Posted by admin on Jul 1, 2013 in |
Multiparticulate drug delivery systems like pellets, granules, micro particles, minitablets etc., prove to be promising and highly flexible systems with ease of formulating with different drug release kinetics. These multiparticulate dosage forms are essential where drug-excipients or drug-drug physicochemical interactions are possible in a single-unit formulation. In present times, pelletization technologies are gaining much attention as they represent an efficient pathway for manufacture of oral drug delivery systems. Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small, free flowing semi-spherical units. Pellets, being multiparticulate systems, are widely used due to the technological as well as therapeutic advantages over single-unit dosage forms. The present review focus on advantages, disadvantages, formation of pellet growth, different pelletization techniques, characterization, marketed pellets products and also outlines recent developments in the pharmaceutical approaches that have been used to prepare pelletized dosage forms with different techniques like Hot Melt Extrusion-Spheronization, Freeze and Cryopelletization, Microtabletting...
Read More
Posted by admin on Jul 1, 2013 in |
Biosimilars are defined as officially approved new version of innovator bio-therapeutic products for which the patent has expired. Biosimilars the ‘generic’ versions of biopharmaceuticals, continue to enter Indian pharmaceutical market, to treat a variety of diseases. Biosimilars available in India include monoclonal antibodies for treating various malignant and immunological disorders, growth factors like erythropoietin and granulocyte colony stimulating factor (G-CSF), human insulins for treating diabetes mellitus etc. In the recent scenario, there is an increasing demand for biological drugs. The development and production of biosimilars are boosted by existing manufacturing technology. Due to no investment in phase I-II of clinical trials, biosimilars are available at cheaper prices than the reference products, so that it has low market risk. The main goal of this review is that the phase I-II trials are typically not required for biosimilar approval unless it is found necessary in special cases. Phase III trials with a minimum of 100 patients are mandatory for establishing bioequivalence. Therefore, the total cost to develop a biosimilar in India...
Read More
Posted by admin on Jul 1, 2013 in |
Nasal drug delivery has occupied an important place in the field of drug delivery technology. Transmucosal nasal delivery is a promising drug delivery option where common drug administration’s (e.g. intravenous, intramuscular, and oral) are inapplicable. This route is also advisable for drugs undergoing extensive first pass effect. The physiology of the nose presents obstacles, but offers a promising route for non-invasive systemic delivery of numerous therapies and debatably drug delivery route to the brain. Nasal route is easily accessible for self-administration without the help of health professionals and no needle stick hazards are associated with nasal administration. To overcome these problems in nasal drug delivery, deep understanding and study of the various factors affecting nasal delivery is muust. Thus present review focuses on various aspects of nasal drug delivery with special emphasis on various formulations available, obstacles, advancement and future prospects in nasal drug...
Read More
Posted by admin on Jul 1, 2013 in |
Candidiasis or moniliasis is more common among the critically ill patients in Intensive Care Unit and in highly immunocompromised patients. This mini review explains the various risk factors for their acquirement and the various treatment options which were used in the past and the current new approaches used in the treatment of candidiasis in the different clinical...
Read More
Posted by admin on Jul 1, 2013 in |
In recent decades, a variety of pharmaceutical research has been conducted to develop new dosage forms. Fast dissolving tablets are one of the fruitful results of these researches. Fast dissolving tablets disintegrate and/or dissolve rapidly in the saliva without chewing and additional water. Mouth dissolving tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and travelling and may not have access to water. This review includes advantages, disadvantages, desired characteristics and various methods used for formulation of fast dissolving...
Read More
