Posted by admin on Oct 31, 2020 in |
The imbalance between aggressive (pepsin, Hydrochloric acid) and protective elements (bicarbonate and mucosa) in the inner lining of the stomach lead to the formation of peptic ulcers. The presence of Body fluids, mucosal hydrophobicity, fast epithelial cell recharging, and rich mucosal blood flow is involved in mucosal protection of the Stomach. Prostaglandins E2 and I2 are the predominant prostaglandins which synthesized by the gastric mucosa and known to hinder the emission of gastric acid and stimulate the discharge of body fluid and bicarbonate. The treatment of peptic ulcers can either be achieved with declination in aggressive elements or elevation of mucosal resistance in the stomach and duodenum with cytoprotective agents. In this review, 30 herbal medicinal plants have been discussed along with its respective extracts; these are Bauhinea veriegata, Euphorbia umbellata, Azadirachta indica, Centella asiatica, Indigo feratinctoria, Mangofera indica, Moringa oleifera, Mimosa pudica, Aegle marmelos, Lawsonia inermis, Tephrosia purpuria, Plantago lanceolata, Solanum nigrum, Annonas quamosa, Ocimum sanctum, Morus alba, Pinusrox burghi, Allium sativum, Hibiscus cannabinus, Emblica officinalis, Curcuma longa,...
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Posted by admin on Oct 31, 2020 in |
In the proposed research paper, a simple, accurate, and precise colorimetric method has been developed for the estimation of doxycycline in bulk and pharmaceutical dosage forms. The proposed method utilizes a smartphone camera and an application instead of the UV spectrophotometer for the measurement of color intensity. This colorimetric method was found to be linear in the range of 10µg/ml to 50µg/ml concentration, with an r2 value of 0.9968. These results have been then compared with a highly selective difference spectroscopic method developed and validated by us using the principles of uncertainty. When we report the result of a measurement, it becomes obligatory that some quantitative indications of the quality of the results should also be given, which will aid in the assessment of the reliability of the results and, in turn, the method which was used to obtain those results. Without such an indication, the measurement results may not be compared, either amongst themselves or with the reference standard values. Hence, the uncertainty appraisal becomes essential to express...
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Posted by admin on Oct 31, 2020 in |
Background: Majoon hajrul yahood is a polyherbomineral formulation commonly used in the Unani system of medicine for the management of urolithiasis. In this study safety of a hydroalcoholic extract of majoon hajrul yahood was evaluate in Wistar rats. Materials and Methods: The hydroalcoholic extract of the formulation were tested for acute and sub-acute toxicity study. The single-dose (300, 2000, and 5000 mg/kg) of the extract was administered orally to female rats. In the subacute study, the extract was given at doses of 1/5, 1/10, and 1/15 mg/kg (1000, 500, and 333.33 mg/kg) of maximum dose (5000 mg/kg) of acute toxicity study during 28 days orally. Mortality, changes in body weight and food consumption, organ weights, biochemical, hematological, and histopathology of the organs were performed. Results: In the acute study, the extract was classified as safe, according to the OECD guide in category 5. In the present study, results revealed that subacute treatment with test extract, there is no changes in biochemical, hematological, and histological changes in the tissues. Conclusion:...
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Posted by admin on Oct 31, 2020 in |
Carbuncle is a serious skin disease that affects tribal communities very quickly. The disease is generally caused by Staphylococcus aureus, Escherichia coli, or Streptococcus pyogens. Due to increasing drug resistance in these bacterial strains, it has become very difficult to treat carbuncle with modern antibiotics. The information about tribal peoples using invasive weeds to treat carbuncle is empirical due to the lack of scientific validation. In this review, we focused on the antibacterial potential of invasive weeds used for the treatment of carbuncle in Purulia district of West Bengal, India. Studies by many researchers showed that those invasive weeds strongly inhibited Staphylococcus aureus, Escherichia coli, and many other pathogenic bacterial strains. So, this review work scientifically validates the use of invasive weeds for the treatment of carbuncle by tribal peoples of Purulia. This review work will also help in the discovery of new antimicrobial agents from invasive weeds and introducing them to the modern day’s...
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Posted by admin on Oct 31, 2020 in |
Amla, Arjuna, Gudmar, Guduchi, and Ginger have been usually used in the traditional system of medicine for the treatment of diabetes. The aim of the present study to evaluate antihyperglycemic activity of polyherbal and allopolyherbal formulation on Streptozotocin-Nicotinamide (STZ-NA) induced type-2 diabetes rats. All the extracts of herbs used for the present study were obtained by supercritical fluid extraction. The Oral glucose tolerance test (OGTT) and anti-hyperglycemic activities were performed on STZ-NA-induced diabetic rats. The effects of metformin, PHF, and allopolyherbal formulation (APHF) on plasma insulin, hemoglobin, liver glycogen, and glycated hemoglobin (HbA1c) were analyzed. Statistical analysis was done by using one-way ANOVA followed by Dunnett’s multiple comparison tests. The OGTT of metformin, PHF, and APHF showed increased glucose tolerance. Single-dose anti-hyperglycemic activity of metformin, PHF, and APHF showed a significant (P<0.01) decrease in blood glucose level (BGL) in diabetic rats at 1st, 3rd, 5th, and 7th h. Multiple doses anti-hyperglycemic activity of metformin, PHF, and APHF showed significantly (P<0.01) reduction of BGL in diabetic rats after 14th, 21st,...
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