Posted by admin on Oct 31, 2016 in |
The Process validation involves a series of activities over the lifecycle of the product and process. The FDA guidance described three stages of process validation which includes Process Design, Process Qualification, and Continued Process Verification (CPV). The CPV stage is a never ending approach that continues throughout the entire commercial lifecycle of the product. CPV is dependent on compliance with GMP principles and ensures that manufacturing process remains in a state of control. Establishment of Critical process parameters (CPP) and assessment of Critical quality attributes (CQA) of a product ensures robust manufacturing process and thereby improves productivity and desired quality. The product stability program, change control process & annual product review process serves as key drivers for monitoring process stability. Process analytical technology (PAT) applications such as near infra red spectroscopy, raman spectroscopy & multivariate statistical process control can be viewed as enablers for CPV. The primary goal of PAT is to reduce process variabilities that may impact CQA’s of a product. Continued Process verification is an effective quality...
Read More
Posted by admin on Oct 31, 2016 in |
Zika virus is transmitted to people through aedes mosquito bites. People with Zika virus disease usually have symptoms of mild fever, exanthema (skin rash), joint pain and conjunctivitis that normally last for 2-7 days. There is no specific treatment or vaccine currently available. The best form of prevention is protection against mosquito bites. The virus is known to circulate in Africa, the Americas, Asia and the Pacific. The present paper deals with various modes of transmission, symptoms, diagnosis and preventive measures. A brief discussion about the role of various departments for control and prevention of zika virus. The available means for treatment of zika virus were also...
Read More
Posted by admin on Oct 31, 2016 in |
The rhizosphere represents the thin layer of soil surrounding plant roots and the soil occupied by the roots, supports large active groups of microorganisms. The vast organic compounds (amino acids, sugars etc.) secreted by plant roots in the rhizosphere provide a food source for microorganisms increasing microbial biomass and their activity in the rhizosphere. Antibiotics are antimicrobial compounds produced by living microorganism as secondary metabolites. These compounds are used therapeutically and sometimes prophylactically in the control of infectious diseases. The isolation of antibiotics from microorganisms is relatively easy as compared to chemical synthesis of antimicrobial agents. The isolation of antibiotics from microorganisms improved the discovery of novel antibiotics that could act as better chemotherapeutic agents. With the increased population pressure, costs and side effects and the development of resistance of pathogens to drugs for infectious diseases, there is an urgent need to explore microbes for development of new antimicrobial metabolites. As microorganisms grow in unique and extreme habitats, they may have the capability to produce unique and unusual metabolites....
Read More
Posted by admin on Sep 30, 2016 in |
Stroke remains world’s second leading cause of mortality; and globally most frequent cause of long-lasting disabilities. The ischaemic pathophysiologic cascade leading to neuronal damage consists of peri-infarct depolarization, excitotoxicity, inflammation, oxidative stress, and apoptosis. Despite plethora of experimental evidences and advancement into the development of treatments, clinical treatment of acute stroke still remains challenging. Neuro-protective agents, as novel therapeutic strategy confer neuro-protection by targeting the pathophysiologic mechanism of stroke. The aim of this review is discussion of summary of the literature on stroke pathophysiology, current preclinical research findings of neuroprotective agents in stroke and possible factors that were responsible for the failure of these agents to translate in human stroke...
Read More
Posted by admin on Sep 30, 2016 in |
Flavonoids are the natural compound widely distributed in plant kingdom, it is responsible for the various colors exhibited by bark, leaves, flowers, fruits and seeds of plants. They are the secondary metabolites of plant with significant antioxidant properties. Flavonoids have antioxidant, sedative, antidepressant, anticonvulsant, anti-proliferative, anti-inflammatory, anti-microbial, anticancer, cardioprotective, antihypertensive, antiulcerogenic, antidiabetic and hepatoprotective activity. Many researchers have revealed that the above mentioned pharmacological actions are mainly due to its antioxidant property. Flavonoids have effect on mammalian enzymes like protein kinases, alpha-glucosidase and aldose reductase, thereby regulate multiple cellular signaling pathway that were altered during disease conditions. Various researches on flavonoids are in progress due to its versatile health benefits. En number of flavonoids are available in the market as pharmaceutical products because of its cost effective bulk production and health benefits. The present review is focused on the classification, metabolism, pharmacological and biological actions and flavonoid supplement available in...
Read More
