Posted by admin on Feb 28, 2021 in |
There are several factors that may induce ulcers in human beings such as stress, chronic use of anti-inflammatory drugs, etc. Though in most cases, the etiology of ulcer is unknown, it has generally accepted that it is the result of an imbalance between aggressive factors and maintenance of the mucosal integrity through the endogenous defense mechanism. Thus, the search for a safe anti-ulcer drug that optimizes these properties is continuing, and part of the search is the evaluation of medicinal plants for gastroprotective properties. The Malvastrum tricuspidatum has used in folk medicine for the treatment of inflammation and gastrointestinal diseases. In this study, we assessed for anti-ulcer activities with aqueous extract and in-vitro method as the acid-neutralizing capacity and H+/K+ – ATPase inhibition activity method and. In acid-neutralizing capacity (ANC), the extract significantly reduced ANC to 9.33 at a concentration of 1500 mg as compared to 15.7 with standard Aluminium hydroxide + Magnesium hydroxide (500mg). While in H+ /K+ – ATPase inhibition activity, the extract showed maximum percentage inhibition...
Read More
Posted by admin on Feb 28, 2021 in |
The important barrier in transdermal drug delivery (TDD) is the Stratum corneum (SC), the outermost layer of the skin, which acts as an excellent protective physiological barrier. To boost the penetration or permeation of drugs through SC, several tactics have been used including passive and active methods of permeation or both in combination. This unwraps the opportunity to broaden the range of drugs that can be administered through the transdermal route, performed as alternatives to existing products, and overcomes the weaknesses of conventional routes. The Nanostructured Lipid Carriers (NLCs) seem to be excellent candidates over conventional drug delivery systems. NLCs are fastly growing and in increased demand from pharmaceutical research groups globally since the last decade. After development of liposomes and Solid Lipid Nanoparticles (SLN), NLCs were introduced. NLC overcomes the limitations of SLN, like the limited drug loading capacity and drug expulsion during storage. NLCs receive a preferred choice of formulation in the cosmeceutical market and Pharmaceutical market as well. This review is an overview of the different permeation...
Read More
Posted by admin on Feb 28, 2021 in |
DNA bar-coding is an ordered strategy that utilizes a little genetic marker in insect DNA to distinguish animal categories, as well as unidentified species. The present investigation manages the utilization of COI gene sequences in the distinguishing proof and documentation of edible insects in Nagaland. More than 2000 types of edible insects are recorded in more than 300 ethnic groups all around the world. It is evaluated that more than 200 types of species of edible insects and other invertebrates are consumed in North East India. In the preliminary study, Vespa affinis was selected and morphologically identified with the help of local tribals in Nagaland. Vespa affinis was identified by using phylogenetic tree analysis, and COI gene sequences were submitted in NCBI to received the accession number (MN820554), BOLD (ACH6486), and COI gene sequence were submitted in BOLD to generated DNA barcode for edible insects of Vespa...
Read More
Posted by admin on Feb 28, 2021 in |
The contamination of Rice and its by-products with storage fungi, especially toxigenic Aspergillus flavus and Aflatoxin B1 leads to potential health hazard to human and domestic animals. Therefore, the present investigation was focussed on the comparative analysis of the fungal contamination with A. flavus and Aflatoxin B1 in Raw and Parboiled paddy and its milling fractions like Husk, Brow Rice, Polished rice and rice bran in a normal rice mill and controlled mill environment. The results of the study indicated that the raw and parboiled paddy showed 100% contamination with fungi in untreated grains in which A. flavus occurred 63% and 77%, respectively. The level of Aflatoxin B1 in untreated Raw and Parboiled paddy was 36 ppb and 50 ppb, respectively. The husk analyzed for the presence of fungal contamination showed 100%, 85%, and the A. flavus was 43%, 30% respectively for Raw and Parboiled grains. But there is no Aflatoxin B1. Found in either of the husk samples. The brown rice exhibited almost closer to the untreated Raw...
Read More
Posted by admin on Feb 28, 2021 in |
Excessive heterogeneity in the phenotypic expression of drug treatment response and adverse drug reaction is resolute by a complex interaction of multiple hereditary variants and environmental aspects. The complex nature of treatment response greatly increases the need for personalized medicine. Drug metabolizing enzymes show monogenic genetic polymorphism and influence drug response. Cytochrome P450 enzymes have clinically relevant variation in their effects. Understanding the genome, proteome, plus metabolic pathways have improved drug development. The application of pharmacogenomics, the use of biomarkers, the molecular system approach, and metabolomics technology will certainly help in the development of personalized medicine. Proteomic technology requires further development for analyzing a massive amount of genes and protein profile data. There is the need to cheer a paradigm shift from traditional medical practices to personalized medicine. Due to the high prevalence of inherited genetic disorders and non-communicable diseases, personalized medicine has its own significance. It aims to enhance awareness, motivation, and sincere efforts towards better and...
Read More
