Posted by admin on Nov 30, 2022 in |
The effect of many plant extracts and microbial biopesticides on insects’ different developmental stages and physiology have been widely studied from time to time, but the effect of microbial biopesticides on the mosquito tissues, especially mid gut tissues, is very few. Since the malaria vector is one of the most important inclusions in human health and mosquito-borne diseases represent a great health threat in tropical and sub-tropical climates, it is quiet logical to know the detailed mode of action of fungus on Anopheles stephensi (L.) larvae after assessing the bio toxicity. In the present study, we have mainly emphasized the midgut of Anopheles stephensi (L.) to understand better the larvicidal action of fungal biopesticide Beauveria bassiana (Balsamo). After treatment with the fungus Beauveria bassiana (Balsamo), the cytopathic effects of the fungus were widespread along the whole anterior and posterior part of the midgut...
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Posted by admin on Nov 30, 2022 in |
Purpose: The goal of this study was to develop taste-masked orally disintegrating tablets of the bitter-tasting levocetirizine dihydrochloride (LCDH) to improve the accessibility and adherence of pediatric, elderly, non-cooperative and paraplegic patients. Methods: In the present study, orally disintegrating Levocetirizine dihydrochloride tablets were formulated by direct compression. Taste masking was achieved using a pH-independent polymeric dispersion of Surelease E-7-19040 in combination with Opadry YS-1-19025-A in different ratios. In-vivo taste evaluation was done to see if the tablets produced utilizing the direct compression approach were successfully disguised. Results: The present study investigated uncoated and coated drug substances and prepared tablets of coated LCDH for flow as well as compression behaviour, Fourier Transform Infrared absorption spectra, Differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy and in-vitro dissolution and disintegration properties. Conclusion: Using a combination of two polymeric dispersions “Sure lease E-1-19040” and “Opadry” coating for the delivery of LCDH, it was shown that a taste-masking evaluation could be performed to identify effective polymer-carriers for the...
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Posted by admin on Nov 30, 2022 in |
Introduction: SSI (Surgical site infection) is the dreaded complication following orthopaedic surgery. The main source of surgical site infection is the patient’s own skin flora. So skin preparation plays a major role in preventing the SSI. This study aims to compare povidone-iodine and 2% chlorohexidine alcohol in pre-operative skin preparation in elective orthopedic surgery and followed uo for 4 weeks for and postop SSI. Methods:This was a prospective study of 30 patients who underwent elective orthopaedic procedures between October 2021 to November 2021 with a follow-up duration of 4 weeks. A group of 30 patients of both sexes, different age groups with associated co-morbidities were included in our study. Results: They were divided into 2 groups of 15. Group-1 consisted of 9 males and 6 females; their mean age was 51, of which 9 had associated co-morbidities. Group-2 consisted of 8 males and 7 females. There were statistical differences (p<0.05) between co-morbidites in both groups and no statistical difference in risk factors between the two groups in terms of...
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Posted by admin on Nov 30, 2022 in |
Background: Hoffa fracture management is almost always surgical since it involves the intraarticular part of the femur. It can be managed either with cannulated cancellous screw alone or with the addition of a buttress plate. The study aimed to evaluate and compare the functional outcome of fracture fixation between the CC screw &CC screw with a buttress plate. Method: This was a prospective study of 30 patients with Hoffa fracture conducted between January 2020 to December 2021. Patients were allotted into 2 groups. Group A was treated with CC screw fixation, Group B was treated with CC screw + buttress plate. Post-operatively, follow-up was done for 1 year. Results: There were 14 males and 16 females in our study with both sides equally injured. The mean age of patients was 36.1 ranging from 23 to 52 years. RTA was the most common mode of injury. The average blood loss during group A was 117 ml and for group, B was 182.1 ml which is statistically significant. The average postoperative...
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Posted by admin on Nov 30, 2022 in |
Cancer has evolved as a detrimental disorder alongside cardiovascular diseases. Plant-derived natural products have been the most successful source of potential anti-cancer drugs and for the isolation and characterization of novel compounds. Till now, only about 10% of the world’s biodiversity has been assessed for biological activity and numerous useful natural lead compounds are expected to be discovered in the near future. The exploration for anti-cancer agents from plant sources commenced in 1950s with the discovery of alkaloids; vinblastine and vincristine from Catharanthus roseus and the segregation of the cytotoxic podophyllotoxins from Podophyllum peltatum. Subsequently, paclitaxel or taxol was isolated from Taxus brevifolia bark and camptothecin was isolated from Camptotheca acuminata. Likewise, homoharringtonine, elliptinium, combretastatin A-4 betulinic acid, pervilleine-A, silvesterol, schischkinnin, and montamine are some of the other effective plant-originated anti-cancer compounds. With the developments in structural chemistry, a range of synthetic and semisynthetic lead compounds were designed and developed in laboratories. For instance, the semisynthetic analogues of vinca alkaloids are vinorelbine and vindesine, which are used either alone...
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