Posted by admin on May 31, 2025 in |
In recent days some groups are seeking infertility treatment, on the other hand there are groups seeking contraception methods. Nowadays there are several ways are available for contraception such are Oral contraceptive pills, implants, injectable, patches, rings, intra uterine devices, Male and Female sterilization and so on. WHO stated that the number of women desiring to use family planning has increased markedly over the past two decades from 900 million in year 2000 and 1.1 billion in the year 2021. Between 2000 to 2020 the contraceptive prevalence rate increased from 47.7 to 49%. WHO assists countries to adapt and implement contraception tools to strengthen contraceptive policies and programs. Siddhars, who were the founders of Siddha Medicine. From their insights they told lot of medicines for all health ailments. Even for disease prevention, diagnosis and to cure the disease. Siddha literature evidenced that the natural contraception method by using herbal drugs which would be effective. Poovarasan (Thespesia populnea) tree bark, Induppu (Rock or pink salt) and Kaaichukatti (Acacia catechu) taken...
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Posted by admin on May 31, 2025 in |
Medicinal plants are of great importance to researchers in the field of pharmacology as most pharmaceutical industries depend on medicinal plant for their raw materials. Meyna laxiflora belongs to the family Rubaceae and is well known for its medicinal properties. The present study was carried out in continuation of our previous findings to determine the possible bioactive components present in the aqueous and methanolic extracts of Meyna laxiflora fruit pulp. The gas chromatography – Mass spectrometry was used for identification of the bioactive compounds in the extracts and the spectrums of unknown compounds were compared with the compounds stored in the National Institute of Standards and Technology Mass Spectral database (NIST). The GC-MS analysis revealed the presence of 37 peaks in aqueous extract among these 19 were found to be major compounds while that of methanolic extract showed 24 peaks of which 15 were found to be major compounds. Hence, the present study has generated baseline data for further characterization of fruit pulp extract of this...
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Posted by admin on May 31, 2025 in |
Momordica cymbalaria, an underexplored vegetable crop native to India, holds significant therapeutic potential due to its traditional antidiabetic use. This study explores its phylogenetic characterization, protein structure modelling, and phytochemical profiling, emphasizing its role in diabetes management. The 5.8S rRNA internal transcribed spacer sequence was retrieved from NCBI and analysed using BLAST, identifying 17 related species and insights into its evolutionary positioning. Phylogenetic analysis revealed close relationships with Momordi cafoetida and distant similarity to Momordica balsamina. Protein structure prediction using SWISS-MODEL and PyMOL identified key structural features and active sites. Three open reading frames (ORFs) were identified, potentially encoding proteins involved in diabetes-related pathways. Phytochemical analysis using Dr. Duke’s and IMPPAT databases highlighted bioactive compounds such as beta-sitosterol, ergosterol, and alpha-eleostearic acid (ESA), a potent antidiabetic compound. ESA modulates the adipose deposition pathway and improves glucose regulation by interacting with proteins like peroxisome proliferator-activated receptor gamma (PPARG) and ribosomal protein L19. In-silico analysis demonstrated ESA’s ability to enhance GLUT-4 and beta-glucokinase activity, facilitating glucose uptake and improving metabolic efficiency....
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Posted by admin on May 31, 2025 in |
The most widely used cationic dye, methyl violet (MV), has significant carcinogenic potential. The textile, cosmetic, printing, pharmaceutical, and food processing sectors all make extensive use of artificial dyes. They are typically referred to as xenobiotics because of their strong resistance to biodegradation. Microbes are beneficial because of their rapid growth and ability to break down and mineralise dyes. Methyl violet-degrading Enterobacter sp. was isolated from the Ganges River. It degrades up to 180 ppm of methyl violet in 24 hours when shaken at 25°C – 45ºC and pH 1 -12; optimum degradation occurs at 40 ppm in 24 hours at pH 7.0. The effects of temperature, initial pH, and dye concentration were investigated. The capacity of bacteria to degrade was demonstrated by experimental results. The deterioration of methyl violet was validated by UV-Vis spectroscopy, SEM, and FTIR examination of samples both before and after dye breakdown in culture...
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Posted by admin on May 31, 2025 in |
The fossa of Rosenmuller is the most common site of NPC. It arises from the lining mucosa of the nasopharynx. Around one-fifth of NPC patients presented with cranial nerve palsy. The tumor can penetrate the skull and surrounding cranial nerves because fossa of Rosenmuller is situated next to the foramen lacerum. A 57-year-old male patient arrived at the medical college and Hospital, Kolkata ENT opd complaining of headache, fullness in his ears, a mass on his left neck, and nosebleeds. The patient’s vision was normal. Following a comprehensive physical examination, radiography, histology, and history taking following examinations, the patient was identified as having House Brackmann III facial nerve palsy at the level of the mastoid segment and WHO 3 ECOG I T4N2M0 stage III NPC. A regimen of paclitaxel-cisplatin for six rounds was administered. In conclusion, NPC has the unusual potential to result in facial nerve...
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