Posted by admin on May 31, 2021 in |
Tea tree oil, an essential oil, has claims for analgesic, antimicrobial, antiseptic, and anti-inflammatory activity. Its complex composition is governed by ISO 4730:2017. It is extensively used in skin and hair care cosmeceuticals, often in combination with neem seed oil. Neem seed oil has potent antimicrobial, skin rejuvenating, and conditioning action attributed to the presence of micro constituents and complex lipid composition of triglycerides, diglycerides, and monoglycerides of both saturated and unsaturated fatty acids. Although few methods are available for estimation of individual oils, simple spectrophotometric methods suitable for routine determination of either oil or for simultaneous estimation of both the oils are not reported. A novel, simple, validated UV spectrophotometric method for simultaneous estimation of tea tree oil and neem seed oil in bulk and cosmeceutical formulation has been developed after optimization and validation of UV spectrophotometric method for individual estimation of oils. The method relies on the measurement of absorbance at 267nm and 284nm, λmax of tea tree oil, and neem seed oil, respectively. Linearity is established...
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Posted by admin on May 31, 2021 in |
Next-generation printing or commonly known as three-dimensional (3D) printing (3DP), is a fabrication process of construction of a 3D object using a computer-aided design or digital 3D model. The 3D object is created layer by layer by depositing, joining, or solidifying a feedstock material such as thermoplastic polymer under the control of a computer-designed program. It is considered the latest technology that has the potential to address complex medical and pharmaceutical problems, such as prototyping essential medical devices, equipment, and novel drug delivery systems. The ability of 3DP to produce medications with accurate specifications tailored to the needs of individual patients has indicated the possibility of developing personalized medicines. The technology allows dosage forms to be precisely printed in various shapes, sizes, and textures, in a limited time period. In spite of many potential medical and economic benefits of 3DP, some technical and regulatory challenges are associated with the widespread application of 3DPin the pharmaceutical sector; those need to be addressed by proper research so that the benefit of...
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Posted by admin on May 31, 2021 in |
Coronavirus disease (COVID-19), an infectious disease caused by a novel coronavirus (2019-nCoV) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection began in bats and was communicated to people through yet obscure go-between creatures in Wuhan, Hubei territory, China, in December 2019. Its outbreak threatened the lives of many people throughout the world. There is no distinct treatment available yet, and is an urgent need to treat, prevent and eradicate this virus. Recently, numerous new technologies have been explored for the diagnosis, prevention, and treatment of viral infections. Among these, nanotechnology has emerged as a promising antiviral treatment, and currently, the development of COVID-19 drug delivery involving nanotechnology is under investigation. This review aimed towards the prospective treatment options integrating the ever-expanding field of nanotechnology against COVID-19. We focused on the current scenario in the developments of nanotechnology-based approaches because of the ongoing pandemic of COVID-19, the effectiveness of nanomaterials as vaccines, nanosensors as diagnostic or antiviral tools against coronaviruses, and post COVID-19 era has been discussed...
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Posted by admin on May 31, 2021 in |
Oral Conventional dosage forms offer no control over the release of drug from the dosage form, which leads to variations in plasma drug levels; gastric emptying and gastric resident time are two another important factors that have a significant effect on the therapeutic efficacy of drug and it causes changes in the retention time of the drug. Accordingly, Floating microspheres is one of the most dependable and inventive techniques among all the gastro retentive drug delivery systems to overcome from these problems. Floating microspheres are mainly obtaining importance because of their vast suitability in the targeting of drugs to the stomach, undergo action and scattered uniformly over the gastric fluid to avoid the changes of gastric emptying and enlarge the liberation of the drug. This system also allows vastly in the fabrication of new controlled and delayed-release oral formulations, thus Expanding revolutions in pharmaceutical Expansion. The present review, in brief, says the physiology of the Intestinal gastric tract and elements governs the gastro retentive drug delivery system. This review...
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Posted by admin on May 31, 2021 in |
The purpose of this research was to obtain directly compressible agglomerates of simvastatin using a crystallo-co-agglomeration technique and determine its in-vivo performance in rats. Simvastatin Dicalcium phosphate co agglomerates were prepared from Dichloromethane: Isopropyl Myristate: Distilled water system containing polyvinyl pyrrolidone (PVP). Dichloromethane acted as a good solvent for simvastatin, the water acted as a bad solvent, and isopropyl myristate acted as a bridging liquid for agglomeration. 23 factorial design was used for optimization, wherein the factors were stirring speed, polymer concentration, and amount of bridging liquid. The responses evaluated were dissolution, b value, and Carr’s index. The agglomerates were characterized by powder x-ray diffraction (PXRD), which showed that there is a decrease in crystallinity or partial amorphization of the drug in its agglomerated form. Micromeritic and compression properties of the agglomerates were affected by an incorporated polymer. Dissolution of agglomerates (91.73%) increased as compared to a pure drug (25.96%). The agglomeration increased the flow property of Simvastatin which was indicated by Carr’s index of a drug (40.81) and an...
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