Posted by admin on Nov 30, 2020 in |
Highly bioactive ultra-small vancomycin doped silver nanoparticles were synthesized by the sol-gel method. The samples were characterized by UV, FR-IR, XRD, Photoluminescence, and TEM analysis. Continuous stirring helped in preparing ultra-small drug conjugate silver nanoparticles. Observation of weak (broadened peak) in XRD diffractograms indicates the formation of very small size drug conjugate sliver nanoparticles. Doping of Vancomycin drug improves the antibacterial activities of silver nanoparticles in the serial dilution method and results in strong yellow, green, and blue luminescence peaks. Antibacterial assay showed that sliver nanoparticles conjugation with vancomycin drug enhanced the antibacterial activity against a variety of gram-positive bacteria like E. coli, S. aureus, and Enterococcus faecalis. These findings suggest that modifying clinically approved drugs using nanotechnology is a feasible approach in our work for effective antibacterial molecules. The results of this study revealed that the potential therapeutic applications of silver nanoparticles in combination with vancomycin antibiotic had been increased drastically. Nanosilver with antibiotic is a promising candidate for the development of future antibacterial therapies because of its...
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Posted by admin on Nov 30, 2020 in |
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in edible plants. Chalcone metal complexes and their derivatives have been known over the past fifty years. Copper is an essential element, and hence it is used to synthesize metal complexes. Copper possesses a broad spectrum of activity and a higher DNA binding ability when compared to platinum drugs. The metal-based drugs may range from natural products to artificial organic molecules. Their exceptional magnetic optical radioactive are used in many non-invasive methods like magnetic resonance imaging (MRI), position emission tomography (PET), optical imaging. Copper-based metal complexes have been studied extensively towards DNA interaction aspects. The binding ability of the complexes has been explored based on the results of DNA binding studies assessed by different spectroscopic techniques like UV absorption titration. Thus, we are reporting DNA interaction studies using UV spectroscopic...
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Posted by admin on Nov 30, 2020 in |
Osmotic tablets have emerged as a new technology for the delivery of drugs whose release rate is to be controlled. These tablets offer controlled drug release with the help of certain osmogens and also provide zero-order rate kinetics. In the present study, we have developed an osmotic tablet of Metformin Hydrochloride (HCL) to enhance its oral bioavailability. Metformin HCL is a biguanide derivative often used as an anti-hyperglycemic agent. The tablets were prepared using the wet granulation technique. The prepared formulations were characterized and optimized on the basis of various physicochemical properties, and F5 was selected as best. The in vitro drug release study demonstrated that the drug release depends upon the concentration of different polymers, including hydroxyl propyl methylcellulose (HPMC) and Poly ox N80 (polyethylene oxide). A higher concentration of HPMC and Poly ox N80 results in drug release for extended duration. The optimized formulation developed with a 3:1 ratio of both the polymers HPMC E5 and Poly ox N80 have shown nearly 86% of drug release. Osmotic...
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Posted by admin on Nov 30, 2020 in |
In Today’s world, there are many drug delivery systems available but there are many problems related to drug delivery systems like stability, degradation in-vivo. Drug delivery through tablets is the most convenient method due to patient compliance. Recently, hydrogels are hydrophilic 3-dimensional polymeric structures that have been explored by researchers due to their extraordinary promising potential in a wide range of applications such as drug delivery, sealing, and tissue engineering. These 3-D polymer networks with the ability of shape deformations show a volume phase transition. The polymers used in the formulation of hydrogel have low mechanical strength and difficult to handle. Shape memory hydrogels have been extensively explored and probed; however, no amalgamated information on their effective utilization in biomedical applications is available as such. In this review article, we systematically consolidate prevailing literature and briefly enumerate shape memory hydrogels based on their principles as well as their shape transitions in diverse environments, which significantly affects operational exploitations of shape memory...
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Posted by admin on Nov 30, 2020 in |
Solanum torvum Sw. belonging to the family Solanaceae is locally called as pea eggplant, sundai and cherry egg-plant in India. The fruits of Solanum torvum Sw. used to cure diseases of the diuretic, malaria, stomach aches, problems with the spleen, treat coughs, improve the eyesight, treats headaches which attribute many properties in Ayurveda, siddha, unani and local health traditions. The purpose of this study is to isolate and characterize the STL, STB and STD from the fruits of Solanum torvum Sw. The isolation was done using column chromatography using gradient elution with different mobile phase. Structural elucidation of the isolated compounds was established out on the basis of elemental analysis and spectroscopic evidence of IR, 1H NMR, 13C NMR spectra. The purification of the isolated compounds by HPLC and HPTLC was carried out. On the basis of the spectral data and chemical reactions, the compounds have been established as STL, STB, and STD are being reported from this plant for the first...
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