Posted by admin on May 31, 2022 in |
Oroxylum indicum (O. indicum), commonly known as the Indian trumpet tree, belonging to the family Bignoniaceae, is a medicinally important, small, or medium-sized plant used to treat various diseases and also has its importance in the traditional system of medicine. Various parts of the plant have been proved to possess useful pharmacological activities. It is native to the Indian subcontinent, extending to Sri Lanka, China, and Malaysia. A variety of experimental studies has been performed both in-vitro and in-vivo to determine the various uses of the plant. Also, various important chemical constituents have been isolated, which act as a source of medicinally important compounds. Flavonoids, the most abundant and important constituents, are found in almost all parts of the plant. Several studies have been performed to reveal information on O. indicum. The aim of writing this review is to compile information from published materials on various aspects of the...
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Posted by admin on May 31, 2022 in |
During the past few years, diabetes has been one of the leading metabolic disorders. It occurs when the body does not produce enough insulin or the body cells are not efficient enough to take up the insulin. This increases blood glucose levels that affect the body system, particularly blood vessels and nerves. Due to the side effects of allopathic medicines, individuals are searching the other alternatives with lesser side effects and more efficacy. Such properties are present in plant-based product. Picrorhiza kurroa Royle ex. Benth. belonging to the family Plantaginaceae/Scrophulariaceae distributed in Himalayan regions of China, Pakistan, India, Bhutan and Nepal. The tribes of North–Eastern Himalayan regions of India use this herb as for controlling diabetes. The present study was conducted to evaluate the antidiabetic activity of ethanolic extract of P. kurroa in-vitro and in-vivo. In-vitro antidiabetic activity was done by inhibiting the alpha-amylase enzyme, which is hydrolyzing enzyme for the starch by plant extract. In-vivo antidiabetic activity was done by injecting alloxan monohydrate (120 mg/kg bw) to male...
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Posted by admin on May 31, 2022 in |
Obesity and overweight have recently drawn greater attention due to their central role in the rapid increase of metabolic syndrome disorders. The research pursuit for exploring novel and effective therapeutic alternatives to deal with obesity ailments and oxidative stress has received immense interest. In this study, different solvent fractions of Nigella sativa (N. sativa; Black cumin) seeds were prepared and their phytochemical analysis was done. Among different solvent fractions, the methanolic fraction of N. sativa (MFNS) contained a high level of polyphenols (451.77 ± 0.91 μg/mL) and flavonoids (401.24 ± 0.73 μg/mL). The GC-MS analysis of MFNS showed the presence of several glycosides, oils, and polyphenolic compounds, as mentioned in the results section. The effect of N. sativa seed fractions on inhibition of key digestive enzymes linked to adiposity such as α-amylase, α-glucosidase and pancreatic lipase was evaluated. The free radical scavenging activity of seed fractions was studied through standard antioxidant assays (DPPH and NO). The enzyme inhibitory effect of MFNS for α-amylase, α-glucosidase and pancreatic lipase was 81.47%,...
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Posted by admin on May 31, 2022 in |
At a time where we understand that new drug discovery and development involves significant cost, expensive products and is the slow-paced process, an innovative idea called ‘Drug Repositioning’, which basically means repurposing of old drugs to treat diseases including both common and rare are being increasingly attractive as it provides drug development in a sustainable cost, time efficiently and the product value is also low, making it less risky for pharmaceutical investment. A drug initially marketed as an anti-anginal drug repurposed for erectile dysfunction (Sildenafil/ Viagra) is an important example of landmark evidence in history. Similarly, over the years, several drugs have been successfully repurposed into other drug uses to treat various diseases. In this systematic review article, we have focused on the wholesome idea and methodologies of drug repurposing and its approaches, methods, challenges and strategic advantages over traditional drug discovery in the present...
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Posted by admin on May 31, 2022 in |
This study was designed to evaluate and compare the Antidepressant effect of Ibandronate with Amitriptyline on depression models in albino mice. Eighteen Swiss albino mice weighing 20-25 grams were selected and divided into three groups of six animals each. Group 1: Normal Saline- 0.5 ml, Group 2: Amitriptyline – 39 mg/kg, Group 3: Ibandronate 0.325 mg/kg administered orally every day for 30 days. Animals were subjected to a forced swim test, tail suspension test, and Locomotor activity test on 1st, 10th, 20th and 30th day of the experiment after 1 hour of drug administration. The forced swimming test and Tail suspension test detected the duration of immobility, whereas the Actophotometer test detected the influence of the drug on the Locomotor system. The data reveal that Ibandronate has an antidepressant action that did not differ significantly from Amitriptyline. Ibandronate a Bisphosphonate has shown an antidepressant effect on depression models in albino...
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