Posted by admin on Jan 31, 2020 in |
The present investigation deals with the development of duloxetine ethosome then loading into the transdermal patch to impart lower drug side effect, enhanced bioavailability, avoiding first-pass metabolism. 32 factorial design was applied to optimize the formulation. Ethanol (X1) and Phospholipid (X2) were taken as independent variable, Responses are vesicle size (Y2), entrapment efficiency (Y1). Optimum desirability was identified and, an optimized formulation was prepared, characterized and loaded into transdermal patch. The transdermal patch was evaluated for drug content, thickness, folding endurance. Ex-vivo permeation study for the prepared patch was conducted and, the permeation parameters and drug permeation mechanism were identified. The percent of alcohol was significantly affecting all the studied responses while the other factors and their interaction effects were varied in their effects on each response. The optimized ethosomes formulation showed observed values for Y2, Y1 of 161 nm and 98.79% respectively. Ex-vivo permeation of films loaded with optimized ethosomal formulation was superior to that of the corresponding pure drug transdermal...
Read More
Posted by admin on Jan 31, 2020 in |
Morinda citrifolia (L.) is an important medicinal plant belonging to the family Rubiaceae and commonly known as “Noni” in Tamil was highly distributed in South India. The aim of this research is to understand the concept and techniques of anatomical and histochemical localization of secondary metabolites in Morinda citrifolia (L.) as well as take part in the standardization of herbal medicine. Initially the morphological observations were determined by using simple microscope. The shape of leaf, fruit, odor and type of flower were determined. The present study investigated the leaf anatomical characterization of upper and lower epidermis of Noni plant and also characterized the petiole and lamina of leaf. Finally, this study also explained the histochemical localization of various primary and secondary metabolites of stem of Morinda citrifolia was carried out with the aim of contributing to its quality control in herbal industries. The results of this study could be useful for correct identification of the plant species and also for the determination of the authenticity of the drug in...
Read More
Posted by admin on Jan 31, 2020 in |
Nanoparticles represent one of the alternatives in the treatment of cancer chemotherapy. In the present study, the prime objective was to formulate anti-cancer drug, bendamustine into polymeric chitosan nanocarrier system for its sustained release and passive targeting mechanism. Based on particle size, zeta potential and polydispersity index, F3 was selected as the optimized formulation. The SEM images revealed nanostructure with linear/rod shape enabling better internalization. The X-ray powder diffraction analysis clearly indicates reduction in crystallinity of bendamustine in nanoparticles. The nanoparticle formulation showed good results in terms of assayed drug content and encapsulation efficiency. The in-vitro permeation studies using egg membrane revealed that F3 formulation showed a sustained drug release for 28 h with an initial burst release within 1...
Read More
Posted by admin on Jan 31, 2020 in |
Escherichia coli is the predominant isolated type of bacteria in urinary tract infections in children. Multidrug resistance of this kind of infection is associated with an increased risk of kidney injury and, therefore, an increase in morbidity and mortality. This report presents a case of a 6-year-old child with recurrent pyelonephritis with multidrug-resistant E. coli. She was followed, in a teaching hospital and was successfully treated with daily cephalexin prophylaxis for about four years as a result of the collaboration of healthcare providers. Continued teamwork between health care providers, especially collaboration between the treating pediatric nephrologist and the clinical pharmacist, yielded better decisions to overcome the multidrug-resistant bacteria over the course of the disease in such a vulnerable child patient. This case lends support for the use of suppression therapy in pediatric patients with severe recurrent bladder and renal infections as well as support for the patient-centered approach in achieving improved pharmacotherapy and patient...
Read More
Posted by admin on Jan 31, 2020 in |
Inflammation, a protective response, can be dangerous if left untreated. The current synthetic anti-inflammatory drugs available in the market are coupled with various side effects. Plant-derived products can serve as a better alternative being cheap, easily available and having very few side effects. A sizable number of plants having anti-inflammatory activity have been studied. The crude extract of the plant is easy to obtain but it is not possible to indicate the component responsible for a particular property of the extract as it is a mixture of various components. Therein lays the importance of isolating the active principles from the crude extract and studying their mechanism of action. The present study aspires to provide an insight into the current trend of treatment of inflammation using herbal remedies by highlighting the different active principles obtained from different parts of plants, their concentrations used in specific test systems alongside underlining their molecular mode of...
Read More
