Posted by admin on May 31, 2020 in |
Dandruff is a well-known and global consumer problem, characterized by flaking and scaling of the scalp, with itching and irritation. Although it is not a life-threatening disease, but it is directly related to individual self-esteem, confidence, and beauty. Approximately half of the population is suffering from dandruff and expending around billions of dollars, including hospital services and counter products. Despite its frequency, much controversy remains regarding the pathogenesis of dandruff. Many studies postulated that dandruff is caused by various microbial and non–microbial factors and interaction between them, such as Malassezia fungi, sebum secretion, and individual susceptibility. But some recent researches also claimed that dandruff is not only produced by fungi but there are some bacteria that also play a significant role in accelerating dandruff. The present treatment includes antifungal agents, no doubt, they have significant results but with lots of side effects and limitations. So, there’s a need to formulate a cost-effective product that possesses anti-dandruff activity, and Zulamla (Hamdard Laboratory Patent Product) is used and is in the...
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Posted by admin on May 31, 2020 in |
Substituted triazoles have received considerable attention during the last two decades as they are endowed with a variety of biological activities and have a wide range of therapeutic properties. The present work is concerned with the synthesis of fused 1, 2, 4-triazole derivatives with the objective of discovering novel and potent anti-tubercular agents that might be devoid of harmful side effects. 1-[amino (isonicotinoyl) carbonohydrazonoyl] guanidine (I) was prepared from isoniazide and cyanoguanidine and was cyclized to 2-(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl) guanidine (II) which was further converted into amino triazolo triazine derivatives (IIIa-g) by refluxing with the appropriately substituted benzaldehydes. The final compounds 10-substituted-2-(pyridin-4-yl)-6,10-dihydro-5H-pyrimido[2,d] [1,2,4] triazolo[1,5-a] [1,3,5] triazine-6-carboxylic acid (IVa-g) were obtained by refluxing different amino triazolo triazine derivatives (IIIa-g) with formaldehyde and sodium pyruvate in presence of HCl in methanolic medium. The newly synthesized compounds were screened for their antitubercular activity using a microplate alamar blue assay method and characterized on the basis of IR, 1HNMR and Mass spectral...
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Posted by admin on May 31, 2020 in |
In folk medicine, especially in developing countries, several plant species are employed for the treatment of snakebites that lack prompt access to serum therapy. Andrographis serpyllifolia (Vahl), belonging to Acanthaceae, has been recorded in ethnobotanical archives as a plant possessing potent anti-ophidic activity for snake bites. The present study emphasis to investigate the phytochemical profile and anti-oxidant properties of various plant extracts of A. serpyllifolia. To carry out this work, various cold plant extracts were prepared from shade dried leaves and used. During qualitative analysis, all the plant extracts showed positive results for all phytocompounds. Various quantitative assays exhibited that all plant extracts were having significant level of secondary metabolites with values ranging from 1148 to 286 mg GAE/g for phenol, 1262 to 976 mg LN/g for terpenoids, 172 to 106 mg RE/g for flavonoids and 21.5 to 3.6 mg TA/g for tannins. All the plant extracts tested had higher DPPH, ABTS scavenging activity, and metal chelating ability. The free radical scavenging activity of plant extracts were found to...
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Posted by admin on May 31, 2020 in |
Herbal medicine has been widely accepted as a promising approach for the treatment of various diseases with lower cost and minimized toxicity. Bioactive constituents isolated from the herbal source are equipped with synthetic drugs. The potency of any herbal medication is contingent on the delivery of the effectual level of the therapeutically active constituent. The integration of a novel drug delivery system in a traditional system of medicine enriches the potentiality of herbal drugs. Several plant extracts and phytoconstituents, despite having excellent bio-activity in-vitro demonstrate less or no in-vivo actions due to their poor lipid solubility or improper molecular size or both, resulting in poor absorption and poor bioavailability. Nan technological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus, obtain a greater bioavailability. Phytosome technology is one such novel approach that enabled in making phytoconstituents more bioavailable. In this review, a comprehensive discussion with respect to the methods and characterization of nanophytosomes of herbal preparations is...
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Posted by admin on May 31, 2020 in |
Nitrofurantoin is a broad-spectrum bactericidal antibiotic that affects both gram-negative and gram-positive bacteria. Nitrofurantoin exhibits bacteriostatic or bactericidal effects by inhibiting the synthesis of DNA, RNA, protein, and cell wall synthesis. Nanocrystals of NFT were prepared by a cold high-pressure homogenization technique. To improve the dissolution rate, the drug was formulated in a nanocrystal by using an emulsion diffusion method, high-pressure homo-genization or sonication. NFT was dispersed in aqueous surfactant solution containing poloxamer 188, PVPK 30, and HPMC E3 under continuous stirring. Poloxamer 188 was used as a surfactant for the preparation of the NCs. Formulation NC9B3 has a mean particle size 231 ± 9 nm with polydispersity index 0.09 ± 0.02, which indicates a very narrow particle size distribution. % Entrapment efficiency was 98.3 ± 0.7 slow drug release profile indicates the homogeneous dispersion of NFT in the lipid matrix. NCs have crystalline nature with rough surfaces, which has been confirmed using SEM analysis. XRPD spectra show the reduction in the crystalline behavior of the drug and the...
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