Posted by admin on Dec 1, 2010 in |
The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. One such problem can be solved in the novel drug delivery system by formulating “mouth dissolving tablets” (MDTs) which disintegrates or dissolves rapidly without water with in few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. Mouth dissolving tablets are advantageous particularly for pediatric, geriatric and mentally ill patients who have difficulty in swallowing conventional tablets and capsules. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for MDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research...
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Posted by admin on Dec 1, 2010 in |
Eucalyptus is a diverse genus of flowering trees and shrubs in the myrtle family, Myrtaceae. Different chemical constituents such as Sideroxylonal C, (+)-oleuropeic acid, cypellocarpins A, B and C, cypellogins A, B and C, Leptospermone, Isoleptospermone, grandinol, various essential oils and many others have been isolated from plants of eucalyptus genus. Various eucalyptus species have been reported to possess potent pharmacological actions against diabetes, hepatotoxicity, inflammation, cancer etc. This review article is presented to compile all the updated information on phytochemical and pharmacological activities of Eucalyptus species which have been performed by widely different...
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Posted by admin on Dec 1, 2010 in |
Antibiotics have a well-documented efficacy in the treatment of established infections and as prophylactic agents in medically compromised patients. Antibiotics use is suggested to be a major risk factor for development of antibiotic resistance. Resistance to antimicrobials is emerging at an alarming rate that has reduced treatment options for nearly every pathogen infecting humans. Many bacteria now display a variety of mechanisms that help protect them during antimicrobial exposure. These include production of β-lactamases and cephalosporinases, alterations in penicillin-binding proteins, multidrug efflux pumps, transferable resistance to vancomycin, and mutations in genes encoding DNA gyrase. This article gives information about how bacteria develop antibiotic resistance, new era of antimicrobial therapeutics and new strategies to eliminate antibiotic...
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Posted by admin on Nov 1, 2010 in |
Emerging nanomedicine technologies could dramatically transform medical science as we know it today with their potential to address unmet medical needs and provide targeted therapy. Nanomedicine technologies could find an increasing place in various areas and applications of the healthcare sector including drug delivery, drug discovery and development, diagnostics and medical devices. The advent of nanomedicine and techniques for the early diagnosis of diseases could usher in a new era of superior prophylactic or preventive medicine. By using preventive medicine, treatment for diseases could be initiated even before preliminary symptoms appear. Prophylactic interventions might help postpone or even avoid diseases altogether. Nanomedicine could therefore have a huge impact on people’s lives, substantially improving their physical health and quality of life. Nanocrystal technology, for instance, is being used in drug formulation and the new chemical entities screening in the discovery phase of drug development. Quantum dot particles are being applied in high-content drug screening and in the detection of breast cancer cells among others. However, as with other new technologies,...
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Posted by admin on Nov 1, 2010 in |
Wheat belongs to the genus Triticum of the grass family, Poaceae. This genus is originated in tropical South west Asia, where it occurs in wild as well as in cultivated forms. Man has depended upon the wheat plant for thousands of years. Wheat (the Triticum spp.) is cultivated worldwide. The grain production varies from year to year and hence the grains should be stored strategically from years of overproduction for the use in year of under production. Also grain must be stored for several other reasons such as point of production is not the point of consumption and the time of production is not the time of consumption. Stored grains can have losses in both quantity and quality. Grain quality after harvest is influenced by a wide variety of biotic and abiotic factors and has been studied as a stored grain ecosystem. Losses occur when the grain is attacked by microorganism and other organisms including insects, mites, rodents and birds. The grain losses found in quantity and quality; can...
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