Posted by admin on Aug 1, 2012 in |
The oral delivery of lipophilic drugs presents a major challenge because of the low aqueous solubility and less bioavailability. Self-micro emulsifying drug delivery systems (SMEDDSs) have gained exposure for their ability to increase solubility and bioavailability. SMEDDS, which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. SMEDDS can be orally administered in soft or hard gelatin capsules and form fine relatively stable oil-in-water (o/w) emulsions upon aqueous dilution owing to the gentle agitation of the gastrointestinal fluids. The efficiency of oral absorption of the drug compound from the SMEDDS depends on many formulation-related parameters, such as surfactant concentration, oil/surfactant ratio, polarity of the emulsion, droplet size and charge, all of which in essence determine the self-emulsification ability. Thus, only very specific pharmaceutical excipient combinations will lead to efficient self-microemulsifying systems. The fact that almost 40% of the new drug compounds are hydrophobic in nature implies that studies with...
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Posted by admin on Aug 1, 2012 in |
Nyctanthes arbor-tristis Linn. (NAT) is well known Indian medicinal plant. The plant is used in Ayurveda for various pharmacological actions such as anti-arthritic, antispasmodic, antibacterial, anti-inflammatory, immunostimulant, antidiabetic, hepatoprotective, antiarthritic, antioxidant, antimicrobial, antihelmintic, antileishmanial, antiviral, CNS depressant. The present review discusses pharmacology of the herb, its pre-clinical and clinical studies, safety and herbal drug interaction which is a need of the...
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Posted by admin on Aug 1, 2012 in |
Vitex negundo Linn. belong to family Verbenaceae. It is an important medicinal plant.Literaturesurvey of V. negundo revealed the presence of different classes of natural products including essential oil,triterpenes, diterpenes, sesquiterpenes, lignan, flavonoids,flavones glycosides, iridoid glycosides, and stilbene derivative. The plant is traditionally reported for its use for the treatment of cough, asthma, fever, eye disease, inflammation, intestinal worms, skin diseases, nervous disorders, leprosy and rheumatism. Roots are tonic, anodyne, febrifuge, bechic, expectorant and diuretic. This review is short review of last two years reporting the natural products isolated and biological potential of Vitex negundo...
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Posted by admin on Aug 1, 2012 in |
From the dawn of civilization, medicinal plants are known to be part of human society to combat diseases. In recent times, focus on plant research has increased all over the world and various evidences have been collected to show immense potential of medicinal plants used in various traditional systems. India officially recognizes over 3000 plants for their medicinal value. It is generally estimated that over 6000 plants in India are in use in traditional, folk and herbal medicine. This paper aims to provide a comprehensive review on the phytochemical and pharmacological aspects of Curculigo orchioides, Amaryllidaceae also known as “Golden eye grass”. It possesses a vast ethnomedical history and represents a phytochemical reservoir of heuristic medicinal value. It is one of the oldest oriental medicines mentioned in Ayurveda as potential remedy for various ailments. The rhizome is rich in Curculigoside, other glycosides, steroids, flavonoids and also contains various polyphenolic compounds. Many pharmacological studies have demonstrated the ability of the rhizome shows antioxidant, anti inflammatory, spermatogenic, aphrodisiac, immunostimulant, hepatoprotective, antiasthamatic,...
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Posted by admin on Aug 1, 2012 in |
Transdermal drug delivery system (TDDS) is topically administered dosage form in the form of patches which deliver drugs for systemic effects at a predetermined and controlled rate. It works very simply in which drug is applied inside the patch and it is worn on skin for long period of time. By this constant concentration of drug remain in blood for long time. Polymer matrix, drug, permeation enhancers are the main components of TDDS; Polymers include gelatine, gum Arabic, methyl cellulose, starch, shellac, etc. (as a natural) to synthetic ones (polyethylene, polystyrene, acetyl co-polymer, polyvinyl chloride, polyamide, polyvinyl acetate, etc.) TDDS are of many types varying from single layer drug in adhesive to multi layer drug in adhesive and others are reservoir and the matrix systems. The market value of TDDS products are increasing with rapid rate, more than 35 products have now been approved for sale in US, and approximately 16 active ingredients are approved globally for use as a TDDS. Transdermal drug delivery is a recent technology which...
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