Posted by admin on Nov 30, 2020 in |
Objective: To study the in-vitro antioxidant as well as nephroprotective potentials of Crinum asiaticum bulbs’ethanolic extract in contrast to gentamicin-induced nephrotoxicity in albino rats. Materials and Methods: The ethanolic extract of Crinum asiaticum bulbs subjected to preliminary phytochemical analysis to determine the phytoconstituents and evaluation of antioxidant activity was done using in-vitro methods like DPPH as well as lipid peroxidation assays using ascorbic acid as standard. In-vivo nephroprotective activity was estimated by utilising gentamicin induced nephrotoxicity in albino rats. Results: It was revealed by the preliminary phytochemical analysis that phenolics, tannins, steroids, terpenoids, and flavonoids components are presented. The promising results obtained by in-vitro antioxidant activity promoted us to evaluate gentamicin induced nephrotoxicity in rats. Gentamicin impeded nephrotoxicity in rats as proved by extremely substantial (p<0.001) rise of blood urea, serum creatinine and uricacid in Group II in comparison to Group I. Also, administration of Gentamicin in group II caused oxidative stress in rats proposed by considerable increase in LPO level as well as considerable decrease in GSH level....
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Posted by admin on Nov 30, 2020 in |
Eclipta alba (Family-Asteraceae) is a herb commonly used in traditional Ayurvedic medicine for the treatment of inflammation, pain, and wounds. The present study is aimed to validate the ethnobotanical use of Eclipta alba in an animal model. The animals were induced with arthritis by injection of FCA on day 0 and treated with wedelolactone rich fractions of Eclipta alba (100, 200 and 400 mg/kg) from day 12 to day 28. WEA caused a significant effect in arthritis by inhibiting the joint inflammation and decreasing hyperalgesia and allodynia. WEA significantly decreased the biochemical markers and serum Tumor Necrosis factor-α, Interleukin 1β and Interleukin-6 levels and significantly increased the antioxidant profile. WEA (400 mg/kg) exhibited anti-rheumatic activity as evidenced by altered hematological milieu (ESR, CRP, WBC, RBC and Hb), histopathology of ankle joints, reduced cytokine levels, paw volume and related parameters associated with arthritis. Taken together, these results demonstrated the antiarthritic activity of WEA against experimental arthritis, and the underlying mechanism behind this efficacy might be mediated by inhibition of proinflammatory...
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Posted by admin on Nov 30, 2020 in |
The objectives of the present investigation were to formulate and evaluate of Medicated oral jelly containing Trazadone HCl for the treatment of depression. Many psychotic patients are medicinal phobic who are afraid of taking medicine, so this preparation is most beneficial over that type of fear. Trazadone HCl antidepressant drugs incorporate in jelly and give to those patients; in this way, we could administer medicine to them without bringing this to their attention. Jellies are prepared by heating and congealing methods by dispersing gelling agents in water and evaluated for their physicochemical parameters like appearance, stickiness, pH, viscosity, Spreadability, stability studies, drug release, and content uniformity. All batches (F1-F8) of medicated jelly showed acceptable and comparable appearance, pH, viscosity, Spreadability, stability studies, drug release, and content uniformity. The viscosity range was found to be 53305 to 61731cps. The drug content of F1 to F8 formulations was found to be in the range of 88.42 to 98.95%. F7 batch prepared with gelatin + xanthan gum combination shows 98.95%. drug...
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Posted by admin on Nov 30, 2020 in |
The aim of the present study was to investigate the effect of Curcumin on blood glucose levels, body weight changes, and oxidative stress markers in the diabetic rat liver. Diabetes exacerbates hepatic injury induced by hyperglycemia mediated oxidative stress. A marked decrease in the blood glucose levels, body weight changes and anti-oxidant marker enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and increase in malondialdehyde (MDA) was observed in the diabetic rats. Decreased activities of antioxidant enzymes and body weights in diabetic rats were augmented on the oral administration of Curcumin. Moreover, Curcumin administration depleted the MDA level, which was earlier increased in the diabetic rats. These results suggest that Curcumin exhibits a hepatoprotective effect by accelerating hepatic anti-oxidant defense mechanisms and downregulating the MDA levels to the normal levels in the diabetic rats. Thus, Curcumin may be used as a therapeutic agent in preventing complications in diabetic...
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Posted by admin on Nov 30, 2020 in |
During the present investigations attempt was made to the green synthesis of silver nanoparticles using root extract of Aerva tomentosa Forsk. and to analyze its antibacterial and antioxidant activities. Exposure of the root extract of Aerva tomentosa to aqueous AgNO3 resulted in the formation of silver nanoparticles. The synthesis of silver nanoparticles was confirmed by UV-Vis spectrophotometer and was characterized by X-ray diffractometer. The bactericidal activity of silver nanoparticles against Escherichia coli, Bacillus thuringiensis, Bacillus subtilis and Pseudomonas putida was determined using bacterial growth inhibition method. The antioxidant study of silver nanopartcles was analyzed by the 2, 2-diphenyl-1-picrylhydrazil (DPPH) radical scavenging method. The synthesis of AgNPs via this green approach by Aerva tomentosa root extract were average size particles and crystalline in nature. The synthesized silver nanoparticles with two concentrations (0.01g/100µl) and (0.005g/100µl) exhibited high antibacterial activity in terms of maximum zone of inhibition against Escherichia coli, Bacillus thuringiensis, Bacillus subtilis, and Pseudomonas putida. Silver nanoparticles also showed significant antioxidant activity. There was a dose-dependent increase in the percent antioxidant activity...
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