Posted by admin on Nov 30, 2019 in |
The skin is the largest organ of the human body and easily accessible. It’s potential as an alternative route for administering drugs for both systemic and local effects has attracted considerable interest. Most of the topical medications which are applied on the skin or mucous membrane to treat ailments include a wide range of creams, foams, gels, lotions, ointments, eye drops, ear drops, etc. Topical drug delivery provides a convenient and effective system for the treatment of local pathological conditions (dermal drug delivery) or as the site for systemic drug administration (transdermal drug delivery). Nanostructured Lipid Carriers (NLCs) are drug-delivery systems composed of both solid and liquid lipids as a core matrix. It has been shown that NLCs exhibit several advantages for drug therapy over conventional carriers including increased solubility and stability, improved permeability and bioavailability, reduced adverse effects, prolonged half-life, and tissue-targeted delivery. NLCs have attracted expanding scientific and commercial vigilance in the last couple of years as alternate carriers for the pharmaceuticals. A new generation of NLCs...
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Posted by admin on Nov 30, 2019 in |
In recent years, there is an increasing interest in finding antioxidant phytochemicals for the prevention and treatment of complex diseases like diabetes, cancer, and atherosclerosis, which are associated with excessive biological oxidative stress. Plants are rich source of natural antioxidants that inhibit the propagation of free radical reactions and protect the human body from degenerative diseases. For the present study, entire vine (aerial part) of Cyclea peltata was selected based on their extensive use in folk medicine and ayurvedic medicine to cure various ailments. Hexane, chloroform, ethyl acetate, methanol and water extracts of Cyclea peltata were subjected to various in-vitro antioxidant activity studies. In most of the antioxidant parameters, ethyl acetate and methanol extracts showed potent activity and chloroform extract showed minimum antioxidant activity. From these studies, it can be concluded that ethyl acetate and methanol extracts of Cyclea peltata could be used as a source of potent natural antioxidant that can be used in various plant-based drugs or formulations for the treatment of complex diseases caused due to...
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Posted by admin on Nov 30, 2019 in |
In different myeloid leukemia cases resistance to diverse treatment regimen owes to multiple molecular mechanisms of cellular network. Epigenetic dysregulation, gene mutations, overexpression of multidrug resistance genes, abnormal immune function, the presence of chemotherapy-resistant leukemia-initiating cells, and aberrant signaling pathways could be the lead cause of this kind of aberration. Some marketed drug is considered as a first-generation drug that can inhibit the enzymatic action by inhibiting the ATP binding with different key pathway regulator protein. Later on, insensitivity of myeloid leukemia cells towards these drugs has been observed may be due to mutation in tyrosine kinase domain of the kinase receptor. By enchanting into account of bioavailability and resistance developed, there is an extreme need to find some natural and nature-derived inhibitors for the kinase proteins of different key metabolic pathways. For computational screening and in-vitro studies against cancer cell lines and marker proteins, Mangiferin and Euxanthic acid isolated from leaves of Mangifera indiaca had been used as mentioned in Ayurveda / Indian Traditional Medicine (ITM). Docking analysis...
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Posted by admin on Nov 30, 2019 in |
Objective: Wedelolactone is a naturally (WDL) occurring coumestan of phytoestrogen category that possess anticancer and anti-inflammatory property. In this study, the anti-inflammatory effect of WDL on human cervical cancer cells (HeLa) and initiation of apoptosis mechanism were investigated. Methods: MTT assay and Trypan blue assay were demonstrated to detect the inhibitory effects of WDL on cell proliferation. The mRNA expression of IL-1β, TNFα, IL-6, TGFβ, and NFκB were detected by RT PCR. Western blotting was performed to detect the expression of apoptosis-associated proteins; cleaved caspase-3, cleaved PARP, Bcl-2, and Bax. Results: WDL significantly inhibited the growth and proliferation of HeLa cells in a concentration dependent manner with the IC50 of 10µM. mRNA expression of inflammatory cytokines and NFκB was significantly reduced in WDL treated groups. Moreover, WDL promoted the apoptosis of HeLa cells dose-dependently by down-regulating Bcl-2 and up-regulating cleaved caspase-3, cleaved PARP, and Bax. Conclusion: Collectively, WDL exerted anti-inflammatory effect through the suppression of NF-kB activation, IL-1β, TNFα, IL-6 and promoted apoptosis in HeLa cells. Thus, use of...
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Posted by admin on Nov 30, 2019 in |
Osteomyelitis is a very serious disease caused by bacteria, especially Staphylococcus aureus, which directly attacks the bones tissues. Many physicians and surgeons are still looking for the basic cure of the disease. This article mainly focuses on the different kinds of treatments using new drug formulations. Vancomycin coated with chitosan polymers, biodegradable scaffolds, use of major limb amputations with a modified Lautenbach technique, and use of telavancin drug for outpatients is currently used for the treatment of osteomyelitis. Osteomyelitis is classified based on the cause of the disease and also the treatment. Many research works have been carried out which gives us prospects for the treatment of the disease. The pros and cons associated with different methods used for the treatment of the disease are discussed. These methods give us a better idea about the treatment of the disease and also helps in restricting the disease without causing larger damage. The usage of PMMA beads has shown better results for the treatment of Chronic...
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