Posted by admin on Jul 31, 2020 in |
The ethanolic extract of Terminalia chebula extract obtained from successive extraction of Rosa damascene by Methanol; n-hexane & n-butanol was subjected to various phytochemical tests. The antioxidant activity was accessed by DPPH method. The anti-Parkinson’s activity was tested in albino Rats. Thirty albino rats (180-250 g) of either sex were divided into five groups and each group consist of six animal (n = 6). Group I: Normal Control (received 0.9% normal Saline) Group II: Disease control (Received Haloperidol 2 mg/kg i.p. single dose for 11 days). Group III: (Received Haloperidol 2 mg/kg i.p. single dose for 11 days) treated with standard drug Levodopa 6 mg/kg p.o continued for the next 45 days. Group IV: (Received Haloperidol 2 mg/kg i.p for 11 days) treated with polyherbal (Terminalia chebula & Rosa damascena) suspension at dose of 100 mg/kg p.o for next 45 days. Group V: (Received Haloperidol 2 mg/kg i.p for 11 days) treated with polyherbal (Terminalia chebula & Rosa damascena) suspension at 200 mg/kg p.o for next 45 days. After...
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Posted by admin on Jul 31, 2020 in |
In today’s 21st century, Carbon nanotubes (CNTs) are the most researched material by world investigation of the growing industry due to their various reasons properties for use in many applications either in medical or other potential applications. Carbon nanotubes become increasingly popular in various fields simply because of their small size and amazing optical, electric, and magnetic properties when used alone or with additions of metals. Carbon nanotubes are described as a cylindrical rolled graphene sheet. They are cap with end containing the pentagonal ring and also cylindrical of graphene with a diameter of 12 nm. Carbon nanotubes have potential therapeutic applications in various fields like drug delivery for API, diagnostics, and biosensing. Functionalized carbon nanotubes can also act as vaccine delivery systems. The basic principle involved in this to link the antigen to carbon nanotubes while retaining its conformation, thereby inducing antibody response with the right specificity. With the increasing interest shown by the nanotechnology research community during this field, it’s expected that a lot of applications of...
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Posted by admin on Jul 31, 2020 in |
Three different species of seaweeds collected from south east coast of India such as Sargassum plagiophyllum, Padina gymnospora and Turbinaria conoides for evaluating anti-bacterial activity against selected gram-positive and gram-negative bacteria. Extracts prepared using solvents namely hexane, ethyl acetate, methanol, and water against human pathogenic strains of Proteus vulgaris, Staphylococcus aureus, Klebsiella pneumonia, Enterobacter aerogenes, Salmonella typhimurium, Yersinia pestis, Shigella fiexneri, Staphylococcus epidermidis and Bacillus subtilis. Gram-negative bacteria showed a lesser zone of inhibition than gram-positive bacteria with various extracts tested. All the three solvent extracts of Turbinaria conoides showed, zone of inhibition for the gram-positive bacteria, Staphylococcus epidermidis over the standard control, with a significant zone in hexane extract. Analysis of GC-MS of Turbinaria conoides hexane extract revealed 14 major and numerous minor phytochemical compounds that have to be fractionated and explored for specific anti-bacterial activity in order to isolate a potential anti-bacterial...
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Posted by admin on Jul 31, 2020 in |
Liver fibrosis is a wound healing process that is initiated in response to chronic liver injury caused by viruses, toxins, and hepatotoxic drugs. This disease is characterized by inflammation, followed by the deposition of extracellular matrix proteins to form scar tissue. Ephrin receptor A2 (EphA2) is identified as a host cofactor for Hepatitis C Virus (HCV) entry. The fruits of Solanum nigrum possess anti-inflammatory properties. The present work was done to evaluate the anti-inflammatory activity of the ethanolic fruit extract of Solanum nigrum against EphA2 receptor using Induced fit docking of Schrödinger software. Phyto-compounds were retrieved from the PubChem database. The 3D structure of EphA2 was downloaded from Protein Data Bank (PDB). Among the five phytocompounds, Ethyl caffeate has the Glide Score of -8.01 and glide energy-35.48 kcal/mol. From the results, it is evident that the phytoconstituents of Solanum nigrum fruits have anti-inflammatory potential and prevent hepatic fibrosis. Molecular properties of the compounds were predicted using the Molinspiration tool, and the pharmaco-kinetic properties of the compounds were predicted using...
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Posted by admin on Jul 31, 2020 in |
The current study work is focused on Dapoxetine hydrochloride buccal films. In recent days, buccal drug delivery has aimed at importance in many aspects compared to conventional tablets. The addition of mucoadhesive polymers to the formulation enhances the therapeutic levels of drug. Dapoxetine hydrochloride, a choice of drug used in the therapy of premature ejaculation in men. Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI’s) whose oral bioavailability is 42% due to hepatic first-pass metabolism. To enhance the bio-availability and drug release, Dapoxetine hydrochloride is designed as buccal films. They are prepared by the most commonly used solvent-casting method. Two grades of Hypromellose (E15 and 5cps), polyvinyl alcohol, and polyvinyl pyrrolidine are polymers that are mucoadhesive in nature. Propylene glycol is used as a plasticizer, and also mucoadhesive polymer and methanol as a solvent are used in film preparation. FTIR studies were done, and there is no incompatibility between active pharmaceutical ingredient (API) and excipients. The formulations developed were evaluated for different parameters such as weight uniformity, thickness,...
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