Posted by admin on May 1, 2010 in |
The chemistry of pyrimidine is a blossoming field. Numerous method for the synthesis of pyrimidine and also their diverse reactions offer enormous scope in the filed of medicinal chemistry. The utility of pyrimidines as synthon for various biologically active compounds has given impetus to these studies. The review article aims to review the work reported and the chemistry and biological activities of pyrimidines during past year....
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Posted by admin on May 1, 2010 in |
In recent years, development in science and technology has brought about significant changes to world in which we live. One such change has been the introduction of cosmetic surgery into mainstream life, having growth from being the presence of rich and famous to being an increasingly accepted option for ordinary people. Cosmetic surgery is a special branch of surgery that deals with the medical correction of person’s form and structure. Peoples have a tendency to confuse plastic surgery with cosmetic surgery, but there is actually a difference between the two. Cosmetic surgery is in fact a sub-specialty of plastic surgery and refers to surgery which is carried out purely for cosmetic purposes. The most common procedures for cosmetic surgery are discussed in the following articles. In recent years, people worldwide seem to be increasingly aware of their body image and more people are in search of the perfect body. So cosmetic surgery offers solutions to people’s problems if they feel that their own body falls short of perfection, and...
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Posted by admin on Apr 1, 2010 in |
For cancer therapy, microtubule network is an attractive cellular target. Main component of cell cycle is mitotic stage, particularly when the mitotic spindle separates the replicated chromosomes. The rapid microtubule dynamics also play a critical role for activities of the bipolar spindle. Microtubule targeting drugs act at binding site either by destabilizing or hyper-stabilizing microtubules. It results mitotic arrest at the prometaphase or metaphase to anaphase transition, then it leads to subsequent apoptotic cell death. Taxanes and Vinca alkaloids have been validated by the successful use for a wide variety of human cancer. Clinical development of colchicines for cancer therapy has not been successful till now because they produce toxic effect in normal tissues. Semi-synthetic analogue of taxane, docetaxal is more potent than paclitaxel against cancer cell proliferation. It is now used for the treatment of breast, prostate and non small cell lung cancer. Successful use of paclitaxel and docetaxel in cancer therapy has inspired the new microtubule targeting agents that bind to taxane site, like Epothilones, discodermolide, eleuthelobin,...
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Posted by admin on Apr 1, 2010 in |
Dendrimers are a new class of polymeric materials. They are highly branched, monodisperse macromolecules. Structural Advantages allow dendrimers to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry. As a result of their unique behaviour dendrimers are suitable for a wide range of biomedical and industrial applications. The paper gives a brief review of dendrimers’ physico-chemical properties and their possible use in various areas of research, technology and...
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Posted by admin on Apr 1, 2010 in |
More than 50% of pharmaceutical products are orally administered for several Reasons and undesirable taste is one of the important formulation problems that is Encountered with such oral products. Taste of a pharmaceutical product is an important parameter governing compliance. Hence taste masking of oral Pharmaceuticals has become important tool to improve patient compliance and the Quality of treatment especially in paediatrics. Different methods have been suggested for Masking of taste of bitter drugs, which includes, coating of drug particles with inert agents, taste masking by formation of inclusion complexes, molecular complexes of drug with other chemicals, solid dispersion system, microencapsulation, multiple emulsions, using liposome’s, Prodrugs and mass extrusion method but ion exchange resin is one of most extensively Used method to overcome this problem. Ion-exchange resins (IER) have received considerable attention from pharmaceutical scientists because of their versatile properties as drug-delivery vehicles. In the past few years, IER have been extensively studied in the development of novel drug-delivery systems (DDSs) and other biomedical applications. Also Recently the New...
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