Posted by admin on Dec 1, 2012 in |
The chemistry of heterocyclic compounds containing five membered 1, 2, 4-triazole nucleus has been an intresting field of study for past few decades. The five membered 1, 2, 4-triazole ring exists in two tautomeric forms i.e., 1H-1, 2, 4-triazole, 4H-1, 2, 4-triazole collectively known as s-triazoles. The s-triazole derivatives possess extensive spectrum of biological activities such as antibacterial, antifungal, antitubercular, anxiolytic, anticonvulsant, anti-inflammatory, analgesic, anticancer, antioxidant activities. The present review provides a broad view of pharmacological activity of compounds bearing 1, 2, 4-triazole nucleus. It can be useful for medicinal chemists to design and develop novel compounds consisting 1, 2, 4-triazole nucleus to get better agents in terms of efficacy and...
Read More
Posted by admin on Dec 1, 2012 in |
Evolvulus aslsinoides is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antioxidant and antiasthmatic activity of ethanol extract of Evolvulus aslsinoides leaves. The present investigation was undertaken to evaluate the histamine-induced bronchospasm of alcoholic extract of Evolvulus aslsinoides leaves in experimental animals. Bronchodilator activity of aqueous extract of Evolvulus aslsinoides leaves studied on the histamine aerosol induced bronchospasm in wister rats. Treatment with alcoholic extract of Evolvulus aslsinoides leaves (250 mg/kg, p.o) showed significant protection against histamine aerosol induced bronchospasm in wister rats. The results of the histamine-induced bronchospasm paradigms demonstrate bronchospasmolytic activity of ethanolic extract of Evolvulus aslsinoides leaves (250 mg/kg, p.o.). Evolvulus aslsinoides leaves shows 41.49% protection against histamine induced bronchoconstriction in rats. These results suggest that aqueous extract of Evolvulus aslsinoides leaves has not only bronchodilating activity but also decreases bronchial hyperreactivity by decreasing the infiltration of inflammatory cells in the airway and inhibition of release of histamine like mediators from the mast cell...
Read More
Posted by admin on Dec 1, 2012 in |
The eye is the most easily reachable organ available for topical drug delivery of local as well as interiorly acting drugs. Ideal drug delivery system aims to provide loading and maintenance dose of drug while being within therapeutic limits at the desired site of action for the desired period of time. In the treatment of ocular disease, the site of action is very narrow and undesired side effects may cause serious injuries to eye tissues. Thus, ideal ocular drug delivery should be site specific, controlled release and non-irritating. Many drugs (more than 85%) belong to BCS class IV exhibiting poor solubility and permeability. Moreover; the precorneal losses like tear secretion, naso-lachrymal drainage and less permeability of corneal tissue causes only 1% absorption of instilled dose. These limitations lead to increased loading dose and dosing frequency to maintain minimum therapeutic level for action which ultimately causes over exposure of drug to eye and leads to serious side effects. Due to these hurdles of conventional drug delivery system, the vesicular drug...
Read More
Posted by admin on Dec 1, 2011 in |
A simple, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed and validated for the estimation of Itraconazole in capsule dosage form. An inertsil C-18, 5μm column having 250 x 4.6mm internal diameter in isocratic mode with mobile phase containing Tetrabutyl ammonium hydrogen sulphate buffer solution and Acetonitrile in the ratio of 40:60v/v was used. The flow rate was 1.5ml/min and effluents were monitored at 225nm. The retention time for Itraconazole was 5.617min. The method was validated for linearity, accuracy, precision, specificity, limit of detection, limit of quantification and robustness. Limit of detection and limit of quantification were found to be 0.85μg/ml and 2.60μg/ml respectively and recovery of Itraconazole from capsule formulation was found to be 98.3 to 100.3%.The system suitability parameters such as theoretical plates and tailing factor were found to be 2927.43 and 1.08 The proposed method was successfully applied for the quantitative determination of Itraconazole in capsule...
Read More
Posted by admin on Dec 1, 2011 in |
The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microspheres of verapamil. Frequent administration and variable low bioavailability (40-60%) after oral administration are problems of conventional dosage forms of verapamil can be attenuated by designing it in the form of mucoadhesive microspheres which would prolong the residence time at the absorption site to facilitate intimate contact with the absorption surface and thereby improve and enhance the bioavailability. Verapamil-loaded mucoadhesive microspheres were successfully prepared by emulsification-internal gelation technique with a maximum incorporation efficiency of 93.29±0.26%. The scanning electron microscopic study indicated that the microspheres were spherical in shape and the drug remained dispersed in the polymer matrix at amorphous state, which was further confirmed by x-ray diffraction analysis. The in vitro wash-off test indicated that the microspheres had good mucoadhesive properties. The wash-off was faster at simulated intestinal fluid (phosphate buffer, pH 7.4) than that at simulated gastric fluid (0.1 M HCl, pH 1.2). The in vitro...
Read More
