Posted by admin on Nov 30, 2021 in |
Psoriasis is a chronic inflammatory skin disease characterized by red, scaly and raised patches, and it has affected nearly 2-3% of the population worldwide. This skin disorder occurs when the immune system sends faulty signals that result in the speeding up of the skin cell cycle. Psoriasis is histologically characterized by marked hyperproliferation of keratinocytes, neutrophils, and a dense inflammatory infiltrate of T cells. Vascular dilation and proliferation are also observed. The primary defect in psoriasis patients was believed to be an abnormal epidermal cell proliferation. Psoriatic skin exhibits an advanced state of lipid peroxidation. It has been suggested that antioxidant treatment can help in the management of the disorder. Literature indicates that polyphenolic compounds found in plants have a positive effect on many chronic diseases. Natural polyphenols, recognized as potent antioxidants, are multi-functional molecules that can act as anti-inflammatory and antiproliferative agents through the modulation of multiple signalling pathways. This characteristic could be advantageous for the treatment of multi-causal diseases, such as psoriasis. Genistein is one of such...
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Posted by admin on Nov 30, 2021 in |
Natural products offer great hope in the identification of bioactive compounds and their development into drugs for the treatment of various diseases. The present study aims to evaluate the antioxidant potential of Portunus pelagicus. P. pelagicus (Station-I) possessed 33.14% of inhibition, the highest DPPH activity, whereas Station II and Station III showed 31.42% and 30.85% of inhibition. Portunus pelagicus possessed 3.34% reducing ability at 1000 µg/ml concentration in the present study in station I, station II exhibited 2.62%, and station III shpwed2.55% at 1000 µg/ml concentration. The highest reducing ability was recorded at the station I, compared to stations II and III. The present study revealed that the tissue extract of Portunus pelagicus has antioxidant capacity, and it needs further characterization to improve the pharmacologically active marine natural...
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Posted by admin on Nov 30, 2021 in |
A nafion plus functionalized-multiwalled carbon nanotubes modified glassy carbon electrode (f-MWCNTs/GCE) was developed for the determination of anti-depressant drug mirtazapine (MIR). The electro-chemical behavior of the molecule was investigated employing cyclic voltammetry (CV), chronocoulometry (CC), and differential pulse adsorptive stripping voltammetry (DPASV). The surface morphology of the electrodes has been studied through scanning electron microscopy (SEM). These studies revealed that the oxidation of MIR is facilitated at f-MWCNTs/GCE. After optimization of analytical conditions employing this electrode at pH 10.5 of 0.04M carbonate buffer for MIR, the peak currents were found to be linearly with different concentrations in the range of 6.72 × 10-6 M to 3.74 × 10-4 M for MIR. The detection limits were obtained of 32.45 × 10-8 M and 9.45 × 10-7 M for MIR, using DP-AAdSV. The prepared modified electrode has several advantages, such as simple in preparation method, showed high sensitivity with very low detection limits, and gave excellent reproducibility. The proposed method was also employed for the determination of MIR in pharmaceutical formulations,...
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Posted by admin on Nov 30, 2021 in |
In pharmaceutical research, the transdermal route of drug delivery has gained great interest, Trasferosomes is a novel vesicular drug carrier system that is composed of water, surfactant, and phospholipids; these were introduced in the early 1990s. The mechanism on which drugs absorb through skin is “osmotic gradient”. Transferosomes, when applied on the skin surface it diffuses into skin layers and provides smoothness and hydration to the skin, which facilitates drug absorption. The transferosomal gel of ketoconazole was prepared with the aim to achieve higher diffusion through the skin for the treatment of acne with minimum or no side effects. The formulations were prepared by the reverse-phase evaporation method. Formulations were prepared by varying the ratio of soya lecithin and cholesterol by maintaining room...
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Posted by admin on Nov 30, 2021 in |
Oral administration of drugs is considered a convenient route; however, various drugs that are insoluble in water or cannot permeate across gastrointestinal tract membrane cannot be delivered by this route. To enhance the permeability through the physiological barriers, lipophilic drugs are introduced but, lipophilic drugs have low oral bioavailability. To enhance the bioavailability, a third-generation lipid matrix was introduced as nanostructured lipid carriers (NLCs), which are a mixture of solid lipids mixed with some incompatible liquid-lipids. NLCs have been reported to be an alternative system to emulsions, liposomes, microparticles, solid-lipid nanoparticles (SLNs). This article mainly focuses on the types and methods of preparation, advantages, the applicability of NLCs in the present and in the near...
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