Posted by admin on Jun 30, 2020 in |
Phymatosorus scolopendria (Burm. F.) Pic. Serm. belongs to the family Polypodiaceae which is commonly known as musk-fern or wart-fern. Medicinally, the experimental plant possesses insect repellent, anti-inflammatory and bronchodilator activity and hence used ethnomedicinally by tribal people, but was not explored for its bioactive compounds. Hence, the objective of this study was to determine the bioactive compounds present in the methanolic extract of Phymatosorus scolopendria by Gas Chromatography-Mass Spectrum. The methanolic extract of the experimental plant revealed the presence of four phytoconstituents, namely dodecanoic acid, 1,2,3-propanetriyl ester, myristic acid vinyl ester, 4-nitrophenyl laurate and hexadecanoic acid, 4-nitrophenyl ester with peak values 8.98, 53.29, 26.91 & 10.82. The predicted biological activities for the present compounds identified when referred in the literature shows antioxidant, antibacterial, antiviral, candidicidal, hypocholestrolemic, antiarthritic, hepatoprotective, mosquito repellent, antimicrobial, anticancer and cosmetics. The compounds were identified by comparing their retention time and peak area with that of literature and interpretation of mass spectra. The research could be continued to find out the therapeutic importance of all the...
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Posted by admin on Jun 30, 2020 in |
New complexes of La (III) and Nd (III) with bidentate Schiff base ligands, 1-H indole-(2, 3-dione) hydrazinecarbothioamide (L1H), 1-H indole-(2, 3-dione) hydrazinecarboxamide (L2H) have been synthesized and characterised. The stoichiometry of the complexes is originated in the type of [Ln (L1, 2) 3].3H2O for both metals. The characterization and nature of bonding of these complexes were elucidated by elemental analysis, melting point, molecular weight determinations, electronic spectra, redox behavior, magnetic and EPR studies, IR, 1H and 13C NMR spectral studies. From an elemental analysis, the complexes are in 1:3 (metal: ligand). Whole studies propose non-electrolytic behaviour and an octahedral geometry of Ln (III) complexes. La (III) and Nd (III) metal complexes and their parent ligands tested antimicrobial potency in-vitro, and the result indicates that metal complexes are more active than parent...
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Posted by admin on Jun 30, 2020 in |
Simultaneous estimation of parent and its metabolite(s) in a single method poses a threat when one has to monitor one mass transition while running the other compound on liquid chromatography-mass spectrometer. This would again become critical once interference is observed at the retention time of compound of interest in-spite of its absence in the sample. In this paper, a selective and sensitive liquid chromatography-tandem mass spectrometry method for the simultaneous determination of Raloxifene and its two active metabolites, Raloxifene 4-Glucuronide and Raloxifene 6-Glucuronide in human plasma was developed and validated. The method involves a rapid solid-phase extraction from plasma, followed by reversed-phase chromatography with gradient flow condition and mass spectrometry detection. Validation parameters were selected ranging from 0.016 to 1.187 ng/mL for Raloxifene, 3.073 to 700.558 ng/mL Raloxifene 4-Glucuronide and 0.311 to 124.526 ng/ml for Raloxifene 6-Glucuronide. The mean recovery for Raloxifene, Raloxifene 4-Glucuronide, and Raloxifene 6-Glucuronide found to be 85.10, 86.30 & 87.20%, respectively. The peak concentration of Raloxifene, Raloxifene 4-Glucuronide, and Raloxifene 6-Glucuronide were 0.330 ng/mL, 153.047...
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Posted by admin on Jun 30, 2020 in |
Cancer is a genetic disorder that results from genetic or epigenetic alterations in the somatic cells and has abnormal cell growth which may be spread to other body parts. In 2018, 18 million cancer was recorded globally in which 9.5 million cancer cases in men, 8.5 million cases in women, and 9.6 deaths were also recorded in the same year. The most spreading cancer globally is prostate, breast, lung stomach, colorectal cancer, non-melanoma skin malignancies but there are 100 types of cancers that affect humans. The impact of cancer is increasing significantly day by day. Tobacco is 22% responsible for causing cancer, 15% cancer is caused due some infections like HIV, hepatitis b, Epstein-Barretc, and 10% is due to poor diet, obesity, excessive consumption of alcohol, exposure to ionizing radiation, etc. In this review article, we try to shed a light on various cancer-causing factors, type of cancer, how the cancer starts, sign or symptom of cancer, diagnosing tests, the treatments of cancer and problems related to cancer treatments....
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Posted by admin on Jun 30, 2020 in |
A rapid, fast, accurate, and precise method was developed for the estimation of lenvatinib in human plasma using methotrexate as an internal standard by reverse-phase high-performance liquid chromate-graphy (RP-HPLC). The separation was carried out by using zodiasil C18 (150 × 4.6 mm, 5 m) as a stationary phase and 0.01 N sodium di-hydrogen phosphate (pH: 4.8): acetonitrile in the ratio of 45:55 % v/v. The analysis was performed at a flow rate of 1.0 ml/min using PDA detector at 240 nm. The column temperature was maintained at 30 °C for better separation and resolution. The retention time of lenvatinib was found to be 4.508 min. The % coefficient of variation of lenvatinib was found to be 2.66%. The % recovery was found to be 94.758%. The method was found to be linear between the concentration range of 28-1120 ng/mL (r2 = 0.999). The lower limits of quantification were 28 ng/mL, which reach the level drug possibly found in human plasma. Further, the reported method was validated as per the...
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