Posted by admin on Feb 28, 2023 in |
The heterocyclic compounds are formed by the hetero atoms (O, S, N, etc.) in the cyclic ring system. These are mainly started from 3- membered to 10- membered heterocyclic rings. The compound containing heterocyclic molecules shows potent activity in various pharmacological targets. Benzothiazole is a fusion of a benzene ring with a 5-membered thiazole ring which is widely used in heterocyclic compounds. The benzothiazole pharmacophore and its derivatives are used for the development of novel drugs and have also shown different pharmacological and biological activities such as anticancer, antibacterial, antifungal, anti-inflammatory, analgesic, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial activities. In previous years, few new benzothiazoles have been shown with different biological responses. In such a manner, this review illuminates the benzothiazole and its substituted product that possesses distinct biological activity. This article discovered a novel benzothiazole-based drug that has shown less toxic and more active...
Read More
Posted by admin on Feb 28, 2023 in |
Phytomedicines from herbal plants are widely used as a home remedy in ancient times to maintain the normal health of human beings. As per World Health Organization (WHO) estimation, nearly 75-80% of the population in the world utilizes medicinal plants for their primary health care. Duranta erecta itself has antioxidant and anti-microbial activities and has been used in Africa and Asia to treat a wide range of diseases. Evaluation of the study is based on the phytochemical profile, anti-microbial and antioxidant activities of D. erecta to ascertain its health benefits in traditional medicine. Plant parts with antimalarial, anti-bacterial, antioxidant, anthelminthic, antifungal, antiparasitic, insecticidal, and cytotoxic activity have been reported to include leaves, fruit, stems, and flowers. Fruit, flowers, leaves, and stems were screened for the presence of phytochemicals such as iridoid glycoside, alkaloids, flavonoids, saponins, terpenes, tannins and sterols, C-alkylated flavonoids beta-sitosterol, naringenin, triterpenes saponins, steroidal glycosides. Plant extracts of D. erecta leaves that have antioxidant activities show potential effects in many conditions initiated by oxidative stress. This review reveals...
Read More
Posted by admin on Jan 31, 2023 in |
Semecarpus anacardium Linn. (Family Anacardiaceae), generally known ‘Ballataka’ or’ Bhilwa’, is a factory well-known for its medicinal value in ayurvedic and siddha system of the drug; it’s also used for non-medicinal purpose like marking of cloth, hair color, etc. since ancient time. Phytochemical analyses of Semecarpus anacardium nut shows that, its nut contains a variety of biologically active composites similar as biflavonoids, phenolic composites, bhilawanols, minerals, vitamins, and amino acids, which shows colorful medicinal parcels. The oleic acid content present in the kernel indicated that it could be used as a good source of salad oil. Traditional healers and croakers use Semecarpus anacardium in their clinical practice. Several trials have proved its anti-atherogenic, anti-inflammatory, antioxidant, antimicrobial, anti-reproductive, CNS stimulant, hypoglycemic, anticarcinogenic and hair growth protagonist conditioning. An exhaustive literature survey was performed on Semecarpus anacardium Linn by using various scientific databases to validate the ethnomedical properties of the plants. The present review of literature has focused on ethnomedicinal, nutritional value, phytochemical components, and pharmacological properties of Semecarpus anacardium...
Read More
Posted by admin on Jan 31, 2023 in |
Herbs have been a surviving unit since we were born on this planet. Currently, they are the most probed topic in the food industry or pharmacotherapy due to their multidimensional approach where one herb targets various diseases and proffers a wide range of health benefits. Moreover, some herbal supplements are merchandised globally, and people are devouring these products blithely to extract additional benefits. But taking any herbal formulation under unsupervised conditions may be subject to herbal toxicity. Hence, providing safe herbal supplements is a daunting challenge for various reasons: availability of unstandardized, contaminated, adulterated, loosely available, and unlabeled products, scanty regulations, herb-herb, and herb-drug interaction, and many others. The present article is enriched with past and most recent literature on processing crude herbs, the necessity of standardization of herbal products, the health benefits of standardized herbal medicines, and the toxicity of herbal formulations. The literature has also discussed a case study linked to herbal products, the importance of the pharmacovigilance system, and the challenges associated with the safety monitoring...
Read More
Posted by admin on Jan 31, 2023 in |
Nanostructured Lipid Carriers (NLCs) is a novel type of drug-delivery system. They are binary system which is stable in a different environment. Nanostructured Lipid Carrier (NLC) comprises a blend of solid and liquid lipids as a core matrix. NLCs have aggravated the incessant impulsion for developing safe and valuable drug delivery systems due to their exceptional physicochemical and biocompatible characteristics. Additional utilization NLCs is crucial because of overcoming barriers enclosed by the technological procedure of lipid-based nanocarriers’ formulation and raised data on the core mechanisms of their transport via numerous routes of administration. NLC it can be easily used as a carrier for drugs via different routes of administration such as oral, parenteral, ocular, and nasal. Nanostructured lipid carriers (NLCs) have been reported to be an alternative system and are considered superior to many other traditional lipid-based nanocarriers such as emulsions, nanoemulsion, liposome, microparticle, and solid lipid nanoparticle (SLNs). It imparts many advantages over SLN’s such as increased solubility and stability, improved permeability and bioavailability, enhanced drug loading capacity,...
Read More
