Posted by admin on Apr 30, 2020 in |
Allmania nodiflora (L.) R. Br. is a diffuse herb, belongs to family Amaranthaceae. Fresh leaves used as a green leafy vegetable, which is rich in vitamins and iron. The present aim of this work is to evaluate the phytochemical composition and antioxidant activity of ethanol and water extracts of A. nodiflora leaves. The results on the phytochemical composition of the water and ethanol extracts of A. nodiflora revealed that water extract showed a higher amount of total phenolic (TPC) and total flavonoid (TFC) contents than ethanol extract. Regarding antioxidant activity results, both water and ethanol extracts showed a higher amount of total antioxidant capacity (TAC) and dose-dependent activity against the DPPH, hydroxyl radical and lipid peroxidation activity. In conclusion, the water extract of A. nodiflora leaves showed a high amount of TPC, TFC and TAC and strongly inhibited DPPH, hydroxyl radical and ferric chloride-induced lipid peroxidation in goat liver tissue homogenate. The findings of the study suggest that A. nodiflora leaves could be used as a potential source of...
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Posted by admin on Apr 30, 2020 in |
Objective: The present work deals with the statistical optimization of memantine hydrochloride orally disintegrating tablets by the design of experimentation. The study was aimed at the development of a stable and robust formulation for the well-being of society for the treatment of Alzheimer’s disease, which is the most common form of dementia. Methods: Binder (X1), disintegrant (X2), and diluent (X3) concentrations were selected as independent variables, and their levels were optimized by employing a Central composite design, whereas dissolution (Y1) and disintegration time (Y2) were selected as the dependent variables. Results: All formulations were evaluated for physical parameters of lubricated blend and compressed tablets. Mathematical equations and response surface plots were used to relate the dependent and independent variables. The regression equation generated for dissolution was Y1 = 93.51 – 7.00B + 5.20C – 4.28B² – 2.28C² and for disintegration time (DT) was Y2 = 4.80 + 0.0148A + 0.3690B -0.3181C. Conclusion: The statistical significance of each variable with respect to the model was established, and optimized formulation factors...
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Posted by admin on Apr 30, 2020 in |
The present study is undertaken with an aim to improve the dissolution profile and availability of a poorly soluble drug, Lornoxicam, through the development of liquisolid tablets. Liquisolid compacts were prepared by employing PEG 400, Avicel PH 112, and Aerosil 200 as solvent, carrier and coating materials, respectively. The flow properties of the drug improved significantly after formulating it into the liquisolid compacts. The post-compressional parameters of prepared tablets revealed the uniformity and maintenance of standards within the different batches. In-vitro drug release studies showed significant improvement in the dissolution of lornoxicam in its liquisolid form compared to a commercial product. The effect of formulation parameters, such as drug concentration and carrier to coat ratio, on enhancing drug dissolution, was also explored. FT-IR, DSC and XRD techniques were employed for the physical characterization of the drug in the liquisolid systems. The drug release from the optimized liquisolid compacts (F8) followed first-order release...
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Posted by admin on Apr 30, 2020 in |
The worsening trend of anemia in pregnancy continues to be a cause for concern in many developing countries. There is a need for synergy involving all health care professionals in order to reverse this alarming trend. The objective of this study was to assess the impact of pharmacists initiated health education intervention on anemia in pregnancy in the rural setting, in Kano, Nigeria. A total of 280 pregnant women attending an antenatal clinic, 140 each from the test and control sites, were recruited by a systematic sampling technique after signing a written informed consent form. A pre-tested interviewer-administered questionnaire was used to elicit baseline demographic and obstetric information. Baseline Packed Cell Volume (PCV) was done for each group, using the capillary technique. Health education intervention was administered to the test group only. Baseline and Post-intervention PCV were compared after 8 weeks using Chi-square statistics. A p-value of less than 0.05 was considered significant. The baseline prevalence of anemia was quite high, 31.4% and 39.3% for test and control groups respectively. There...
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Posted by admin on Apr 30, 2020 in |
The study aimed to investigate and characterize the antioxidant compounds from the leaves and barks of Dillenia scabrella (Dilleniaceae) (D. scabrella), an indigenous plant in the Northeast. The air-dried leaves and barks were powdered and subjected to selective sequential extraction using solvents of increasing polarity through percolation, namely, methanol, ethyl acetate + ethanol and water to obtain three different extracts. Further, the antioxidant potential of each of the extracts was checked by DPPH (1, 1-diphenyl, 2-picryl hydrazyl) assay. It was followed by preliminary phytochemical tests and gas chromatography-mass spectrometry to identify the anti-oxidant compound. All 4 crude extracts have shown significant antioxidant activity. The methanol extract of leaves (93%) at 500 µg/ml and bark (93.48% and 93.42%) at 500 µg/ml and 400 µg/ml showed free radical scavenging activity which was greater than the standard ascorbic acid (92.5%). In the phytochemical tests, phenolics were invariably present in all 4 extracts. Qualitative determination of the different biologically active compounds from crude extracts of D. scabrella using gas chromatography-mass spectrometry revealed different...
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