Posted by admin on Mar 1, 2011 in |
Many drugs exist in crystalline solid form due to reasons of stability and ease of handling during the various stages of drug development. Crystalline solids can exist in the form of polymorphs, solvates or hydrates. Phase transitions such as polymorph inter-conversion, formation of hydrates, desolvation of solvates, and conversion of the crystalline to amorphous form may occur during various pharmaceutical processes. This could change the dissolution rate and transport characteristics of the drug. The current focus of research in the area is to understand the origins of polymorphism at the molecular level, and to predict and prepare the most stable polymorph of the drug. The aim of this review is to understand the recent development in the area of solid state crystallinity, amorphous state and to address the current challenges faced by pharmaceutical formulation, process development scientists and to anticipate future...
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Posted by admin on Feb 1, 2011 in |
In the present article attempt has been made to explain the basic ideas and the significance of Thin layer Chromatography (TLC) in different analytical methods. As TLC is less time consuming, low cost, and can be performed with less complicated technique it has a wide application in pharmaceutical analysis. If performed precisely 32 amino acids can be separated by TLC. Also it has a wide application in identifying impurities in a compound. It can be used as a preliminary analytical method prior to HPLC. The concept of TLC is simple and samples usually require only minimal pretreatment. TLC can be used to monitor the progress of a reaction, identify compounds present in a given substance. TLC is also used to separate the identical compounds in a mixture. Many standard methods in industrial chemistry, environmental toxicology, food chemistry, water, inorganic and pesticide analysis, dye purity, cosmetics, plant materials, and herbal analysis rely upon TLC as the preferred approach....
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Posted by admin on Feb 1, 2011 in |
Ayurveda is time-tested science of treating disease with natural things like plant, animals and minerals. It remains one of the most ancient and yet living traditions practised widely in India, Sri Lanka and other countries and has a sound philosophical and experiential basis. Plumbago zeylanica is commonly known as white chitraka, belongs to family plumbaginaceae. It is distributed as a weed throughout the tropical and subtropical countries of the world. It is a perennial sub-scandent shrub, grows throughout India, especially in Bengal, Uttar Pradesh, South India and Sri Lanka, in moist places. Traditionally it is used as a stimulant, digestant, expectorant, laxative, abortifacient and in the treatment of muscular pain and rheumatic disease. So the objective of the present review is to highlight the phytochemical and pharmacological information of this...
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Posted by admin on Feb 1, 2011 in |
The main objective of the present study was to conduct an in depth study of the advances made in the therapy with music and the developments made in its applications in the health care, using primarily resources of published material in the internet. The current study was mainly aimed at understanding music therapy from the perspective of its applications in the field of medicine as a novel alternative therapy. Music therapy is defined as a holistic and utilitarian approach towards treatment by applying music or specialized sounds with a view to cure disease or disease conditions in a completely non invasive manner. Apart from the advantage that it does not have any side effects, it also have an added advantage that it is a completely patient friendly therapy, that is the therapy can be conducted in the comfort zone of the patient. It is the psychological and emotional approach towards treatment that makes this therapy stands out from the conventional therapies. The main objective of music therapy is to...
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Posted by admin on Feb 1, 2011 in |
Epilepsy is a neurological disorder characterized by excessive electrical discharge in brain, which causes seizures. The therapeutic strategy in countering epilepsy involves reducing neuronal excitability through different mechanistic pathway. Most therapeutics currently used in the treatment of epilepsy is either directed towards blocking voltage-gated sodium and calcium channels or potentiating gamma amino butyric acid (GABA)-mediated neurotransmission, with little focus on voltage gated potassium ion channels, despite these channels having a major role in the control of all aspects of neuronal excitability. It is reported that functional impairment of potential channel, either by mutation or inhibition, result in...
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