Posted by admin on Jan 31, 2016 in |
Cancer vaccines, a unique approach to cancer therapy are the propitious tools in the hands of the clinical oncologist. Immunization with these specific cancer vaccines put forth an antitumor effect by captivating the host immune response, and has immense prospective for avoiding the inherent drug resistance that confines typical cancer management. Strategies to attain affirmative clinical consequences are entrusted better with the combination of these cancer vaccines with the most effectual immunotherapy agents. Advantages recline as they have exquisite specificity, low toxicity, and the prospective for a robust treatment outcome due to immunologic memory. A handful of propitious prophylactic vaccines are found to be more flourishing in cancer deterrence, still the progress of effective cancer vaccines demand for continued efforts, thoughtful clinical trials, and scientific progress for effective and long-term specific cancer...
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Posted by admin on Jan 31, 2016 in |
The plant Alstonia scholaris has been used in different system of traditional medicine for the treatment of diseases. The extract of the plant showed pharmacological activities ranging from anti-malarial to anticancer properties. Alstonia scholaris is such plant who have medicinal activity against many of the ailments. In recent times, there is an upsurge of interest and focus on the importance of medicinal plants and traditional health systems in solving the health care problems of the world. In India, the bark of Alstonia scholaris is used solely for medicinal purposes, ranging from malaria and epilepsy to skin conditions and asthma. In Ayurveda, it is used as a bitter and as an astringent herb for treating skin disorders, malarial fever, urticaria, chronic dysentery, diarrhea, in snake bite. The Milky juice of the tree is applied to ulcers. An ethanol extract of the bark of Alstonia scholaris enhanced the anticancer activity of berberine in the carcinoma-bearing mice. This extract also showed cytotoxic activity. It contains echitamine and loganin as major compounds and could...
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Posted by admin on Jan 31, 2016 in |
Fusion of a pyrone ring with a benzene nucleus gives rise to a class of heterocyclic compounds called Benzopyrones, of which two distinct types are recognized: (1) benzo-α-pyrone commomly called coumarins and (2) benzo-ϒ-pyrone called chromones or flavanoids, latter differing from former only in the position of the carbonyl group in heterocyclic system. Coumarins have attracted considerable attention of medicinal chemists and pharmacologists in recent years as they been demonstrated to bear various pharmacological activities like anti microbial, anti oxidant, anti inflammatory and analgesic, anti cancer, ulcerogenic, anti malarial, antihyperlipidemic, tyrosinase inhibitor, anti convulsant, anti-parkinsonian, antihepatitis, anticoagulant, cholinesterase inhibitor, vasorelaxant. This review focus on therapeutic importance of coumarins along with various methods of...
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Posted by admin on Jan 31, 2016 in |
Aim: This article focuses on the current review of world-wide medicinal plants studied for their phytochemical investigations, various biological activities and clinical studies in relation to their use for treatment of Sickle cell disease. Method: All relevant literature databases were searched up to 18 September 2014. The search terms were plant, herb, herbal therapy, phytotherapy, sickle cell anemia and antisickling agent. All of the human, animal, in vitro studies, and reviews were included. Antisickling agent, antioxidant, and ethnopharmacological effects were the key outcomes. Results: In vitro and in vivo studies in various herbs revealed that anthraquinones, anthocaynin, amino acids, caricapinoside, p-hydroxy benzoic acid etc. are the potent herbal constituents responsible for antisickling activity in sickle cell anemia patients and these herbal constituents can be further researched for development of a much safer and affordable medicine in future. Conclusion: This extensive literature review indicated the presence of large number of medicinal plants and their phytochemical constituents that can be of great interest for further research in search of the therapeutically...
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Posted by admin on Jan 31, 2016 in |
Drug release from novel drug delivery systems are desired to be controlled at target site in effective concentration for required therapeutic action with predictable plasma concentrations, unlike conventional ones, thereby reducing the dose, dosage frequency, toxic adverse effects, reduction of blood level fluctuations, improved patient compliance and minimization of drug accumulation. As this can be achieved by the phenomenon called osmosis, osmotic pump drug delivery systems are proved as one of the most promising oral drug delivery systems in the recent times. They are tablets coated with semipermeable membrane which causes pores in water and desired drug release occurs. Drug delivery from this system is not influenced by the different physiological factors within the gut lumen and the release characteristics can be predicted easily from the known properties of the drug and the dosage form. In the present review, a summary of the collected information on the osmotic drug delivery system has been discussed in...
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