Posted by admin on May 1, 2010 in |
The present endeavour was directed towards fabrication of the novel colon drug delivery system of ketorolac tromethamine capsule. Hard gelatin Capsules were fabricated using combination of both microflora activated natural polysaccharide (guar gum) and pH-dependent polymer (cellulose acetate phthalate). In vitro drug release studies revealed that Ketorolac tromethamine granules bearing hard gelatin capsules coated with cellulose acetate phthalate released drug only at higher pH (6.8 PBS), in vitro drug release studies showed that capsules were retained in stomach pH (1.2 N HCl) with-out any drug release, whereas minimal amount of drug release in small intestine pH (7.4 PBS) and almost drug release showed in the colonic pH (6.8 PBS). The rate of drug release was observed fast with caecal content (4% w/w rat caecal) than the control medium. Hence 50% guar gum containing coated capsules may be potentially useful for delivery of ketorolac tromethamine for colon. The drug release follows case ІІ (non- fickian) diffusion control...
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Posted by admin on May 1, 2010 in |
The plant Tephrosia purpurea L. is commonly known as Unhali. T. purpurea (Leguminosae) is a copiously branched perennial herb. Present work was undertaken to study antioxidant potential of the plant. Dried ethanol and aqueous extracts plant were screened for in-vitro antioxidant activity by DPPH assay and nitric oxide screening methods. Results showed that IC50 value of aqueous extract in DPPH assay and nitric oxide scavenging assay are 78 ug/ml and 89 ug/ml respectively. Phytochemical screening revealed that flavonoids, alkaloids, saponins, tannins and phenolic compound are present in aqueous extract and may be responsible for the activity. It can be concluded that the aqueous extract of T. purpurea L. root can be used as antioxidant and it can be recommended for the treatment of various...
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Posted by admin on May 1, 2010 in |
Despite of tremendous advancement in drug delivery the oral route of drug administration is the most important method of administration of drug for systemic effect. The parenteral route is not routinely used for self administration of medication. It has been known for centuries that buccal and sublingual administration of drug solute is rapidly absorbed into the reticulated vein, which lies underneath the oral mucosa. The oral mucosa has rich blood supply and it is relatively permeable. The permeability of the buccal mucosa is 4- 1000 time greater then that of skin. the administration of drugs by the buccal route has several advantage over per oral administration such as QWICK ACTION, avoid of first pass metabolism , drug is not subject to acidic environment of the stomach and also the improved patient compliance particularly with pediatric & geriatric patient. It is the objective of this article to review the oral mucosal drug delivery by discussing briefly the structural feature of mucosa as drug delivery such as buccoadheshive film & tablet,...
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Posted by admin on May 1, 2010 in |
The chemistry of pyrimidine is a blossoming field. Numerous method for the synthesis of pyrimidine and also their diverse reactions offer enormous scope in the filed of medicinal chemistry. The utility of pyrimidines as synthon for various biologically active compounds has given impetus to these studies. The review article aims to review the work reported and the chemistry and biological activities of pyrimidines during past year....
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Posted by admin on May 1, 2010 in |
In recent years, development in science and technology has brought about significant changes to world in which we live. One such change has been the introduction of cosmetic surgery into mainstream life, having growth from being the presence of rich and famous to being an increasingly accepted option for ordinary people. Cosmetic surgery is a special branch of surgery that deals with the medical correction of person’s form and structure. Peoples have a tendency to confuse plastic surgery with cosmetic surgery, but there is actually a difference between the two. Cosmetic surgery is in fact a sub-specialty of plastic surgery and refers to surgery which is carried out purely for cosmetic purposes. The most common procedures for cosmetic surgery are discussed in the following articles. In recent years, people worldwide seem to be increasingly aware of their body image and more people are in search of the perfect body. So cosmetic surgery offers solutions to people’s problems if they feel that their own body falls short of perfection, and...
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