Posted by admin on Jun 30, 2023 in |
A study has reviewed three medicinal plants from India that have been traditionally used for treating and preventing diseases, including cancer. These plants, namely Withania somnifera (L.) Duna L, Andrographis paniculata (Burm.f.) Wall, and Glycyrrhiza glabra L., possess anti-cancer and anti-tumorous properties. They contain various bio-active constituents and secondary metabolites, such as Withanolides, Withaferins-A, D, Withanone, Withanosides, steroidal lactones, Adriamycin, and 5-fluorouracil in Withania somnifera (L.) Dunal. Andrographis paniculata (Burm.f.) wall contains Andrographolide, β-Sitosterol, Stigma Sterol, Chlorophylla, 5-2-dihydroxy-7,8-dimethoxy-flavone, β-Sitosteryl fatty acid ester, lupeol, and Triacylglycerols. Glycyrrhiza glabra (L.) contains Glycyrrhezic acid, 18β-Glycyrrhetic acid, Glycyrrhizin, Anethole,(3% to total volatile), Iso-flavone Glabreneonl, Iso-flavone glaberidin, Licochalcone-A, and licoagrochalcone. These plants have shown promising results in preventing and inhibiting the growth of cancer cells and tumours in both in-vitro and in-vivo studies. The study highlights the ethnobotanical, pharmacological, and biological activities of these plants and emphasizes their potential for novel drug discovery, pharmacopoeial standardization, and clinical...
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Posted by admin on Jun 30, 2023 in |
In present days, solid oral drug dosage forms are widely used and the largest part of the entire drug delivery system due to their more, easy preferable route of administration and improved patient convenience nature. Most of the oral drug delivery systems show a distinctive drug release pattern, and the drug concentration is maintained within the limit of the therapeutic range. With technological advancement, pulsatile medication delivery devices are becoming increasingly important and popular for controlled delivery systems based on drug design. It maintains the circadian rhythm of the disease conditions and reduces the side effects of the drug. So, the important action of pulsatile drug delivery systems is used to delivery the drug at right time, site or target, and quantity. The drug release follows the sigmoid al release pattern, characterized by a period of no release (lag time). These systems release or deliver the drug based on the pathophysiological need of the disease at a specific time. So, it improves the therapeutic efficacy, compliance of the patient...
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Posted by admin on May 31, 2023 in |
In Indian and Chinese medicine, the herb Bacopa monnieri, (Neer Brahmi) has long been used to treat a wide range of illnesses. Brahmi offers a wide range of pharmacological advantages, including improving memory in the treatment of schizophrenia and Alzheimer’s disease. The effectiveness of Brahmi in scavenging and illuminating as well as comprehensive analyses based on its pharmacological effects on the thyroid are the focus of the current review. Up until April 2022, PubMed, Scopus, and Google Scholar were searched to find information about the effectiveness of Bacopa monnieri in treating thyroid disorders. The review’s conclusions provide an overview of the information gathered over the preceding five years from various platforms and database libraries. For all calculated data, a number of outcomes were combined into verified constructs to enable direct comparisons. Four papers satisfied the criteria for inclusion in this review. This extensive study provided a summary of Bacopa monnieri’s effectiveness in scavenging free radicals and deciphering thyroid disorders. It’s time to move on to other prevalent problems because...
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Posted by admin on May 31, 2023 in |
Medicinal plants are a huge treasure for mankind and a source of remedy for all illnesses as they are storehouses of bio-actives. The therapeutic efficiency of formulations and medicines depends on using standardized plant extracts, as The World Health Organization emphasized. The present documentation on the medicinal plant Pisonia grandis covers its pharmacological, phytochemical, biological standardization studies and the quantification protocols for the bioactive pinitol and bioactive allantoin earlier reported from this plant. This documentation sheet will aid as a reference for formulating Pisonia grandis-based herbal medicinal...
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Posted by admin on May 31, 2023 in |
Pyrazolines, among the various 5-membered heterocyclic compound derivatives, have drawn attention towards it because of their various pharmacologic activities. They are nitrogenous heterocyclic compounds containing two nitrogens in the adjacent position, which possess considerable biological activity. The synthesis of pyrazolines was initiated after the pioneering work of Fischer and Knoevenagel in the late 19th century. Later, Claisen-Schmidt condensation, and Aldol-condensation, became the most popular methods for the preparation of pyrazolines nowadays. It has been an exciting area of pharmaceutical chemistry to research the biological evaluation of pyrazoline derivatives. The review provides different methods for the synthesis of pyrazolines by Claisen-Schmidt condensation, Aldol-condensation, 1,3-Dipolar Cycloaddition and its biological activities like anti-inflammatory, anti-tubercular, hypotensive, Cannabinoid CB1 Receptor Antagonist activity, anti-viral, etc. It also gives information regarding different possible docking targets and examples in figures. This review article will help explore novel pyrazoline analogues for challenging pathophysiological...
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