Posted by admin on Jun 1, 2011 in |
Recently, heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. The small and simple benzothiazole nucleus possesses numerous biological properties like – antitumor, antimicrobial, anti-inflammatory, anticonvulsant, and antidiabetic activities. These activities are also possessed by its substituted derivatives as well. The present review focuses on some commonly used easy procedures to synthesize the benzothiazole moiety and its derivatives, which comprise of different biological...
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Posted by admin on Jun 1, 2011 in |
Buccal drug delivery has gained significant attention and momentum since it offers remarkable advantages. Over past few decades, buccal route for systemic drug delivery using mucoadhesive polymers to significantly improve the performance of many drugs has been of profound interest. This review article is an overview of buccal drug delivery systems encompassing a review of oral mucosa, formulation considerations for buccal drug delivery system, theories and mechanism of mucoadhesion, different mucoadhesive formulations for buccal drug delivery and active ingredients delivered via the buccal route. Additionally, commercial technologies and future prospects of this route of drug delivery are discussed....
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Posted by admin on May 1, 2011 in |
The scientist faced many challenges in Ocular drug delivery system due to unique anatomy and physiology of eye. In ocular drug delivery system there are two types of barriers static and dynamic barrier. Static barriers consist of different segment of eye such as cornea, sclera, retina and blood- retinal barriers. In other way dynamic barriers consists choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution. These both barriers affect the bioavailability of drugs. In recent year some new concept of drug delivery such as iontophoresis, liposome bioadhesive gels, ocular insert, contact lenses etc has been developed to overcome problems associated by static and dynamic barriers These formulation based approaches have high capacity to carry maximum concentration of drug at targeted site of...
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Posted by admin on May 1, 2011 in |
Cardiovascular disease remains a leading cause of death in most industrialized countries. Therefore, finding ways to reduce the mortality of cardiovascular disease remains an important public health goal. This review deals with medicinal plants possessing cardioprotective and cardiotonic activity. This review work explains chemical and pharmacological status of various cardioprotective plants including phytoconstituents responsible for cardioprotection, extract employed, dosage, pharmacological screening model and mechanism involved in cardioprotection. This review work definitely potentiates the work on cardioprotective plants....
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Posted by admin on May 1, 2011 in |
Stress undoubtedly has become an integral part of human life. Stressful conditions have a derogative effect on normal physiological functions leading to a variety of disease states. Many of the most prevalent diseases of the modern era like hypertension, diabetes, behavioral disorders, etc. have been implicated as one of the many ill-effects of chronic stress. Experimental models are required to better understand the progression of the disease and elaborate new therapy. Therefore a need to develop animal models of stress has always been realized. An ideal model should be able to reproduce each of the aspects of stress response and should be able to mimic the natural progression of the disease. Unfortunately different models of stress that have been used are able to evaluate some of the many biochemical or physiological parameters that get altered as a response to stress but are unable to fully mimic the patho-physiological changes caused by...
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