Posted by admin on Nov 30, 2023 in |
Introduction: Cervical spondylosis is a degenerative spine disorder commonly affecting the vertebrae and intervertebral discs in the cervical region. Most people commonly present with the complaint of neck pain at least once in their lifetime. It is, therefore, important to ascertain the cause responsible for it. Homoeopathy has a great scope in relieving the pain caused due to spondylosis, thereby preventing the further progress of the disease pathology caused by this disorder. This case was undertaken to assess the efficacy of homoeopathic medicine for managing cervical spondylosis. Case Summary: A 58 years old female complained of neck pain, tingling and numbness with burning over right upper limb for the past 15-20 days. She also complained of headache on and off. No history of vertigo, giddiness was noted. No history of any other major illness was found during the interview. On detailed analysis and repertorization of the case, the homoeopathic medicine Rhus toxicodendron was given. This case was successfully treated with the selected homoeopathic medicine and auxiliary measures, and further...
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Posted by admin on Nov 30, 2023 in |
Breast cancer refers to cancer emerging from breast tissue, commonly from the lobules that supply the ducts with milk or from the inner linings of milk ducts. Due to the mutation of DNA or RNA from the normal cells and abnormal genes when inherited, cancer cells are evolved. LMTK3 (lemur tyrosine kinase 3) has emerged as an important player in breast cancer, contributing to the advancement of disease and the acquisition of resistance to therapy through a strikingly complex set of mechanisms. This prompted us to design newer LMTK3 inhibitors as efficient therapeutic drugs for the treatment of Breast cancer. Based on the common pharmacophoric features for the inhibition of LMTK3, a series of leads were designed using computational methods. A virtual library consisting of newly designed 100 molecules as LMTK3 inhibitors was constructed. Based on these facts, a scaffold library has been created with 100 newly designed ligands containing aromatic rings, Imidazole, pyrrole, indole, benzimidazole, morpholine, benzothiazole, pyrazine, quinoxaline, pyridine, indolinone, oxazole, quinolizine as LMTK3 inhibitors. The binding...
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Posted by admin on Nov 30, 2023 in |
Immunotherapy is among cancer immunology’s fastest and most furious treatment strategies. The therapeutic perspective of checkpoint inhibitors is represented through the Food and Drug Administration (FDA) approvals for their implementation in various malignancies. Efforts to improve results with immunotherapeutic agents have led to the design of advanced treatment strategies. Current pre-clinical evidence estimating immune checkpoint inhibitors in several cancer cell lines has recommended that combinatorial approaches may have better survival results than monotherapy. Experimental trials evaluating combined therapy with anti-PD-1/ PD-L1 plus anti-CTLA-4 checkpoint inhibitors have reported considerable leads in survival indices over single immunotherapy. The therapeutic prospective of combinatorial approaches is focused on nivolumab with ipilimumab for advanced melanoma patients. Combined checkpoint inhibition with anti-PD-1/PD-L1 plus anti-CTLA-4 monoclonal antibodies is being estimated for broadly cancer histological...
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Posted by admin on Nov 30, 2023 in |
With a threshold of 3 DSM-1, rice is one of the crops that are most sensitive to salt. Salinity in agricultural areas is primarily brought on by the overuse of irrigation water that is overly salty. The early vegetative and seedling stages of rice are the most vulnerable to salt stress, followed by the reproductive phases. When osmotic stress inhibits root water uptake, too much salt in the soil hurts plant growth, development, and productivity. Direct salt buildup impairs metabolic functions and all key morphological-physiological and yield-related features, drastically reducing yield. To investigate the cellular basis of the response to salt stress, extensive analysis involving physiological or biochemical assays and gene expression studies under high salt regimes is reviewed and contrasted with an aromatic salt-sensitive (Chinigura) and non-aromatic salt tolerant (IET 4786) rice variety. The detrimental effects of salinity stress were most evident in Chinigura, where the root-to-shoot ratio was higher, chlorophyll degeneration was more severe, foliar concentrations of Na+ ions were higher, and peroxide content increased most after...
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Posted by admin on Nov 30, 2023 in |
“Quality by Design” (QbD) serves as a bridge between industry and drug regulatory authorities to move towards a scientific, risk based holistic and proactive approach for development of pharmaceutical products. So, the present work describes the development of RP-HPLC method for simultaneous estimation of azelnidipine and telmisartan in pharmaceutical dosage form by QbD approach. The Box-Behnken design was used for screening where the effect of flow rate, % organic phase and temperature on retention time, resolution, number of theoretical plates (NTP) and symmetry factor (critical quality attributes) was evaluated. Chromatogram was run through Discovery C18 250 x 4.6 mm, 5m. Mobile phase containing 0.01N Ortho Phosphoric Acid: Acetonitrile taken in the ratio of 53.8:46.2V/V was pumped through column at a flow rate of 0.9 ml/min. The developed method was validated according to guidelines of the International Conference on Harmonization (ICH). Hence, the developed method using QbD approach was better understood that, reduces the time and cost of the...
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