Posted by admin on Sep 1, 2012 in |
This article reviews, connected the gap between the folkloric use of Solanum nigrum and the results of evidence based experiments. Although Solanum nigrum is a rich source of one of plants most dreaded toxins solanine, it has appreciably monstrated its potential as a reservoir of antioxidants having hepatoprotective, anti-tumor, cytostatic, anti-convulsant, anti-ulcerogenic and anti-inflammatory.effects. The review encompasses in-vitro, in vivo and clinical studies done on Solanum nigrum, while examining.whether or not correct scientific measures have been taken in generating experimental evidences for its traditional uses. This review would afford research scientist to know how much is known and what is left undone in the investigation of Solanum nigrum. The compounds considered in this revieware flavonoids and other phenolics, alkaloids (especially indole terpenoid and purine alkaloids), essential oils and other terpenoids, cannabinoids, lucosinolates and isothiocyanates, and compounds having human hormone activity. The review concludes with a discussion of the possible evolutionary mechanisms that have led to the evolution of UV-B regulation of secondary metabolite accumulation. Many Ayurveda philosophers and healers...
Read More
Posted by admin on Sep 1, 2012 in |
Heterocyclic compounds are of very much interest in our daily life. Heterocyclic compounds have one or more hetero atoms in their structure. They may be cyclic or non cyclic in nature. Heterocyclic compunds have a wide range of application. They are predominantly used as pharmaceuticals, as agrochemicals and as veterinary products. They also find applications as sanitizers, developers, antioxidants, as corrosion inhibitors, as copolymers, dye stuff. They are used as vehicles in the synthesis of other organic compunds. Some of the natural products e.g. antibiotics such as penicillin’s, cephalosporin; alkaloids such as vinblastine, morphine, reserpine etc. have heterocyclic...
Read More
Posted by admin on Sep 1, 2012 in |
The ophthalmic in-situ gels now days proved an palpable sustained drug delivery in various eye diseases. The formulation of in-situ gels for eye which carries the advantages like easy for administration, reduces frequency of dose and improves patient compliance. The formation of in-situ gels depends on phase transition system or sol-gel transition system. The formulation approaches like temperature intonation, pH change and presence of ions from which the drug gets released in a sustained and controlled manner are utilised for in-situ gels. Various polymers that are used for the formulation of in-situ gels include chitosan, Pluronic F-127, poly-caprolactone, gellan gum, alginic acid, xyloglucan, pectin...
Read More
Posted by admin on Sep 1, 2012 in |
The drug delivery technology landscape has become highly competitive and rapidly evolving. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Conventional topical formulations are intended to work on the surface of the skin. Normally, upon application such formulations release their active ingredients and producing a highly concentrated layer of active ingredient that is quickly absorbed. Therefore, need exists for a system to increase the amount of time that an active ingredient is present either on skin surface as well as within the epidermis, at the same time, minimizing its transdermal penetration in the body. In recent times, microsponge delivery system (MDS) has been successively addressed for the controlled release of drugs onto the epidermis with assurance that the drug remains chiefly localized and does not enter the systemic circulation in major amounts. Drug loaded microsponge consist of microporous beads, typically 10-25 μm in diameter that possess a versatility to entrap wide range of active agents. Microsponge Systems are...
Read More
Posted by admin on Sep 1, 2012 in |
The gold standard in pharmaceutical industry is the oral delivery because it is the easiest, safest, economical and convenient method for the drug delivery. Mouth dissolving tablets have becomes the most demanding application during last decades and in the pharmaceutical industry this field has become a rapidly area. Mouth dissolving tablets during insertion in the mouth should have to dissolve or disintegrate in the mouth within 15sec to 3 minutes without the help or need of any drinking agent like water. These mouth dissolving tablets can be given anytime, anywhere to anyone who needs this without the presence of water and these will show the effective action in few...
Read More
