Posted by admin on Feb 28, 2021 in |
Department of Botany, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, conducted a pot culture experiment for analyzing the effect of bio-composted groundnut shell and vegetable waste on the growth impact of Pigeon pea (Cajanus cajan (L.) Mill sp. Organic wastes and by-products are renewable forms of resources generated all over the world. The present work explores the potential application of eco-friendly compost from groundnut shell and vegetable wastes. The study mainly deals with the physicochemical properties of raw and composted vegetables and groundnut shell Waste, pH and Electric conductivity, Lignin, Total Nitrogen (N), Total Phosphorous (P), Total Potassium (K), and C: N ratio. Composting was carried out with the help of Trichoderma asperelloides, Pleurotus florida, and Eudrilus eugeniae. The experiments consist of four treatments viz., C control, T1- compost 1 (Vermi-composted groundnut shell and vegetable waste (25g)) T2- compost 2 (Vermi-composted groundnut shell and vegetable waste (50g), T3-compost 3 (Vermi-composted groundnut shell and vegetable waste (75g). Chlorophyll, protein, and carbohydrate content were analyzed...
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Posted by admin on Feb 28, 2021 in |
The fruits of the plant Ficus racemosa and Ficus auriculata are consumed as a wild edible fruit and have also been used extensively in traditional medicine to treat various illnesses ranging from diarrhea, dysentery, jaundice to diabetes, piles, asthma, and urinary diseases. Gas Chromatography-Mass Spectro-metry (GC-MS) analysis of methanol extract of the fruits was carried out to identify the possible bioactive compounds. The major constituents identified in F. racemosa were 9, 12, 15-octadecatrienoic acid (z,z,z)- (14.323%); (z)6,(z)9-pentadecadien-1-ol (10.190%); Resorcinol (5.613%); n-hexadecanoic acid (2.965%) and Chloroacetic acid, dodec-9-ynyl ester (0.659%). The compounds like 9,12,15-Octadecatrienoic acid, (Z,Z,Z)- (58.216%); L-(+)-Ascorbic acid 2,6-dihexadecanoate (5.459%); Geranylgeraniol (0.432%); 9,12-Octadecadienoyl chloride, (Z,Z)- (0.151%) and 2H- Benzo [f]oxireno [2, 3-E] benzofuran-8 (9H)-one, 9-[[[2-(dimethyl-amino) ethyl]amino]methyl]octahydro-2,5a-dimethyl- (0.132%) were identified in F. auriculata. The Fourier-Transform Infrared Spectroscopy (FT-IR) analysis indicated the presence of N-H, O-H, C=C, C=O, C-H, C-O, S=O, C-N, and N-O functional groups. The results confirm the presence of bioactive components, which are known to exhibit medicinal value as well as pharmacological...
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Posted by admin on Feb 28, 2021 in |
Heparin is a mixture of glycosaminoglycan (GAG) chains originating from the porcine intestinal mucosa. It is used therapeutically as an anticoagulant for the treatment and prevention of thrombosis. Glyco-saminoglycans such as heparin (H) and heparan sulfate (HS) are considered attractive therapeutic agents because they modulate many biological processes and have been implicated in numerous pathologies, including cardiovascular, cancer, inflammation, metabolic, and neurodegenerative diseases and viral infections. These biological functions are believed to be dependent on the interaction of these linear polysaccharides with key proteins such as growth factors, cytokines, proteases, adhesion proteins, lipid binding proteins, etc., which have a heparin-binding domain in common and are termed heparin binding proteins (HBPs). The variability in unfractionated heparin’s pharmacokinetic properties and pharmacological effects led to the development of low MW heparin (LMWH), which is a degraded product of heparin using chemical or enzymatic cleavage techniques. The most common form of LMWH in the U.S. is enoxaparin, which is produced by β-eliminative cleavage of the benzyl esters of porcine mucosal heparin under alkaline...
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Posted by admin on Feb 28, 2021 in |
Today, Nanotechnology is widely used for leading new dosage forms. Vesicular drug delivery system is expanding as one of advanced nanotechnology. Delivery of drugs using colloidal particulate carriers and liquid crystalline compact niosomal hybrid such as niosome and proniosomes has peculiar advantages over conventional dosage forms. Proniosomes is a dry formulation using suitable carrier coated with non-ionic surfactant and can be converted into niosome immediately before use by hydration. These vesicles are amphiphilic molecules having capability of entrapping both hydrophilic and hydrophobic drugs. Vesicular systems are lamellar structures composed of amphiphilic molecules surrounded by an aqueous environment. The non-ionic surfactants are preferred in the proniosomes preparation than cationic, anionic, and ampholytic surfactants because they have the ability to increase solubility which helps in increasing solubility and bioavailability of poorly water soluble drugs. The versatile vesicular drug delivery through the transdermal route is advantageous due to the vesicles tendency to attach and adhere to the cell surface and causes increased permeation rate. However, the major pathways for drug permeation in...
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Posted by admin on Feb 28, 2021 in |
The epidermal growth factor receptor (EGFR), which is a potential anticancer drug target, is over-expressed in non-small-cell lung cancer (NSCLC). The present study is an attempt to explore the human EGFR (protein data bank code: 1M17) inhibition potential of Lipinski compliant compounds possessing 2-arylquinazoli-4-one scaffold with chalcone structural motif; by docking analysis, using Auto Dock 4.0 and Discovery Studio Visualizer. Docking experiments were validated by docking the reported co-crystallized erlotinib confermer at the active site of a target protein. The root means square deviation (RMSD) calculated for the docked co-crystallized confermer by using UCSF chimera was 0.989Ao. Five compounds C21, C42, C47, C10, and C46, were found as the most potent in-silico EGFR inhibitors and their free energy of binding (BE) came in the range of -45.56 kJ/mol to -41.25 kJ/mol. Absorption and toxicity predictions of the compounds were done using ad met SAR, an online prediction tool. The BE of the reference compound afatinib was found to be -32.72 kJ/mol. The understanding of protein-legend interactions would give accurate...
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