Posted by admin on Apr 30, 2023 in |
In recent days, the increasing number of microbes and their increasing resistance power against conventional drugs have led to enormous worldwide mortalities, hence they pose a great threat to human health. The modern era is already going through the threat of COVID-19, also caused by one of those microbes called the virus. In order to get a clear understanding, all the microbes have been classified in certain types. Nowadays, to develop new alternative antimicrobial medicines, scientists must acquire clarity about the responsible functional groups of different conventional drugs with proper mechanistic elucidation on different types of microbes. This information not only clarifies the functionalities and properties responsible for exhibiting antimicrobial effects, but also facilitates the idea of new drug development through proper functional group incorporation or modification. These modifications increase the efficacy of antimicrobial drugs as well as their activity and water solubility. In this review, my focus will majorly be on the four main types of microbes and their possible mechanistic elucidation of commonly used antibiotics and alternative...
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Posted by admin on Apr 30, 2023 in |
Oral controlled release and site-specific drug delivery systems have gained interest in the pharmaceutical industry to improve the treatment of certain critical medications. To overcome physiological barriers, such as short stomach resident lengths and variable gastric emptying periods, the idea of a novel drug delivery mechanism evolved. To improve the bioavailability of drugs with narrow therapeutic windows, delay the onset of drug elimination from the body, and increase patient compliance, one of these novel approaches is the gastroretentive drug delivery system (GRDDS), which is implanted in the upper part of the gastrointestinal tract. This investigation discusses the GRDDS, factors associated with the GRDDS, the advantages and disadvantages of the GRDDS, alternative approaches to the GRDDS, and different polymers used for gastroprotection. A great deal of work is being put into developing several GRDDS types at the moment. Because of this, pharmacotherapies of all types stand to benefit from their growing prominence...
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Posted by admin on Apr 30, 2023 in |
Plants are essential to the survival of every species on Earth. Animal and plant life have a history of mutual consumption since antiquity. Earth’s sole producers are plant is a fact. As researchers learn more about plants, this assumption is being challenged. The Rutaceae family’s citrus species Aegle marmelos (Bael), a well-known medicinal herb, has a lengthy study history. In addition to its useful nutrients, A. marmelos produces a wide range of secondary metabolites, or phytochemicals, during its whole life cycle. Roots, bark, stems, leaves, fruit, and flowers are all used by humans in some way or another obtained from the A. marmelos plant. Various phytochemical substances include various alkaloids, flavonoids, phenols, tannins, coumarins, saponins, carbohydrates, carotenoids, terpenoids, vitamins, and tannins generated by A. marmelos plants. The main phytochemical compounds isolated from A. marmelos plant are aegelenine, fragrine, halfordinol, marmelide, marmelosin, marmesin, marmin, psoralen, umbelliferone, limonene, rutin, skimmianine, lupeol, quercetin, esculetin, scopoletin, auraptene, seselin, etc. These phytochemical compounds obtained from the A. marmelos plant parts are being used since...
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Posted by admin on Apr 30, 2023 in |
Most pharmaceutical drugs create problems during formulation as they are insoluble or poorly soluble in aqueous and non-aqueous mediums. It was proved that reducing the drug particle size increases the drug’s Solubility, Dissolution and Bioavailability. Many conventional techniques may be used, but the desired amount of particle size may not be achieved, and Solubility, Dissolution and Bioavailability still be a problem. Nanotechnology is a promising technique for formulating poorly soluble drugs. Nanotechnology helps us to reduce the drug particle size to submicron level and due to this, drug particle surface area increases which lead to solubilization of the drug. An increase in solubility leads to increased dissolution and Bioavailability of drug which leads to an increase in the drug’s effectiveness. Also, Nanotechnology has many advantages over conventional techniques. One of the most important advantages of Nanotechnology is that particle size can be reduced from 300 nm to 10µ. Nanotechnology helps us formulate insoluble drugs in aqueous and non-aqueous mediums into different dosage forms without using harsh organic solvents for...
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Posted by admin on Apr 30, 2023 in |
The rising burden of cancer worldwide calls for an indispensable treatment result. Herbal drug provides a veritably doable volition to western drug against cancer. This composition reviews the named plant species with active phytochemicals, the animal models used for these studies, and their nonsupervisory aspects. This study is grounded on a scrupulous literature review conducted through the hunt of applicable keywords in databases, Web of Science, Scopus, PubMed, and Google Scholar. Twenty shops were named grounded on defined selection criteria for their potent anticancer composites. The detailed analysis of the exploration studies revealed that plants play a necessary part in fighting different cancers similar as bone, stomach, oral, colon, lung, hepatic, cervical, and blood cancer cell lines. The in-vitro studies showed cancer cell inhibition through DNA damage and activation of apoptosis- converting enzymes by the secondary metabolites in the plant excerpts. Studies that reported in-vivo conditioning of these plants showed remarkable results in the inhibition of cancer in animal models. Further studies should be performed on exploring further plants,...
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