Posted by admin on Apr 1, 2010 in |
The hepatoprotective activity of juice of Saccharum officinarum was investigated against paracetamol (acetaminophen) induced liver damage in rats. Paracetamol (PCM) is analgesic, antipyretics drugs available as an over the counter (OTC) medication which cause hepatotoxicity as higher doses. Paracetamol at 3gm/kg induced liver damage in rats manifested by statically increased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), total and direct billirubin. The antioxidant parameter malondialdehyde (MDA) level was increase and reduced glutathione (GHS), total protein (TP) level were decrease. The physical parameter of liver weight and volume also increase. Histopatholgical and in vitro (% of cell viability) studies of the experimental animals were also done. The results indicate that the juice of Saccharum officinarum protects against PCM-induced hepatotoxicity presumably via antioxidant action....
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Posted by admin on Apr 1, 2010 in |
Ketoprofen is a non-steroidal anti-inflammatory drug. Glucopyranoside Conjugates of Ketoprofen have been synthesized and evaluated for anti- inflammatory, analgesic and ulcerogenic activities. In vivo biological screening in mice and rats indicated that conjugates improved analgesic and anti-inflammatory activities with significantly reduced ulcerogenicity compared to the parent...
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Posted by admin on Apr 1, 2010 in |
The study is aimed at development of Physico-chemical parameters and to investigate the active principle present in Chlorophytum borivilianum. Chlorophytum borivilianum San. and Fern. (Liliaceae) commonly known as Safed Musli is an important plant used against various disorders in indigenous systems of medicine, such as antioxidant, analgesic, and as a remedy for male impotence and to boost the immune system. This plant is to be considered as an endangered plant due to its potent use in many of the tribal areas in India and used widely in Traditional System of Medicine. Thus from extensive literature survey it was revealed that no reports were available on microscopic evaluation, standardization parameters and chemoprofile of Chlorophytum borivilianum to check the identity and purity of the drug. The present work embodies the investigations carried out to establish methods for quality control of drugs as per WHO guidelines: complete botanical evaluation which comprises of macroscopy, microscopy, physico-chemical parameters like Loss on Drying, Extractive values, Foaming index, Ash values and to investigate the phytochemical present...
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Posted by admin on Apr 1, 2010 in |
In present study, in vitro methods were selected to test and compare the antioxidant activity at different levels involving formation and scavenging of free radical by extract of Butea monosperma flowers (EBMF). The total phenolic content of EBMF was found to be 19.09 mg (equivalent to gallic acid) per gram of extract. In addition, reducing power was found to be increase with the increasing concentration of extract. The extract exhibited concentration dependant radical scavenging activity in DPPH with IC50 value- 47. 2 µg/ml. All the above in vitro studies clearly indicate that the EBMF posses a significant antioxidant...
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Posted by admin on Apr 1, 2010 in |
Anti-inflammatory activity of the ethanolic extract of the Cissampelos pariera Linn leaves was studied in albino wistar rats using the carrageenan induced rat paw edema model. The ethanolic extract of Cissampelos pariera (400 mg/kg p.o.) inhibited carrageenan induced rat paw edema. The extract was also studied for its preliminary phytochemical screening and acute toxicity studies. The result indicated that the extract produced significant (P < 0.05) anti-inflammatory activity when compared with the standard drug indomethacin (10 mg/kg p. o.) and untreated...
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