Posted by admin on Oct 31, 2022 in |
Manuscript aims to furnish glimpse on coating processes (CoPr). The coating is the process of applying coating materials (CoMa) onto the substrate surface (S-S). With time and space dimension of CoPr, that upraised as sugar-coating (S-C) expanded to film-coating (F-C) and specialized one. Lengthy and wearisome processing and skilled operators issues inherited to S-C spring-up F-C and its improvement from non-aqueous F-C to aqueous film-coating (AF-C). Non-aqueous film-coating processes (F-CP) make use of a volatile organic solvent (VOS) while AF-C processes uses aqueous solvent (AS), as a solvent system for coating formulations (C-F). VOS is preferred over AS in F-CP, and momentum for using AS has been accelerating from past few decades. Issues from VOS’s use upraised relating to safety; worker hygiene & safety; toxicity; environmental pollution; etc. These upraised issues intensified, thus, nowadays, AF-C processes are replacing VOS-based F-CP. Later on, finding the novelty of coating and CoPr thru coating of particulates became another dimension of expansion. This involves modification and/or alteration in innate properties of particulates, chemically...
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Posted by admin on Oct 31, 2022 in |
Nanogels (NGs) are advanced and innovative drug delivery systems that play an important role in remarking many issues that are associated with recent and trendy courses of treatment, such as non-specific effects and low stability. NGs could be well-defined as extremely cross-linked hydrogels (nano-sized) ranging from 20-200 nm. NGs are vigorous nanoparticles (NPs) used to deliver active drug complexes for the controlled delivery of drugs. This system is simpler and safer for both hydrophobic and hydrophilic drugs because of their chemical composition and formulations that are unsuitable for different formulations. Drugs are incorporated into NGs for many purposes, like gene targeting, organ targeting, diagnosis, and many more. NGs can be administered through different pulmonary, nasal, transdermal, intra-ocular, oral, and parenteral routes. Frequently, NGs are used to treat cancer, bone regeneration, inflammation, etc. This NGs system is a novel drug delivery system for hydrophobic and hydrophilic drugs. This review mainly focuses on providing general information on NGs, their properties, various classifications, drug targeting methodology, different types of drug delivery systems, evaluation methods and novel applications of NGs in...
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Posted by admin on Oct 31, 2022 in |
A hydrogel with strongly cross-linked hydrophilic polymer chains makes up the majority of nanogels, which are essentially nanoparticles. Several hydrophilic functional groups in hydrophilic polymers enable nanogels to absorb large amounts of water. Incredibly stable, adaptable, and responsive to sensory influences, nanogels have the potential to be a safe and effective medication delivery vehicle for biological products. Peptides, hormones, DNA, vaccines, chemotherapeutic treatments, and a wide range of pharmaceutical goods can all be delivered using these devices. There are several varieties of nanogel-based drug delivery systems, varied techniques of production, processes of drug release, and commercially available formulations. The presentation emphasizes the various types of nanogel based drug delivery systems, preparation methods, drug release mechanisms, marketed preparations, and their various applications in the medical...
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Posted by admin on Oct 31, 2022 in |
Numerous therapeutic and prophylactic interventions are tried being developed and tried for COVID-19, from repurposed drugs, antivirals to immunotherapy including convalescent serum, vaccines and monoclonal antibodies to reduce the global burden of the disease. Vaccine-derived immunity develops over time and remains as the primary option for prophylaxis. Administration of neutralizing mAbs is an immediate and passive immunotherapy with the potential to reduce disease progression, hospitalizations and death. Antibody-based treatments are likely to be more effective if used during the early phase of the illness. Casarivimab together with Imdevimab, holds emergency use authorizations in several countries globally and in India. This review discusses the mechanism of action, current clinical indications, dose, use with other medications and vaccines, duration of protection, protection against variants and evidence of Casarivimab and Imdevimab monoclonal antibody cocktail therapy for mild to moderate COVID-19...
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Posted by admin on Oct 31, 2022 in |
Mesenchymal Stem Cells are multipotent adult stem cells that are found in tissues of the body, including umbilical lines, bone marrow, fat cells, etc. Mesenchymal stem cells incline to self–restore tissues, such as bone, fat cells, connective tissues, and microglia cells, which are obtained from the mesoderm layer and act as macrophages in the central nervous system. So, MSCs can be used to promote functional recovery in many neurological disorders. Neuroinflammation is a pathological feature of neurodegenerative diseases, which is also indicated to mediate neuronal damage and deteriorate the backward accumulation of Aβ in Alzheimer’s disease. The mechanism for MSC-based therapy in Alzheimer’s disease that MSCs regulate neuroinflammation by microglia activation; this will reduce pathological features such as tau hyperphosphorylation and Aβ deposits and save the spatial learning and memory deficits and their multipotentiality and secretome, based on these findings include cell therapy methods for Parkinson disease mainly focused on the ability of stem cells to differentiate into Dopaminergic neurons producing cells that will replace diseased Dopaminergic neurons. MSC-based...
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