Posted by admin on Sep 30, 2020 in |
Zoonoses are human diseases caused by animal pathogens or animal diseases that are transmissible to humans. They are caused by all types of pathogenic agents, including bacteria, parasites, fungi, viruses, and prions. Zoonotic diseases can be transmitted to humans by infected saliva, aerosols, contaminated urine or feces, and direct contact with the animal or pathogenic microbes. Furthermore, transmission can also occur through animal vectors (e.g., tick bite, and insects like mosquitoes or flea). The zoonotic microbes continue to evolve and adapt with tremendous acceleration and expansion of global trade, human movement, and population. Control of zoonotic diseases and protection of public health are challenging tasks as the world population is increasing proportionately. Newly emerging viruses such as the Ebola virus, severe acute respiratory syndrome (SARS)-, Middle East respiratory syndrome (MERS)-coronavirus, and the avian influenza virus, H1N1 virus, Nipah virus, Zika Virus, and now Covid-19 are serious threats to public health and have become a global concern. The prevention of these infections depends on improved diagnosis and highly effective therapeutics/...
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Posted by admin on Sep 30, 2020 in |
The work was initiated to induce a toxic model of a neurodegenerative disorder with Alzheimer’s disease symptoms in rats and to study the effect of quercetin, an anti-oxidant, and nerve growth factor on some biochemical parameters and parameters of behavioral performance of the animals. It was established that upon induction of the neurodegenerative disorder by an intranasal administration of aluminum chloride and lypo-polysaccharide, there was a decline in motor-sensor, emotional/motivation and cognitive parameters of the animals’ behavioral performance. An increase in the neutral and some fractions of glycolipids, as well as changes in phospholipid profile, were found; the activity of the antioxidant system enzymes with the MDA increase in the hippocampus of the animals was found to decrease. The deviations above in the biochemical parameters of the animals’ hippocampus seem to be a cause for the changes in the animals’ behavioral performance. Intranasal administration of the anti-oxidant and NGF in the liposomal form partially restored the parameters of the animals’ behavioral performance and the biochemical parameters to the control...
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Posted by admin on Sep 30, 2020 in |
A simple, sensitive, and rapid reverse phase High-Pressure Liquid Chromatography (HPLC) method was developed and validated for the quantification of residual Dicyclohexylurea in Fosaprepitant dimeglumine drug substance at trace level. The method was optimized on Zorbax Eclipse XDB-C8, 250 mm × 4.6 mm, 5µm with column oven temperature maintaining at 35 °C with flow rate at 0.7 ml/min. Mobile Phase was prepared by a mixture of phosphate buffer pH 7.0 (0.68 g of Potassium dihydrogen orthophosphate in 1000 ml of water) and Acetonitrile in the ratio of 53:47 v/v), the injection volume is 20 µl, the detector wavelength is 205 nm. The developed, optimized method was further validated in accordance with ICH, and the method is found to be specific, sensitive, accurate, and precise. The Limit of detection (LOD) and Limit of quantification (LOQ) for dicyclohexylurea are 20 µg/g and 60 µg/g, respectively. The method validation experimental results are discussed in detail in this research...
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Posted by admin on Sep 30, 2020 in |
At present more than 200 oral continued/controlled/ expanded/altered discharge details are accessible in the worldwide market. In India, notwithstanding, just constrained items are financially affordable. Making a stride ahead from assembling traditional dose structures, the advancement of controlled drug delivery systems. Controlled drug delivery systems have been created to improve the following arranging of the medication in the body. They can assume a noteworthy job in a focused medication conveyance framework in organ or tissue. In the Controlled medication conveyance framework, more than one instrument might be included at various phases of medication pharmacokinetics and pharmacodynamics profiling. Some medication conveyance frameworks have been planned and are being researched. These sorts of the context had some bit of leeway over common medication conveyance framework, including a brief time of medication discharge insurance of flimsy medications and expanded patient solace and consistency. The audit underlines the technique of controlled medication conveyance framework planning, their criticalness, burdens, point by point order, and the pertinent model any place required are illustrated. This audit...
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Posted by admin on Sep 30, 2020 in |
Merremia emarginata is a creeping herb, rooting at nodes, and commonly used in folk medicine. The current study was undertaken with the aim of preliminary phytochemical analyses, evaluation of antimicrobial activity, and antioxidant activity by methanol and aqueous extracts of leaves of Merremia emarginata. The extracts were subjected to preliminary phytochemical analyses; Antibacterial activities against nine bacterial strains were done by using agar – well diffusion method and free radical DPPH antioxidant activity. Preliminary phytochemical analyses were done by using standard phytochemical methods that showed the presence of Carbohydrates, reducing sugars, phytosterols, fixed oils, saponins, phenolic compounds and flavonoids. Based on the results of phytochemical analyses, methanol and aqueous extracts of the plant were chosen for antibacterial studies. Methanolic extract of leaves showed the highest antibacterial activity followed by the aqueous extract. The present study indicates that the leaves of Merremia emarginata possess antibacterial activity and found effective against eight bacterial cultures. Antioxidant activity of the DPPH assay showed that extracts exhibit the scavenging effect of various...
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