, diarrhea, in snake bite. The Milky juice of the tree is applied to ulcers. An ethanol extract of the bark of Alstonia scholaris enhanced the anticancer activity of berberine in the carcinoma-bearing mice. This extract also showed cytotoxic activity. It contains echitamine and loganin as major compounds and could...
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Posted by admin on Jan 31, 2016 in |
Fusion of a pyrone ring with a benzene nucleus gives rise to a class of heterocyclic compounds called Benzopyrones, of which two distinct types are recognized: (1) benzo-α-pyrone commomly called coumarins and (2) benzo-ϒ-pyrone called chromones or flavanoids, latter differing from former only in the position of the carbonyl group in heterocyclic system. Coumarins have attracted considerable attention of medicinal chemists and pharmacologists in recent years as they been demonstrated to bear various pharmacological activities like anti microbial, anti oxidant, anti inflammatory and analgesic, anti cancer, ulcerogenic, anti malarial, antihyperlipidemic, tyrosinase inhibitor, anti convulsant, anti-parkinsonian, antihepatitis, anticoagulant, cholinesterase inhibitor, vasorelaxant. This review focus on therapeutic importance of coumarins along with various methods of...
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