Posted by admin on Aug 31, 2020 in |
Diabetes mellitus (DM) is a globally spreading metabolic disorder with a high incidence rate. About 425 million cases took place in 2017 and expected to rise up to 693 million by 2045. In diabetes, the patient elevation of blood glucose level occurs due to the deformation of insulin receptor action/secretion or both. Long term increases in blood glucose level causes chronic effects such as dysfunction and damage of various organs such as eyes, nerves, kidney heart and blood vessels. There are many treatment regimens available in market, but do not able to provide complete relief and cause severe side effects. To overcome these types of problems it becomes important to find different therapeutic targets and use it in combination with conventional medicine for the treatment of diabetes. To surmount the side effect of presently available treatments, now researchers relay on herbal plants. In this review, we discussed the diabetes occurrence, epidemiology, types, different target receptors, and available treatments and describe briefly role of different plant constituents in diabetes management...
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Posted by admin on Aug 31, 2020 in |
The aim of the present research work was to develop a bilayer floating dosage form of immediate-release Atorvastatin (ATR) and sustained release Captopril (CPT) in matrix form for the treatment of hyperlipidaemia and hypertension to reduce multiple dosing frequencies and enhance patient compliance. ATR belongs to the BCS Class II category having poor aqueous solubility, which was enhanced by using hydrophilic polymer PEG 8000 by kneading technique. A sustained layer of CPT was prepared by melt granulation technique using various concentrations of carnauba wax with HPMC K 100 M and Carbopol 934 P. All the parameters before and after compression were evaluated. ATR-PEG ratio of 1:0.25 showed a higher drug release of about 97.42% within 60 min. The optimized CPT sustained layer SR2 shown the highest drug release 98.2% in 12 h. In-vitro drug release studies carried out as per USP in pH 1.2 buffer using type II apparatus. The CPT layer exhibited release kinetics in the first order and followed the diffusion and erosion mechanism. The FTIR, XRD...
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Posted by admin on Aug 31, 2020 in |
Multidrug-resistant (MDR) bacterial infection is severe health concerns in the field of medicine. The researcher used green synthesized silver nanoparticles to overcome from MDR bacterial infection. Present study revealed successful synthesis of nanoparticles from Curcuma caesia aqueous rhizome extract by use of silver metal as a capping agent. Synthesized silver nanoparticles were identified by various methods like UV-Vis spectroscopy, Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and Scanning electron microscope (SEM). Silver nanoparticles having an average size of 31.92 ± 2.8 nm by TEM. The synthesized silver nanoparticles were discovered as an effective source of nanomedicine against MDR strains of Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa. The antibacterial activity of nanoparticles measured in the range from 11.4 ± 0.83 mm to 17.73 ± 0.91 mm. The highest zone of inhibition was reported against Pseudomonas aeruginosa i.e., 17.73 ± 0.91 mm at a concentration of 30 μg/μl. Silver nanoparticles showed increased total phenolic and total flavonoid content, additionally with higher DPPH activity as compared to the aqueous rhizome extract. Present...
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Posted by admin on Aug 31, 2020 in |
The present study has been undertaken to evaluate the association between serum uric acid levels as a marker of iron overload in Saudi people. A retrospective cohort study was carried out at King Fahad Medical City in the Riyadh-central region of the Kingdom of Saudi Arabia for four months from 1st November 2018 to the end of February 2019 on the random sample of 117 medical files for Saudi patient of both genders. All the obtained data were analyzed by the SPSS program by considering various variables like serum uric acid, transferrin, hemoglobin, ferritin level, etc., in between hyperuricemic non-hyperuricemic patients. Serum uric acid, transferrin, ferritin, and hemoglobin levels were significantly (p>0.05) high i.e. 564.1 ± 127.7 vs. 417.6 ± 38.3 μmol/l; 3 ± 1 vs. 2.1 ± 0.8 g/dl; 658.9 ± 896 vs. 528.6 ± 920 ng/ml; 9.9 ± 2.2 vs. 9.7 ± 1.8 g/dl in hyperuricemic and non-hyperuricemic patients respectively. Pearson correlation between serum uric acid and hemoglobin, ferritin level, transferrin level indicate positive correlation (r =...
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Posted by admin on Aug 31, 2020 in |
Herbal medicines play an important role in cancer prevention. Mangroves have been used worldwide due to the presence of various bioactive metabolites in it. The specific medicinal properties of Rhizophora mucronata have been an interest in preventing breast cancer. Mangroves Rhizophora mucronata belongs to family Rhizophoraceae. The leaf extract reveals various roles in folk remedies to treat various diseases. This analytical study aims to find out various phytochemical and components present in the leaf extract by the GC-MS technique. The methanol leaf extract revealed the presence of phytochemicals like saponins, flavonoids, alkaloids, quinines, glycosides, cardiac glycosides, terpenoids, phenols, coumarins, and steroids. The GC-MS analysis provided nine different compounds like Phenol, 2, 4-bis (1,1-dimethyl ethyl)- (28.2%), Flavone- (66.9%), 4H-1-benz0pyran-4-one,7-hydroxy-2phenyl (39.8%), Chrysin (100%), 4H-1 Benzopyram-4-one, 7-hydroxy-2-phenyl-(100%), 5,8 Octadecadienoicacid, methyl ester-(55.8%), Phytol- (31.8%), Coumarine, 3-(2,4-dinitrophenyl)-(31.3%), Elaidic acid, isopropyl ester-(9.2%). Further purified compounds are used in the pharmacological industry against breast cancer and reduce the side effects and pains during the treatment of...
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