Posted by admin on Nov 30, 2024 in |
The chick was chosen as a model because it is more readily available than rats or mice and its organogenesis is analogous to that of humans. Rolapitant is a highly potent, powerful antagonist of the neurokinin-1 receptor, featuring a high degree of infiltration to the brain. The study aimed to assess the morphological and histopathological analysis of the brain (cerebral cortex) of growing chick embryos in response to the rolapitant’s effect. Three hundred fertilised white leghorn chicken eggs were utilised, separated into five control groups (C1 to C5) and five experimental groups (E1 to E5), each with thirty eggs. On the fifth day of incubation, eggs from five experimental groups were exposed to different concentrations of rolapitant at 0.00039 mg, 0.0005 mg, 0.00075 mg, 0.001 mg, and 0.00125 mg respectively, whilst five control groups received the same concentration of normal saline. Chick brains were obtained and weighed. The cerebral cortex (brain) was sectioned and stained to examine the histopathological abnormalities. A significant growth retardation and decreased weight of the...
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Posted by admin on Nov 30, 2024 in |
Isatin is magical molecule widely used in drug discovery of many areas like anticancer, anti-inflammatory, antiviral, anti-convulsant, anti-tubercular, antimicrobial, antidiabetic most important it was found effective in COVID-19 as well as on Lumpy Skin Diseases. Isatin can be synthesized by different methods like Sandmeyer method, Gassman synthesis. Isatin was modified by researchers at C2, C3, C5, position and contribute its magic into the medicinal field. In this research article, main focus has been done on design and docking of various derivatives possessing promising biological activity, novel drug design strategies and their respective drug target. It will provides different approaches to design new drug entity along with docking studies to the young researcher to dig new aspect of...
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Posted by admin on Nov 30, 2024 in |
In the 21st century, human lifestyle has been faster than previous. People of this generation require faster results of each and everything which leads to change in lifestyle. Due to this immediatism invention of rapid release dosage forms are immerging in pharmaceutical market, from which Oral wafer is one of the dosage forms which provides rapid release of the drug. These oral wafers can be administered by oro-mucosal route which can be on the tongue, sublingually or buccal route. It disintegrates in saliva within 14 seconds and dissolution of 99% of drug in saliva has obtained within 60 seconds. There was total three challenges in this research. The antibiotic used in this research was BCS class II drug which leads to poor water solubility which may hamper the rapid action. Extremely bitter taste of drug was the second challenge and Incorporation of high dose in oral wafer was the third challenge. These all challenges have been conquered in this...
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Posted by admin on Nov 30, 2023 in |
Neoadjuvant chemotherapy with Gemcitabine/nab-paclitaxel (Gemcitabine + Nab-Paclitaxel) And Folfirinox (Folfirinox) are two standard therapies for patients who has locally advanced pancreatic cancer (Lapc). We retrospectively compared the efficacy and safety of the two treatment regimens in patients with unresectable pancreatic cancer. The sample size consisted of 96 patients who has locally advanced pancreatic cancer. (Gnp) Gemcitabine and nab–paclitaxel is Group I (N=53), and Folfirinox consisting of leucovorin, fluorouracil, irinotecan and oxaliplatin is Group II (N=43). The Primary objectives of our study were to compare toxicities between gemcitabine + Nab-Paclitaxel And Folfirinox and to evaluate the safety of these regimens The secondary objective was % reduction of tumor, Surgery (% of patients who underwent surgery) and overall survival both estimated using the independent t- test and chi-square test. Results: The haematological toxicities rates were similar between the two groups (62% vs. 63%; p > 0.05), with similar anemia toxicities rates (62%). The neutropenia toxicity rates were similar (15% vs 16%; p>0.05) and febrile neutropenia, thrombocytopenia, and GI toxicities were higher...
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Posted by admin on Nov 30, 2023 in |
Polycystic ovarian syndrome (PCOS) known by its name can be correlated with Soothaga Vaayu in Siddha classical literature which is one of the most common forms of metabolic and endocrine disorders of women, with a high prevalence among the reproductive age group, often associated with obesity, hypertension, insulin resistance, diabetes mellitus, hyperinsulinemia and dyslipidemia. Current therapeutic management available for PCOS is only moderately effective in controlling symptoms and preventing some of the complications. Hence in recent times, people rely most on alternative complementary treatments for the management of PCOS. The research articles have shown the following bio-active compounds present in the selected herbs used in the Siddha treatment for gynecological problems as Campesterol, Diosgenin, Cinnamic acid, Anethole, Kaempferol, Ferulic acid, Myricetin, Erysovine, β-Sitosterol and Rutin. Molecular docking is a great approach in current trends to identify the possibility of pharmacological effects of medicinal compounds which could be exerted over their corresponding protein targets which are relevant for the disease. Docking simulations were performed using the Lamarckian genetic algorithm (LGA)...
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